Medicine and Health Sciences Commons^™

Mental Health Effects Of The Covid-19 Pandemic On Aging Lesbian, Gay, Bisexual, Transgender, And Queer Populations., Iliza Minaya, Samuel Raine, Arkene Levy, Chasity B O'Malley

HPD Articles

INTRODUCTION: The COVID-19 pandemic affected numerous subpopulations of people in unique ways. This study evaluated the impact of the COVID-19 pandemic on the mental health status of Broward County's aging lesbian, gay, bisexual, transgender, and queer (LGBTQ) seniors and identified strengths, weaknesses, and opportunities for interventions to enhance positive mental health outcomes. The study was performed from April 2021 through July 2021.

METHODS: Online surveys measuring anxiety, depression, social support, and resilience were delivered by email to 47 residents of Wilton Manors, Florida. Study data were collected and collated using research electronic data capture tools with bivariate analysis using the …

Benign Acute Childhood Myositis In A Pediatric Patient Post Influenza B Infection, Michael C. Huzior, Brendan P. Chernicki, Lisa Nguyen, Bobby Kumar

HPD Articles

Benign acute childhood myositis (BACM) is a mild and self-limited sudden onset of lower extremity pain during or following recovery from a viral illness. It is characterized by difficulty walking due to severe bilateral calf pain, which usually resolves in three days. It is typically appreciated during times of large influenza outbreaks and epidemics. The most severe complication can be rhabdomyolysis without proper treatment and can lead to renal damage and potential renal failure. There are limited reported cases of BACM and therefore no clear guidelines in the treatment or management of the condition. This case is unique in the …

Thrombotic And Hemorrhagic Complications Following Left Ventricular Assist Device Placement: An Emphasis On Gastrointestinal Bleeding, Stroke, And Pump Thrombosis, Joseph Phan, Kareem Elgendi, Masi Javeed, Juan M. Aranda, Mustafa M. Ahmed, Juan Vilaro, Mohammad Al-Ani, Alex M. Parker

HPD Articles

The left ventricular assist device (LVAD) is a mechanical circulatory support device that supports the heart failure patient as a bridge to transplant (BTT) or as a destination therapy for those who have other medical comorbidities or complications that disqualify them from meeting transplant criteria. In patients with severe heart failure, LVAD use has extended survival and improved signs and symptoms of cardiac congestion and low cardiac output, such as dyspnea, fatigue, and exercise intolerance. However, these devices are associated with specific hematologic and thrombotic complications. In this manuscript, we review the common hematologic complications of LVADs.

Prolonged Antibiotic Use In A Preclinical Model Of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-Like Pathology Via Increased Micro-Rna 21-Induced Pten Inhibition That Is Correlated With Low Host, Ayushi Trivedi, Dipro Bose, Punnag Saha, Subhajit Roy, Madhura More, Jonathan Skupsky, Nancy G. Klimas, Saurabh Chatterjee

HPD Articles

Gulf War (GW) veterans show gastrointestinal disturbances and gut dysbiosis. Prolonged antibiotic treatments commonly employed in veterans, especially the use of fluoroquinolones and aminoglycosides, have also been associated with dysbiosis. This study investigates the effect of prolonged antibiotic exposure on risks of adverse renal pathology and its association with gut bacterial species abundance in underlying GWI and aims to uncover the molecular mechanisms leading to possible renal dysfunction with aging. Using a GWI mouse model, administration of a prolonged antibiotic regimen involving neomycin and enrofloxacin treatment for 5 months showed an exacerbated renal inflammation with increased NF-κB activation and pro-inflammatory …

Nutritional And Wellness Strategies For Neurological And Psychiatric Recovery From Postcovid Syndrome And Post-Acute Sequelae Of Covid-19, Jeffrey Schaefer, Deepesh Khanna

