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Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Consumer Perspectives Of Health During Prenatal Care In The Usa And Iceland: An Exploratory Study, Claudia Wiseman
Consumer Perspectives Of Health During Prenatal Care In The Usa And Iceland: An Exploratory Study, Claudia Wiseman
Electronic Theses and Dissertations
Purpose: Prenatal care (PNC) is the healthcare service most often provided to women of childbearing age throughout the world. Poorly understood and defined, based on culture, and expensive for any healthcare system, PNC remains a target for change and improvement. The purpose of this cross-national qualitative research study using narrative inquiry methods was to explore consumer perspectives of individual health and routine PNC in the USA and Iceland. Methods: A purposive sampling technique was used to identify study participants (n = 32) from the United States (n = 16) and Iceland (n = 16). Data were collected via a semi …
Effects Of An Evidence-Based Intervention On Stress And Coping Of Families Of Critically Ill Trauma Patients, Sandra Knapp
Effects Of An Evidence-Based Intervention On Stress And Coping Of Families Of Critically Ill Trauma Patients, Sandra Knapp
Electronic Theses and Dissertations
Problem/Purpose: Critical care nurses are frequently exposed to the stress experienced by their patients' families, yet they often do not have the knowledge or skills to help family members cope with the stress of critical illness. While needs and stressors of families of the critically ill have been researched extensively, no prior studies have been conducted to determine the effects of an evidence-based nursing intervention for reducing family members' stress and improving their coping skills. The purpose of this study was to determine if an evidence-based nursing intervention designed to address the needs of family members would reduce stress and …
Cohort Study Of Pain Behaviors In The Elderly Residing In Skilled Nursing Care, Allison Burfield
Cohort Study Of Pain Behaviors In The Elderly Residing In Skilled Nursing Care, Allison Burfield
Electronic Theses and Dissertations
An integral concern across care settings is the prompt intervention for patients suffering with pain. Long-term care (LTC) settings present with unique challenges to assess and manage pain in resident populations. Pain assessment is especially challenging, because residents have varying degrees of cognition to communicate their pain, and clinician/staff knowledge of pain symptoms may be lacking. The purpose of this research was to improve the measurement of pain and outcomes of care for the elderly residing in skilled nursing care, especially those with cognitive-impairment. The specific aims of this study were to: 1) Determine the magnitude of the relationship between …
Awareness Of Increased Risk For Heart Disease And Cardiovascular Risk Factors In Women With Systemic Lupus Erythematosus, Patricia Weinstein
Awareness Of Increased Risk For Heart Disease And Cardiovascular Risk Factors In Women With Systemic Lupus Erythematosus, Patricia Weinstein
Electronic Theses and Dissertations
Women with systemic lupus erythematosus (SLE) develop cardiovascular disease (CVD) earlier and at a more accelerated rate compared to women without SLE. Many women with SLE are unaware of their increased risk despite years spent in the health care system, thus giving the atherogenic process time to accrue damage. Research has not explained fully why women with SLE are unaware of their increased risk for CVD or why awareness does not correspond to risk-educing behaviors. Stage theories of behavior like the Precaution Adoption Process Model (PAPM) propose that health behavior change proceeds through qualitatively different stages, and people at one …
Cellular And Molecular Mechanisms Of Toxin Resistance For Endoplasmic Reticulum Translocating Toxins, Christopher Massey
Cellular And Molecular Mechanisms Of Toxin Resistance For Endoplasmic Reticulum Translocating Toxins, Christopher Massey
Electronic Theses and Dissertations
The endoplasmic reticulum (ER) is the site of co- and post-translational modification for secretory proteins. In order to prevent vesicular transport and secretion of misfolded or misassembled proteins, a highly regulated mechanism called ER-associated degradation (ERAD) is employed. This pathway recognizes misfolded proteins in the ER lumen and targets them to the cytosol for ubiquitination and subsequent degradation via the 26S proteasome. Sec61 and Derlin-1 are ER pores through which export occurs. AB-type protein toxins such as cholera toxin (CT), Shiga toxin (ST), exotoxin A (ETA), and ricin have evolved means of exploiting the ERAD pathway in order to reach …
A Model Of Treating Hyperfunctional Voice Disorders For School Age Children Within A Serious Gaming Environment, Suzanne King
A Model Of Treating Hyperfunctional Voice Disorders For School Age Children Within A Serious Gaming Environment, Suzanne King
Electronic Theses and Dissertations
