Medicine and Health Sciences Commons^™

3,4-Methylenedioxymethamphetamine Alters Left Ventricular Function And Activates Nuclear Factor-Kappa B (Nf-Kappab) In A Time And Dose Dependent Manner, David A. Tiangco, Sapna Halcomb, Frank A. Lattanzio Jr, Barbara Y. Hargrave

Bioelectrics Publications

3,4-Methylenedioxymethamphetamine (MDMA) is an illicit psychoactive drug with cardiovascular effects that have not been fully described. In the current study, we observed the effects of acute MDMA on rabbit left ventricular function. We also observed the effects of MDMA on nuclear factor-kappa B (NF-kappa B) activity in cultured rat ventricular myocytes (H9c2). In the rabbit, MDMA (2 mg/kg) alone caused a significant increase in heart rate and a significant decrease in the duration of the cardiac cycle. Inhibition of nitric oxide synthase (NOS) by pretreatment with L-NAME (10 mg/kg) alone caused significant dysfunction in heart rate, systolic pressure, diastolic pressure, …

Dispersion Of Cytotoxic Properties Of Multi-Walled Carbon Nanotubes Suspended In Biological Solutions With Tween 80: Their Role In Enhancing Killing Effects Of Nanosecond Pulse Electric Fields On Tumor Cell Lines, Bhargava S. Kalluri

Biological Sciences Theses & Dissertations

The objective of this study was to determine whether multi-walled carbon nanotubes (MWCNTs) suspended in the surfactant Tween 80 give an additive killing effect on tumor cells when exposed to nsPEFs. In this study, MWCNTs were suspended in DMEM and RPMI with or without T80 (surfactant). The size distribution of MWCNTs suspended in these solutions was evaluated with a Delsa™ Nano Zeta potential and sub micro particle Size Analyzer and confirmed with microscopy. The cytotoxicity of MWCNTs dispersed in different concentrations of T80 was evaluated in PANC1 (Human pancreatic cancer cell line) and Jurkat cell lines (Human T-cell lymphoblast cell …

Distinct Macrophage Subpopulations Regulate Viral Encephalitis But Not Viral Clearance In The Cns, Christina D. Steel, Woong-Ki Kim, Larry Sanford, Laurie Wellman, Sandra Burnett, Nico Van Rooijen, Rochard P. Ciavarra

Biological Sciences Faculty Publications

Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS. …

Persistence Of Community College Transfer Students In A Private Liberal Arts University Nursing Program, Rita M. Amerio

Educational Leadership & Workforce Development Theses & Dissertations

The United States is bracing for the largest shortage of registered nurses that the United States health care system has ever experienced. As the population of "baby boomers," those born between 1946 and 1960, turns 65 beginning in 2011, the nation will be faced with providing health care services to the largest group of elderly Americans in history. Unlike previous generations, this group has had the advantage of advanced medical care that will allow them to live well into their 80s and even 90s.

The purpose of this study was to conduct a preliminary investigation to identify predictor variables that …

Women's Compliance In Outpatient Substance Abuse Treatment: The Role Of Children And Mental Health, Cathy Gertrude Cooke

Psychology Theses & Dissertations

The purpose of this study was to examine the role of children and mental illness in women's compliance in a treatment program for substance abuse. Information was retrieved from medical records of female clients ( N=221) who took part in a community-based day treatment program for substance abuse in a large city in southeastern Virginia during a 32-month period. It was anticipated that, as compared to women who resided with minor children, women who did not reside with minor children would have greater treatment success defined as: (1) more days in the treatment program; (2) higher percentage of negative …

Section Abstracts: Medical Science

Virginia Journal of Science

Abstracts of the Medical Sciences Section for the 88th Annual Meeting of the Virginia Academy of Science, May 20-21, 2010, James Madison University, Harrisonburg, Virginia.

