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Articles 1 - 30 of 577
Full-Text Articles in Medicine and Health Sciences
Mutant Tdp-43 In Motor Neurons Promotes The Onset And Progression Of Als In Rats, Cao Huang, Jianbin Tong, Fangfang Bi, Hongxia Zhou, Xu-Gang Xia
Mutant Tdp-43 In Motor Neurons Promotes The Onset And Progression Of Als In Rats, Cao Huang, Jianbin Tong, Fangfang Bi, Hongxia Zhou, Xu-Gang Xia
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration, which ultimately leads to paralysis and death. Mutation of TAR DNA binding protein 43 (TDP-43) has been linked to the development of an inherited form of ALS. Existing TDP-43 transgenic animals develop a limited loss of motor neurons and therefore do not faithfully reproduce the core phenotype of ALS. Here, we report the creation of multiple lines of transgenic rats in which expression of ALS-associated mutant human TDP-43 is restricted to either motor neurons or other types of neurons and skeletal muscle and can be switched on and off. …
Treatment Of Chronic Mental Illness, Anu A. Matorin, Md
Treatment Of Chronic Mental Illness, Anu A. Matorin, Md
Jefferson Journal of Psychiatry
RESIDENT'S GUIDE TO TREATMENT OF PEOPLE WITH CHRONIC MENTAL ILLNESS
(GAP Report 136; 1993)
Formulated by the Committee on Psychiatry and the Community, Group for the Advancement of Psychiatry American Psychiatric Press, Inc., 1993, 230 pages, $30.00
A Mesmerizing Book, Daniel A. Monti, Md
A Mesmerizing Book, Daniel A. Monti, Md
Jefferson Journal of Psychiatry
HYPNOSIS IN THE RELIEF OF PAIN
Ernest R. Hilgard and Josephine R. Hilgard
Brunner/Maze!, Inc., New York 1994, paperback, $28 .95, 294 pgs.
Prediction Of Treatment Response And Diagnosis In Psychiatry, Eduardo Dunayevich, Md
Prediction Of Treatment Response And Diagnosis In Psychiatry, Eduardo Dunayevich, Md
Jefferson Journal of Psychiatry
The lack of diagnostic gold standards and the multiplicity of vantage points used to conceptualize mental illness renders psychiatric diagnostic and therapeutic approaches susceptible to individual and cultural biases. Developments in therapeutic approaches have often provided vantage points from which to conceptualize psychopathology. The identification of predictors of treatment response may be a useful element for clinicians to select between multiple treatment tools in an expanding therapeutic armamentarium while fostering refinements in current diagnostic systems.
The Forgotten Evaluation: Taking Competence Seriously, Seth E. Tabb, Md, Scott A. West, Md
The Forgotten Evaluation: Taking Competence Seriously, Seth E. Tabb, Md, Scott A. West, Md
Jefferson Journal of Psychiatry
The medical literature devotes little attention to the application of competency to the general medical patient. Commonly, the only cases recognized as necessitating a competency evaluation are overtly psychotic patients, patients requiring written informed consent, and those patients who refuse treatments strongly recommended by their physician. Clarifying terminology and redefining competency provides a practical screening method for assessing competency in all patients. When physicians neglect the evaluation of competency, patient autonomy is compromised. Not only are all physicians capable of performing a competency evaluation, they are ethically and professionally required to do so.
Transition To Psychiatric Residency: Unique Stresses; Unique Rewards, Catherine A. Belitsky, Md, Frcp(C), Sidney H. Kennedy, Md, Frcp(C)
Transition To Psychiatric Residency: Unique Stresses; Unique Rewards, Catherine A. Belitsky, Md, Frcp(C), Sidney H. Kennedy, Md, Frcp(C)
Jefferson Journal of Psychiatry
An individual's decision to pursue a psychiatric residency following medical school training is shaped by many factors. Beginning residents are often ill prepared for the relative impact that the shift from medical doctor to psychiatric resident entails. This paper reviews the literature regarding demographic and psychological factors relating to recruitment, dynamic and practical issues confronting the beginning resident, and various coping styles adopted. These factors are considered in the context of an inpatient setting where the majority of residents begin their training. Much of the resident response is seen as adaptive and a number of strategies for coping are suggested.
