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Full-Text Articles in Medicine and Health Sciences
Implications Of Lifecourse Epidemiology For Research On Determinants Of Adult Disease, Sze Yan Liu, R N. Jones, M Maria Glymour
Implications Of Lifecourse Epidemiology For Research On Determinants Of Adult Disease, Sze Yan Liu, R N. Jones, M Maria Glymour
Sze Yan Liu
Many diseases commonly associated with aging are now thought to have social and physiologic antecedents in early life. Understanding how the timing of exposure to early life risk factors influences later-life health may illuminate mechanisms driving adult health inequalities and identify possible points for effective interventions. Recognizing chronic diseases as developing across the lifecourse also has implications for the conduct of research on adult risk factors for disease. We review alternative conceptual models that describe how the timing of risk factor exposure relates to the development of disease. We propose some expansions of lifecourse models to improve their relevance for …
Elders, Values, And Peppermint Candies, Sarah A. Klein, Andrea C. Bostrom
Elders, Values, And Peppermint Candies, Sarah A. Klein, Andrea C. Bostrom
Andrea Bostrom, PhD, PMHCNS-BC
The demographics of the population of the United States are inexorably changing: The baby boomers, who have defined much of the culture of the past half century, will continue to do so over the next 50 years. Just as the population is aging, so are the members of the nursing profession. Working with elders as our patients and as our peers is a reasonable expectation. Encouraging younger nurses to embrace working with elders is a challenge. Learning about how we have come to value aging and our elders is one way to engage the change in the work that nurses …
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
Nader G. Abraham
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. The western diet accelerated functional and morphological evidence for aging whereas pNaKtide attenuated these changes. Next, human dermal fibroblasts (HDFs) were exposed to different types of oxidant stress in vitro each of which increased expression of senescence markers, cell-injury, and apoptosis as well as stimulated the NKAL. Further stimulation of the NKAL with ouabain augmented cellular senescence whereas treatment with pNaKtide attenuated it. …
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
Jiang Liu
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. The western diet accelerated functional and morphological evidence for aging whereas pNaKtide attenuated these changes. Next, human dermal fibroblasts (HDFs) were exposed to different types of oxidant stress in vitro each of which increased expression of senescence markers, cell-injury, and apoptosis as well as stimulated the NKAL. Further stimulation of the NKAL with ouabain augmented cellular senescence whereas treatment with pNaKtide attenuated it. …
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
The Na/K-Atpase Oxidant Amplification Loop Regulates Aging, Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, Jiang Liu, Nader G. Abraham, Joseph I. Shapiro
Komal Sodhi
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. The western diet accelerated functional and morphological evidence for aging whereas pNaKtide attenuated these changes. Next, human dermal fibroblasts (HDFs) were exposed to different types of oxidant stress in vitro each of which increased expression of senescence markers, cell-injury, and apoptosis as well as stimulated the NKAL. Further stimulation of the NKAL with ouabain augmented cellular senescence whereas treatment with pNaKtide attenuated it. …