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Full-Text Articles in Medicine and Health Sciences
Risk Assessment And Staging Of Cardiometabolic Diseases, Fangjian Guo
Risk Assessment And Staging Of Cardiometabolic Diseases, Fangjian Guo
All ETDs from UAB
Obesity is associated with elevated risk for morbidity and mortality and has become an epidemic both in the United States and around the world. Insulin resistance is essentially involved in the pathogenic process of cardiometabolic diseases in obese people, which involves defects in glucose production by the liver and insulin-stimulated glucose uptake and utilization by peripheral tissues. Insulin resistance appears at an early stage of life and is the first step in the development of cardiometabolic diseases. Long-term insulin resistance will induce metabolic syndrome and prediabetes and eventually will cause type 2 diabetes and cardiovascular diseases. Obesity may exacerbate insulin …
Gut Microbiome And Its Role In Obesity And Aging In C57bl/6j Mice, Yongbin Yang
Gut Microbiome And Its Role In Obesity And Aging In C57bl/6j Mice, Yongbin Yang
All ETDs from UAB
The gut microbiome has been found to be associated with obesity, type 2 diabetes and many other diseases. Many studies have shown microbial composition changes with obese status or switching of diets. However, few of them have investigated the long-term microbial changes in subjects under the same environmental factors. This study examined gut microbiome changes in multiple aspects with well-controlled diet-induced obese mice models and demonstrated the following: there were great variations in gut microbiome composition and diversity in the same strain of inbred mice under the same environment and diet; certain lineages of bacteria were associated with digestive efficiency; …
Mitochondrial Genetics Modify Body Composition, Metabolic Efficiency And Myocardial Metabolism, Kimberly Joanne Dunham
Mitochondrial Genetics Modify Body Composition, Metabolic Efficiency And Myocardial Metabolism, Kimberly Joanne Dunham
All ETDs from UAB
Obesity and cardiometabolic pathologies have reached epidemic levels worldwide over the last 30 years. Currently, the majority of research investigating possible genetic causes of obesity is focused on nuclear DNA (nDNA). While this has lead to the development of numerous animal models, it is apparent the etiology of obesity is more complex than single gene mutations. Recently it has also been suggested that mitochondrial DNA (mtDNA) mutations sustained during evolution as a consequence of our prehistoric environment may influence individual propensity and risk of disease. Contemporary human populations are no longer faced with the challenges of our ancestors such as …