Patients Who Request A Female Psychotherapist, Timothy C. Smith, Md, Melinda Fudge, Md, Salman Akhtar, Md, Steven Samuel, Phd
Patients Who Request A Female Psychotherapist, Timothy C. Smith, Md, Melinda Fudge, Md, Salman Akhtar, Md, Steven Samuel, Phd
Jefferson Journal of Psychiatry
Upon arriving at an outpatient clinic, many patients request to see a female psychotherapist. Yet little has been written on this topic. The aim of this study was to explore the demographic and clinical characteristics of such patients. We compared patients who voiced a preference for a female therapist with controls on the demographic variables of age, sex, race, marital and financial status and the clinical characteristics of diagnosis, history of sexual abuse, sexual preference, overt presence of sexual or social difficulties, history of prior treatment, gender of the previous therapist, and treatment drop out rate. A chi square analysis …
Non-Neuroleptic Pharmacotherapy Of Schizophrenia, Sajiv John, Md, Atul Mahableshwarkar, Md
Non-Neuroleptic Pharmacotherapy Of Schizophrenia, Sajiv John, Md, Atul Mahableshwarkar, Md
Jefferson Journal of Psychiatry
Patients with schizophrenia are typically treated with a neuroleptic and some form of psychosocial intervention. In spite of optimum treatment, up to one-third of patients continue to remain severely disabled due to persistent positive or negative symptoms. A variety of drugs have been tried as alternatives or additions to traditional neuroleptics in these patients. This paper is a review of these nonneuroleptic treatment alternatives and an attempt to establish some guidelines for their use.
A Case Study Of Obsessive-Compulsive Disorder: Some Diagnostic Considerations, Jeanette M. Stumbo Zaimes, Md
A Case Study Of Obsessive-Compulsive Disorder: Some Diagnostic Considerations, Jeanette M. Stumbo Zaimes, Md
Jefferson Journal of Psychiatry
Obsessive-Compulsive Disorder (OCD) was considered a rare disorder prior to 1984 when the initial results from the Epidemiologic Catchment Area survey demonstrated a substantial prevalence of the disorder (1). Thus there may be many patients today who entered treatment prior to 1984 with undiagnosed OCD. This paper gives the history of one such patient and reviews the current literature on OCD as it pertains to the diagnostic evidence in this case.
Concepts And Models Of Empathy: Past, Present, And Future, Elizabeth Ann Baxter, Md
Concepts And Models Of Empathy: Past, Present, And Future, Elizabeth Ann Baxter, Md
Jefferson Journal of Psychiatry
The subject of empathy has been increasing in popularity and importance; correspondingly, the theoretical aspects of empathy are in need of further development. This paper outlines key concepts and processes related to empathy, particularly the mechanisms of identification and regression as they are discussed in the models of empathy articulated by Fleiss, Greenson, and Jordan. Similarities and differences of the models are examined, in addition to each model's description of the roles of identification and regression. Although each model has made significant contributions towards a theoretical perspective of empathy, none of them have distinguished pathological from non-pathological uses of identification. …
Case Report: Sometimes A Cigar Is Just A Cigar, Zafar Y. Ibrahim, Md, Ellen F. Brooks, Md
Case Report: Sometimes A Cigar Is Just A Cigar, Zafar Y. Ibrahim, Md, Ellen F. Brooks, Md
Jefferson Journal of Psychiatry
This unusual case underscores the need for psychiatrists to consider treatable and curable causes of acute behavior changes even when historical data are not easily available. This case presentation invites physicians of mind (and body) to utilize simple and common-sense approaches while evaluating their patients.
Editor's Column, Mary E. Donovan, Md
Editor's Column, Mary E. Donovan, Md
Jefferson Journal of Psychiatry
"Sometimes a cigar is just a cigar. " Others had learned, "My son, sometimes a cigar is just a good smoke." Like many of our colleagues, we believed that these were Freud's words during a question and answer session after a lecture he gave at Clark University. The words were comforting in a way, giving us a chance to chalk at least some things up to pure coincidence, thus releasing us from relentless unconscious agendas and hidden sexual interpretations.
Editorial Staff
Jefferson Journal of Psychiatry
Editorial staff for Volume 12, Number 2, 1995 Jefferson Journal of Psychiatry.
