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Full-Text Articles in Medicine and Health Sciences
Pain Among Older Adults With Cancer-Results From The Cancer And Aging Resilience Evaluation (Care) Registry, Mustafa Al Obaidi
Pain Among Older Adults With Cancer-Results From The Cancer And Aging Resilience Evaluation (Care) Registry, Mustafa Al Obaidi
All ETDs from UAB
Purpose: The impact of pain on functional status and mental health among older adults with cancer is a relevant, yet understudied issue. Our aim of this study sought to identify prevalence of pain at diagnosis in older adults with cancer and evaluate the association with functional status limitations, cognition, and mental health issues. Methods: This study included patients diagnosed with cancer at age ≥60 enrolled in the CARE Registry at University of Alabama at Birmingham. Patients completed a patient-reported geriatric assessment at the time of their initial visit with a medical oncologist. Pain measured in numeric rating scale from 0-10. …
Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson
Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson
All ETDs from UAB
Cancer is a complex disease characterized by uncontrolled growth of transformed cells that can arise in many tissue types throughout the body (e.g., breast, lung, prostate, pancreas, lymph nodes) and is a major cause of death worldwide. Cancer progression resulting in aggressive or metastatic disease accounts for one of the leading causes of death worldwide, second only to heart disease in the US. Incidentally, cancer-related mortality has been on a steady decline, dropping 25% over the last 25 years [1]. This could be attributed to improved and earlier diagnoses and better treatment options being developed over the past few decades. …
Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie
Characterization Of Rna Polymerase I Trigger Loop Mutations, Collin Ainslie
All ETDs from UAB
RNA polymerases are primarily multi-subunit enzymes that synthesize RNAs from template DNA strands. RNA polymerase I (Pol I) is the eukaryotic RNA polymerase that synthesizes the majority of ribosomal RNA (rRNA) for ribosome production. These include the 5.8S, 28S, and 18S rRNAs which are synthesized from a polycistronic gene in the nucleolus. The rRNAs synthesized by Pol I, the 5S rRNA, & ribosomal proteins come together to synthesize ribosomes through ribosome biogenesis. Dysregulation of Pol I activity has been established to contribute to dysregulation of ribosome biogenesis and disease state development. These conditions include but are not limited to Cincinnati …