The purpose of the present study is to test the feasibility of implementing a video-game based intervention protocol as a means to improve therapy compliance in school age children with hyperfunctional voice disorders. Three levels of modification were made to an existing entertainment software program in order to implement the therapeutic protocol and test compatibility. The third level of modification included a two-phase quasi-experimental single subject design with a school age participant receiving the video game therapy protocol and traditional therapy for equal time. The independent variables for this study included the mode of voice therapy delivery (traditional vs. video …
Microscopic Analysis Of Sympathetic And Parasympathetic Distribution, Terminal Morphology, And Interaction In Whole-Mount Atria, Scott Harden
Electronic Theses and Dissertations
The sympathetic (SNS) and parasympathetic (PSNS) branches of the autonomic nervous system (ANS) innervate the heart, exerting excitatory and inhibitory influences (respectively) over cardiac functions (heart rate, AV conduction velocity, and contractility). However, the distribution and structure of SNS and PSNS innervation has not yet been well studied. Detailed characterization of the distributional organization and structural morphology of the SNS and PSNS in normal states is essential to the study of pathological autonomic remodeling. The present study utilized double immunohistochemical labeling techniques to examine tyrosine hydroxylase (TH) immunoreactive (IR) SNS and vesicular acetylcholine transporter (VAChT) IR PSNS axons and terminal …
Zinc-Finger Protein Mcpip In Cell Death And Differentiation, Craig Younce
Zinc-Finger Protein Mcpip In Cell Death And Differentiation, Craig Younce
Electronic Theses and Dissertations
Monocyte chemotactic protein-1 (MCP-1) plays a critical role in the development of cardiovascular diseases. How MCP-1 contributes to the development of heart disease is not understood. We present evidence that MCP-1 causes death in cardiac myoblasts, H9c2 by inducing oxidative stress, ER stress and autophagy via a novel Znfinger protein, MCP-1 induced protein (MCPIP). MCPIP expression caused cell death and knockdown of MCPIP, attenuated MCP-1 induced cell death. Expression of MCPIP resulted in induction of iNOS and production of reactive oxygen (ROS). It caused induction of NADPH oxidase subunit phox47 and its translocation to the cytoplasmic membrane. Oxidative stress led …
Epigenetic Control Mechanisms In Somatic Cells Mediated By Dna Methyltransferase 1, Bongyong Lee
Epigenetic Control Mechanisms In Somatic Cells Mediated By Dna Methyltransferase 1, Bongyong Lee
Electronic Theses and Dissertations
DNA methylation regulates gene expression through a complex network of protein/protein and protein/DNA interactions in chromatin. The maintenance methylase, DNA methyltransferase 1 (DNMT1), is a prominent enzyme in the process that is linked to DNA replication and drives the heritable nature of epigenetic modifications in somatic cells. The mechanistic details that explain how DNMT1 catalytic action is directed in a chromatin setting are not well understood. We hypothesize that post translational modifications and a variety of protein-protein interactions processes are key regulatory elements that set the methylation of CpG elements essential for normal growth behavior in somatic cells. These fundamental …
Bacterial Selenoproteins: A Role In Pathogenesis And Targets For Antimicrobial Development, Sarah Rosario
Bacterial Selenoproteins: A Role In Pathogenesis And Targets For Antimicrobial Development, Sarah Rosario
Electronic Theses and Dissertations
Selenoproteins are unique proteins in which selenocysteine is inserted into the polypeptide chain by highly specialized translational machinery. They exist within all three kingdoms of life. The functions of these proteins in biology are still being defined. In particular, the importance of selenoproteins in pathogenic microorganisms has received little attention. We first established that a nosocomial pathogen, Clostridium difficile, utilizes a selenoenzyme dependent pathway for energy metabolism. Following this initial characterization, we demonstrate that this pathway is linked to production of toxins by this organism. Finally, we show that interruption of selenium metabolism is a viable pathway for development of …
Categorical Perception Of Stop Consonants In Children With Autism, Laura Bourdeau
Categorical Perception Of Stop Consonants In Children With Autism, Laura Bourdeau
Electronic Theses and Dissertations
The purpose of this study is to determine whether children with autism recognize the same perceptual voicing boundaries of stop consonants as normally developing children of the same age group. This was explored using three groups of participants: ten children with autism between the ages of 8-14, five typically developing children between the ages of 8-14, and five typically developing seven-year-old children. Children in all groups listened to initial stop consonant syllables with voicing contrasts, with voiced and voiceless cognates presented. The initial consonants were altered along a voice onset time continuum within the typically perceived boundaries of each consonant. …