Current Concepts-Past Contributions, Cynthia L. Theiss, Md
Current Concepts-Past Contributions, Cynthia L. Theiss, Md
Jefferson Journal of Psychiatry
WOMEN BEYOND FREUD: NEW CONCEPTS OF FEMININE PSYCHOLOGY
Edited by Milton M. Berger, M.D., with chapters by Marianne Horney Eckardt, Carol Gilligan , Douglas H. Ingram, Helen Singer Kaplan, Harold I. Lief, Jean Baker Miller, Silvia W. Olarte, Susan Quinn, and Mario Rendon
Brunner/Mazel, Inc., New York , 1994, 162 pages, $26.95
Old Age No Barrier To Psychotherapy, Jeanette Oleskowicz, Md
Old Age No Barrier To Psychotherapy, Jeanette Oleskowicz, Md
Jefferson Journal of Psychiatry
THE PSYCHOTHERAPY OF THE ELDERLY SELF
Hyman Muslin MD
Brunner /Mazel Inc., New York 1992, Hard cover
$27.50, 220 pages
Life Under Scrutiny, Andres Martin, Md
Life Under Scrutiny, Andres Martin, Md
Jefferson Journal of Psychiatry
ON KISSING, TICKLING, AND BEING BORED: PSYCHOANALYTIC ESSAYS ON THE UNEXAMINED LIFE
Adam Phillips
Harvard University Press Cambridge, Massachusettes
1993, Hardcover, 138 pages, $ 19.95
Sexual Side Effects Of Psychiatric Medications In Women: A Clinical Review, Laura L. Post, Md, Faacs
Sexual Side Effects Of Psychiatric Medications In Women: A Clinical Review, Laura L. Post, Md, Faacs
Jefferson Journal of Psychiatry
Sexual side effects of psychiatric medications have been estimated to occur in 60% of male clients (1) and 30% of female clients (2). Despite a body of literature relating individual medications to specific sexual side effects, few studies have satisfactorily addressed the psychotropic-induced sexual dysfunctions in women. The spectrum of known sexual sided effects resulting from psychopharmacologic interventionswill be reviewed. Guidelines for appropriately addressing the possibility of sexual side effects within a therapeutic relationship for maximizing reporting of sexual side effects, and for possible treatment approaches to sexual side effects will be described.
Positron Emission Tomography In Psychiatry: New Sights, New Insights, Shitij Kapur, Md, Sylvain Houle, Md, Phd, Frcp (C), Gregory M. Brown, Md, Phd, Frcp (C)
Positron Emission Tomography In Psychiatry: New Sights, New Insights, Shitij Kapur, Md, Sylvain Houle, Md, Phd, Frcp (C), Gregory M. Brown, Md, Phd, Frcp (C)
Jefferson Journal of Psychiatry
Positron Emission Tomography (PET) is a new tool with which to explore the neurobiological basis of psychiatric illness. PET permits in-vivo measurement of regional cerebral blood flow, regional glucose metabolism, as well as information about neurochemicals and their receptors. Since regional cerebral bloodflow and glucose metabolism reflect ongoing neuronal activity, the neural bases of different cognitive processes and emotional states can be discerned using PET. Findings from recent studies in schizophrenia, affective disorders, obsessive-compulsive disorders, anxiety disorders, and dementia are reviewed with a special emphasis on how these findings may' be useful in developing a more comprehensive framework for understanding …
Literature Review: Stress Reactance In Psoriatic Patients, W. Michael Hooten, Md
Literature Review: Stress Reactance In Psoriatic Patients, W. Michael Hooten, Md
Jefferson Journal of Psychiatry
The association between stress and psoriasis is well documented. A subgroup of psoriatic patients appear to be high stress reactors who can identify specific psychosocial stresses which exacerbate their psoriasis. In contrast, low stress reactors report no association between stress and the exacerbation of psoriasis. In differentiating high versus low stress reactors, a review of the literature suggests: 1) a neurogenic mediated disease process; 2) high stress reactors' disease course is not confounded by underlying psychopathology and, 3) high stress psoriatics experience more disease related stress than low stress reactors.
Being Stalked: A Psychiatrist's Perspective, Kalpana I. Nathan, Md, Tina T. Lee, Md, James Missett, Md, Phd
Being Stalked: A Psychiatrist's Perspective, Kalpana I. Nathan, Md, Tina T. Lee, Md, James Missett, Md, Phd
Jefferson Journal of Psychiatry
It is only recently that stalking has been criminalized after some highly publicized forensic cases. Psychiatric focus has been on erotomania, and in this article we primarily highlight stalking as a separate entity with psychiatric and legal implications. The case reports reveal our vulnerability as therapists, and we hope will raise our awareness of stalking as a potentially dangerous situation. The legal statutes vary in different states, but our recommendations may provide guidelines towards formulating policies and procedures for the safety of healthcare providers.
The Diagnosis Of Multiple Personality Disorder, Joshua D. Mcdavid, Md, Mph
The Diagnosis Of Multiple Personality Disorder, Joshua D. Mcdavid, Md, Mph
Jefferson Journal of Psychiatry
This paper represents an attempt to facilitate the clinician or psychiatrist in making a diagnosis of Multiple Personality Disorder, the most severe of the dissociative disorders. Emphasis will be placed on detecting signs, symptoms, and information that occur within the constituent parts of a typical psychiatric interview, and that are highly suggestive of MPD even in the absence of alter presentation.