A Gis Analysis Of The Environmental Variables Related To Rift Valley Fever Outbreaks, Jacqueline Florette Jackson

Health Services Research Dissertations

Rift Valley fever is a mosquito-borne disease that causes widespread febrile illness and mortality in domestic animals as well as humans (Gaff, 2007). Rift Valley fever virus was first isolated in 1931 (Daubney, 1931), and since then, outbreaks have occurred in sub-Saharan Africa, southern Africa, Egypt, Saudi Arabia, Yemen and Madagascar, proving it to be a virus able to invade ecologically diverse regions (Gaff, 2007). The potential introduction of Rift Valley fever into the United States suggests the potential for human infection and major economic disruption. It is important to understand the role environmental variables have played in historical outbreaks …

Neuromechanical Analysis Of Anterior Cruciate Ligament Risk Factors In Female Collegiate Soccer Athletes, Nelson Cortes

Human Movement Sciences & Special Education Theses & Dissertations

The anterior cruciate ligament (ACL) acts in an essential role to prevent anterior tibial displacement when experiencing jump-landing forces that are applied to the lower extremity; more than 100,000 injuries per year in the United States in sport activities that often require landing, deceleration-acceleration, cutting and pivoting actions have been reported. The aim of this study was to examine the nature of any lower limb coupling differences between a drop-jump and a side-step cutting actions, assess kinematic and kinetic differences between three tasks, and evaluate the effects of two landing techniques in biomechanical risk factors while performing two unanticipated tasks. …

The Effects Of An Anterior Cruciate Ligament Prevention Program And Retention Period On Lower Extremity Biomechanics, Ryan S. Mccann

Human Movement Sciences & Special Education Theses & Dissertations

Researchers have attempted to determine the effects of strength, flexibility, agility, and plyometric training, as well as expert feedback on biomechanical risk factors for anterior cruciate ligament (ACL) injuries. Currently, the literature lacks information regarding athletes' ability to retain adaptations made during programs designed to reduce biomechanical risk factors for ACL injuries. The purpose of this study was to determine the effects of a 10-week strength and agility program on lower extremity kinetics and kinematics of collegiate athletes immediately following training and after a 11-week retention period. Ten NCAA Division I female soccer players free of lower extremity injury, volunteered …

The Correlation Between Visual Observations And Inclinometric Measurements For Special Tests Related To Patellofemoral Pain Syndrome, Erin Quada

Human Movement Sciences & Special Education Theses & Dissertations

Patellofemoral pain syndrome (PFPS) is generally described as an insidious onset with pain increasing during running, jumping, ascending and descending stairs as well as sitting with the knees flexed for an extended period of time. Clinicians often use special tests in injury evaluations and range of motion assessments, usually making a visual observation of that status of the patient. The purpose of this study was to examine how interval measurements utilized in flexibility and range of motion assessments correlate with visual observations of special tests (active knee extension test, Thomas test, Ober's test, rectus femoris flexibility, and Craig's test). The …

The Effectiveness Of Counselors As Care Managers In Improving Self-Management And Medical Outcomes In Persons With Poorly Controlled Diabetes, Ularisi Rebecca Green

Counseling & Human Services Theses & Dissertations

This study investigated whether providing counselors as care managers to individuals who were having difficulty managing their Type II diabetes improved their self-management, health, and functioning. Counselors used the Motivational Interviewing Model and met weekly over a six month period with patients who had Type II diabetes who had been identified as not functioning well in managing their disease. The success of the intervention was determined by a number of measures including physical symptoms of patients; patients' perceptions of the care they received; and patients' self-efficacy in managing their diabetes. The results of this study suggested that providing counselors as …

The Effects Of Cocaine And Ecstasy On Cardiac Myocytes And The Intact Myocardium, David A. Tiangco

Theses and Dissertations in Biomedical Sciences

Cocaine and ecstasy are widely used illicit drugs. Both drugs have undergone intense scrutiny as information regarding their side-effects has become available. One important yet incomplete area of investigation pertains to their effects on the heart. The purpose of the current studies was to test the hypothesis that exposure to cocaine or ecstasy will adversely affect cellular homeostasis and normal heart function. Cultured cardiac myocytes (H9c2) and New Zealand White rabbits (Oryctolagus cuniculus) were used to measure the responses to various concentrations of cocaine or ecstasy at both the cellular and intact organ system levels. We observed that cocaine and …

