Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Proteomics And Phosphoproteomics Of Brain: (1) Analyses Of The Pink1 Knockout Model Of Parkinson Disease; (2) Insights Into The Progression Of Alzheimer Disease; And (3) The Naked Mole-Rat Model Of Salubrious Aging, Judy C. Triplett
Theses and Dissertations--Chemistry
Proteomics is the field of science in which proteins produced by an organism (the proteome) are identified. The level of a particular protein can vary with time and the influence of cellular stressors. The study of phosphoproteomics is vital because tyrosine, serine and threonine phosphorylation modulate protein structure and function and is a crucial regulator of cellular signaling pathways. Dysregulation of protein and phosphorylation levels has been reported in multiple neurodegenerative disorders including Parkinson disease (PD) and Alzheimer disease (AD).
PINK1 is a mitochondrial serine/threonine kinase that polices mitochondrial integrity. Mutations in this protein are associated with familial early-onset PD. …