Theme And Content Of Delusions In Asian Indian Psychotic Patients: Correlation With Diagnosis, Christopher Linskey, Md
Theme And Content Of Delusions In Asian Indian Psychotic Patients: Correlation With Diagnosis, Christopher Linskey, Md
Jefferson Journal of Psychiatry
The aim of this study was to investigate the types of delusions present in Asian Indian psychotic patients and evaluate correlation with patient diagnosis. Delusional narratives were collected from 50 Indian patients with schizophrenia or an affective disorder. These narratives were judged for delusional theme and content and were correlated with DSM-III-R diagnoses. Using simple categorical analysis, delusional themes of grandiosity and guilt correlated with affective diagnoses. Delusional themes of reference and Schneiderian types were more often associated with schizophrenia. These findings support the concept that delusional themes can be used as valid diagnostic clues in the assessment of psychotic …
Integration Of Assertive Community Treatment Into A Residency Curriculum: The Resident's Perspective, D. Walter Hiott, Md, Alberto B. Santos, Md
Integration Of Assertive Community Treatment Into A Residency Curriculum: The Resident's Perspective, D. Walter Hiott, Md, Alberto B. Santos, Md
Jefferson Journal of Psychiatry
Assertive Community Treatment (ACT) is a service delivery system designed to provide long-term quality care to patients with chronic mental illnesses. A brief description of these programs is presented. These programs can provide valuable training experiences for psychiatric residents. The authors report the results of their survey of residents whose training included a rotation through these services.
The Serotonin Theory Of Depression, Christopher W. Kerr
The Serotonin Theory Of Depression, Christopher W. Kerr
Jefferson Journal of Psychiatry
In its simplest form, the serotonin deficiency theory of depression postulates that there is a net reduction in serotonin transmission in depressive illness. The pathophysiological change may result from two different mechanisms. The first involves a decrease in serotonin (5-HT) availability which has the consequential effect of compensatory receptor up-regulation or super sensitivity. The second mechanism implies a primary defect in receptor activity and/or signal transduction. The objective of this review is to analyze the serotonin system in depression as it relates to the above two postulates.
Jefferson Journal Award
Jefferson Journal of Psychiatry
The Jefferson Journal Award has been established to honor the best paper submitted during each calendar year to the Jefferson Journal of Psychiatry: A Resident Publication. An award of one thousand dollars is given to the chosen author, with an additional one thousand dollars to be given to the residency program or fellowship in which the author is enrolled. The winning submission is selected by the Journal's editorial board from manuscripts submitted on any subject related to psychiatric practice or research.
The editorial board of the Journal is proud to announce the recipient of the 1993 Jefferson Journal Award: Scott …
Editor's Column, Mary E. Donovan, Md
Editor's Column, Mary E. Donovan, Md
Jefferson Journal of Psychiatry
With this edition of the Jefferson Journal of Psychiatry I am pleased to welcome Edward Silberman, M.D. as our new Faculty Advisor. Dr. Silberman is the Residency Program Director at Thomas Jefferson University, and he brings a great deal of enthusiasm about resident research, writing and publishing to the Journal. In addition to enthusiasm, he brings his own experience with writing for psychiatric publication with which to advise us, and we welcome his guidance as the Journal begins its twelfth year of publication.
Editorial Staff
Jefferson Journal of Psychiatry
Editorial Staff for Volume 12, Number 1, 1994 for Jefferson Journal of Psychiatry.
Psychodynamic Contours Of Post-Traumatic Stress Disorder, Noah D. Freedman, Md
Psychodynamic Contours Of Post-Traumatic Stress Disorder, Noah D. Freedman, Md
Jefferson Journal of Psychiatry
PSYCHOTHERAPY OF THE COMBAT VETERAN
Harvey J. Schwartz, M.D., Ed.New York, Spectrum Publications, 1984
Distributed by: Integrated Publishers, 195 McGregor St., Manchester , NH 03102, 603-669-5933
Psychodynamics: The State Of The Art, Robert Hall, M.D.
Psychodynamics: The State Of The Art, Robert Hall, M.D.
Jefferson Journal of Psychiatry
PSYCHODYNAMIC CONCEPTS IN GENERAL PSYCHIATRY
Harvey J. Schwartz, MD with Efrain Bleiberg, MD and Sidney Weissman, MD editors
American Psychiatric Press, Inc., in press.