Patient Centered Care Approach To Adherence With Cardiovascular Medications: Self-Determination Theory Integration, David S. Li

Health Services Research Dissertations

Problem statement. Behavioral intervention is used to improve adherence with medication in patients with cardiovascular diseases (CVD), but the effect was not sustainable. Patient-centered care (PCC) as a consumer movement has gained acceptance, but it lacks a theoretical framework. Self-determination theory (SDT) may provide an alternative to improve patients' adherence to chronic cardiovascular medication, as well as a theoretical framework for PCC. Both approaches to CVD management have not been evaluated.

Methods. The study was a quasi-experimental pretest posttest comparison design with consecutive sampling of a hospitalized cardiac patient population. Sixty patients each for the usual care (UC) …

Apoptosis Initiation And Angiogenesis Inhibition: Melanoma Targets For Nanosecond Pulsed Electric Fields, Xinhua Chen, Juergen F. Kolb, R. James Swanson, Karl H. Schoenbach, Stephen J. Beebe

Bioelectrics Publications

Many effective anti-cancer strategies target apoptosis and angiogenesis mechanisms. Applications of non-ionizing, nanosecond pulsed electric fields (nsPEFs) induce apoptosis in vitro and eliminate cancer in vivo; however in vivo mechanisms require closer analysis. These studies investigate nsPEF-induced apoptosis and anti-angiogenesis examined by fluorescent microscopy, immunoblots, and morphology. Six hours after treatment with one hundred 300 ns pulses at 40 kV/cm, cells transiently expressed active caspases indicating that caspase-mediated mechanisms. Three hours after treatment transient peaks in Histone 2AX phosphorylation coincided with terminal deoxynucleotidyl transferase dUTP nick end labeling positive cells and pyknotic nuclei, suggesting caspase-independent mechanisms on nuclei/DNA. Large …

Climate Change And Sea Level Rise Initiative (Ccslri), Larry P. Atkinson

CCSLRI Brochures

Brochure of the Old Dominion University Climate Change and Sea Level Rise Initiative (CCSLRI)

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …

Effects Of Training On Physical Performance Wearing Personal Protective Equipment, David P. Swain, James A. Onate, Stacie I. Ringleb, Dayanand N. Naik, Marlene Demaio

Human Movement Sciences & Special Education Faculty Publications

We evaluated the effects of wearing a weighted vest during 6 weeks of military-style training. Forty-three subjects were randomly assigned to a control group or a vest group (carrying 4-5 kg for 2 weeks, and 8-10 kg for 4 weeks), with 37 completing the study (17 vest, 20 control). Both groups performed stair climbing in addition to standard Marine Corps training for 1 hour, four times per week. Pre- and post-tests were performed while wearing military personal protective equipment, with the exception of the Marine Physical Readiness Test (PRT). Both groups significantly improved PRT scores (8.4% 3-mile run, 28-38% calisthenics) …

Plasmid Injection And Application Of Electric Pulses Alter Endogenous Mrna And Protein Expression In B16.F10 Mouse Melanomas, L. C. Heller, Y. L. Cruz, B. Ferraro, H. Yang, R. Heller

Bioelectrics Publications

The application of electric pulses to tissues causes cell membrane destabilization, allowing exogenous molecules to enter the cells. This delivery technique can be used for plasmid gene therapy. Reporter gene expression after plasmid delivery with eight representative published protocols was compared in B16.F10 mouse melanoma tumors. This expression varied significantly based on the pulse parameters utilized for delivery. To observe the possible influence of plasmid injection and/or pulse application on endogenous gene expression, levels of stress-related mRNAs 4 and 24 h after delivery were determined by PCR array. Increases in mRNA levels for several inflammatory chemokines and cytokines were observed …

The Reliability Of Portable Fixed Dynamometry During Hip And Knee Strength Assessments, Roger O. Kollock Jr., James A. Onate, Bonnie Van Lunen

Rehabilitation Sciences Faculty Publications

Context: Insufficient lower extremity strength may be a risk factor for lower extremity injuries such as noncontact anterior cruciate ligament tears. Therefore, clinicians need reliable instruments to assess strength deficiencies.

Objective: To assess the intrarater, interrater, intrasession, and intersession reliability of a portable fixed dynamometer in measuring the strength of the hip and knee musculature.

Design: Crossover study.

Setting: Sports medicine research laboratory.

Patients or Other Participants: Three raters (A, B, C) participated in this 2-phase study. Raters A and B tested 11 healthy college graduate students (2 men, 9 women) in phase 1. Raters A and C tested 26 …

Balance Training Reduces Falls Risk In Older Individuals With Type 2 Diabetes, Steven Morrison, Sheri R. Colberg, Mita Mariano, Henri K. Parson, Arthur I. Vinik

Rehabilitation Sciences Faculty Publications

OBJECTIVE - This study assessed the effects of balance/strength training on falls risk and posture in older individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS - Sixteen individuals with type 2 diabetes and 21 age-matched control subjects (aged 50-75 years) participated. Postural stability and falls risk was assessed before and after a 6-week exercise program.

RESULTS - Diabetic individuals had significantly higher falls risk score compared with control subjects. The diabetic group also exhibited evidence of mild-to-moderate neuropathy, slower reaction times, and increased postural sway. Following exercise, the diabetic group showed significant improvements in leg strength, faster reaction times, …

Dr. Cezanne And The Art Of Re(Peat)Search: Competing Interests And Obligations In Clinical Research, Robyn L. Bluhm, Jocelyn Downie, Jeff Nisker

Philosophy Faculty Publications

Clinician researchers have a number of roles, each of which carries specific obligations. There are times when these obligations may be in competition (up to and including conflict) with each other. Using a narrative case study that describes a group of colleagues discussing their clinical department's participation in an industry-sponsored research protocol, we illustrate a number of the obligations faced by clinician researchers, and discuss how competing interests and obligations can lead to ethical problems. The case study is followed by a discussion of the effect of university-industry relations on competing interests and obligations in both clinical research and the …

Variable Number Of Tandem Repeat Polymorphisms (Vntrs) In The Acan Gene Associated With Pectus Excavatum, Michael W. Stacey, Serina Neumann, Ashley Dooley, Kara Segna, Robert Kelly, Donald Nuss, Anne Kuhn, Michael Goretsky, Annie Fecteau, Aimee Pastor, Virginia Proud

Bioelectrics Publications

No abstract provided.

Increasing The Use Of Booster Seats: A Community-Based Research Project, Michelle Gallina, Amanda Jones, Jane Kim, Habibullah Muhiddin, Natasha Singletary

OUR Journal: ODU Undergraduate Research Journal

The aim of this project was to increase booster seat usage and knowledge of booster seat safety by implementing population-based interventions in the community. To aid in accomplishing the goal, the nursing students utilized the performance of an educational puppet show, educational handouts, and aggregate height and age screening as the interventions. Pre and post tests data were obtained. As a result, there was an increase of the aggregates‟ desire to be in a booster seat. Nurses who take more action in a leadership role by implementing interventions based on the educational needs of the community increased booster seat awareness. …

Childhood Home Injuries: A Nursing Student Approach To Preventing Childhood Home Injuries, Jinging Sparrow, Katherine Carman, Katelyn Kerr, Renee Farmer

OUR Journal: ODU Undergraduate Research Journal

Unintentional injuries are the leading cause of death for children under 14 years of age. Of the unintentional injuries, a significant portion occurs within the home setting. Creating a safe home environment for children has become a focus in current efforts for health promotion and injury prevention. Our objective is to enhance caregivers’ knowledge of home safety thus decreasing the incidence of childhood unintentional injuries. To this end, a series of educational workshops were conducted on poisoning, choking, furniture tip-over, scalds and burns. The material was presented via PowerPoint, videos, posters, handouts, demonstrations and return demonstrations. Verbal pre-and post tests …

Psychosocial Correlates Of Insomnia Severity In Primary Care, Daniel Bluestein, Carolyn M. Rutledge, Amanda C. Healey

Nursing Faculty Publications

Purpose: Insomnia is a substantive primary care issue that leads to adverse outcomes. These can be improved by addressing factors that accentuate insomnia severity. Accordingly, this study identifies correlates of insomnia severity and determines whether these relationships vary with sociodemographic attributes.

Methods: This correlational cross-sectional study was conducted in a hospital-sponsored primary care clinic and 2 urban, academic family practice centers. Participants consisted of 236 patients 18 years old or older with clinically significant insomnia (Insomnia Severity Index scores of 7 or more). Surveys instruments included the Insomnia Severity Index, SF-8 (Medical Outcomes Study SF-8 global health status measure), CES-D …

The Effect Of Culture On Urinary Incontinence: Do We Really Understand?, Karen A. Karlowicz

Nursing Faculty Publications

No abstract provided.

Predictors Of Developmental Screenings For Young Children, Janice Chandler Ranne

Health Services Research Dissertations

This study examines the usefulness of the New Model of Children's Health and its Influences for the identification of predictors for health service effectiveness. Health service effectiveness is measured by probability estimations of whether young children receive formal or informal developmental screenings. Screenings lead to prevention of communication delays in later childhood. Formal screenings with standardized questions are preferred over informal screenings, which are knowledgeable observations. The theoretical framework is a child-centered socio-ecological theory that is untested for use in health service effectiveness studies until the present one. Four developmental concepts of the theoretical framework, social environment, physical environment, biological …

A Benefits-Based Study Of Appalachian Trail Users: Validation And Application Of The Benefits Of Hiking Scale, Barbara Freidt, Eddie Hill, Edwin Gomez, Marni Goldenberg

Human Movement Sciences & Special Education Faculty Publications

Lack of exercise has been linked to poor health issues (e.g., obesity) in American society. National (e.g., Appalachian Trail) and local trails are a potential resource for championing physical activity. To challenge sedentary lifestyle choices and promote more active ones, an understanding of the benefits perceived to be associated with physical and outdoor activities is needed. A total of 454 Appalachian Trail user surveys were collected. Validity analyses and reliability analyses showed the Benefits of Hiking Scale to be an accurate and consistent measure of the dimensions of recreation benefits. Within the improved condition dimension of Benefits, significant differences were …

Aerobic Training Increases Skin Perfusion By A Nitric Oxide Mechanism In Type 2 Diabetes, Sheri R. Colberg, Laura C. Hill, Henri K. Parson, Kathleen S. Thomas, Aaron I. Vinik

Human Movement Sciences & Special Education Faculty Publications

It is well known that a number of locally released vasodilatory and vasoconstrictive compounds can affect skin perfusion. This study investigated the effects of aerobic training on the contribution of nitric oxide (NO), prostaglandins (PG), and endothelial-derived hyperpolarizing factor (EDHF) in stimulated dorsal foot skin perfusion in individuals with type 2 diabetes (T2DM). Ten previously sedentary, older individuals with T2DM (57.0 ± 3.1 years) and nine sedentary controls (53.5 ± 3.2 years) were tested before and after undertaking six months of moderate aerobic training three times weekly in a supervised setting. All subjects underwent measurement of baseline (32°C) and heat-stimulated …

Bisphenol A Blood And Saliva Levels Prior To And After Dental Sealant Placement In Adults, Joyce M. Zimmerman-Downs, Deanne Shuman, Sharon C. Stull, Robert E. Ratzlaff

Dental Hygiene Faculty Publications

Purpose: This study examined the effects of a widely used (Delton® Pit & Fissure Sealant – Light Cure Opaque, DENTSPLY Professional, York, PA) pit and fissure sealant material on bisphenol A (BPA) levels in blood and saliva, among both low and high–dose groups over time.

Methods: A convenience sample of 30 adults from the Old Dominion University population were randomly and evenly divided into 2 independent variable groups: a low–dose group (1 occlusal sealant application) and high–dose group (4 occlusal sealant applications). A 2 group, time series design was used to examine the presence and concentration of BPA in serum …