HPD Articles

The post-COVID syndrome was officially recognized as a disability under the Americans with Disabilities Act, indicating that this syndrome has made a significant impact on our populace. Also, post-acute sequelae of COVID-19 (PASC) is a term that describes the long-term health problems that some people experience after being infected with the virus that causes COVID-19. These problems can last for weeks, months, or even years, and can affect various parts of the body, such as the heart, lungs, brain, and blood vessels. This narrative review paper utilized the PubMed database to explore the pathophysiology of post-COVID syndrome's neurological and psychiatric …

The Impact Of Modern Dietary Practices On Cancer Risk And Progression: A Systematic Review, Stephanie Nagy, Stephanie N. Petrosky, Michelle Demory Beckler, Marc M. Kesselman

HPD Articles

Cancer is a leading cause of mortality around the world, despite continued advancements in the management of cancer. Recent research efforts have shifted to evaluating the role that modifiable risk factors play in cancer risk and development, as diet and nutrition have been found to play a significant role in the onset and progression of cancer. As a result, there has been an increasing focus on the impact of dietary modifications on preventing the onset, progression, and reoccurrence of cancer. In this systematic review, data were collected on three common diets, the Mediterranean diet (MD), ketogenic diet (KD), and plant-based …

International Society Of Sports Nutrition Position Stand: Effects Of Essential Amino Acid Supplementation On Exercise And Performance., Arny A. Ferrando, Robert R. Wolfe, Katie R. Hirsch, David D. Church, Shiloah A. Kviatkovsky, Michael D. Roberts, Jeffrey R. Stout, Drew E. Gonzalez, Ryan J. Sowinski, Richard B. Kreider, Chad M. Kerksick, Nicholas A. Burd, Stefan M. Pasiakos, Michael J. Ormsbee, Shawn M. Arent, Paul J. Arciero, Bill I. Campbell, Trisha A. Vandusseldorp, Ralf Jager, Darryn S. Willoughby, Douglas S. Kalman, Jose Antonio

HPD Articles

Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of literature surrounding the effects of essential amino acid (EAA) supplementation on skeletal muscle maintenance and performance. This position stand is intended to provide a scientific foundation to athletes, dietitians, trainers, and other practitioners as to the benefits of supplemental EAA in both healthy and resistant (aging/clinical) populations. EAAs are crucial components of protein intake in humans, as the body cannot synthesize them. The daily recommended intake (DRI) for protein was established to prevent deficiencies due to inadequate EAA consumption. The following conclusions …

Severe Pediatric Open Skull Fracture With Exposed Brain Matter: A Case Report, Sophia Mirkin, Michael Wu, Jessica Colon, Jose J. Burgos, Fernando Perez

HPD Articles

Head trauma in the pediatric population carries a high rate of morbidity and mortality. The major causes of head trauma are related to falls, recreational activities, motor vehicle accidents, and gunshot wounds. Traumatic brain injury (TBI) can occur after severe head trauma and is defined as an alteration in brain function, or other evidence of brain pathology, caused by an external force. Intracranial edema and herniation are common consequences of a TBI in pediatric patients and are commonly relieved via decompressive craniectomy. This case study describes a 13-year-old male presenting to the trauma center after an unhelmeted all-terrain vehicle (ATV) …

Cognitive Decrements In 1991 Gulf War Veterans: Associations With Gulf War Illness And Neurotoxicant Exposures In The Boston Biorepository, Recruitment, And Integrative Network (Bbrain) Cohorts., D Keating, M Krengel, J Dugas, R Toomey, L Chao, L Steele, Lloyd P Janulewicz, T Heeren, E Quinn, N Klimas, K Sullivan

HPD Articles

BACKGROUND: During deployment, veterans of the 1991 Gulf War (GW) were exposed to multiple war-related toxicants. Roughly a third of these veterans continue to exhibit neurotoxicant induced symptoms of Gulf War Illness (GWI), a multi-faceted condition that includes fatigue, pain and cognitive decrements. When studied empirically, both deployed veterans with exposures and those who meet the criteria for GWI are more likely to show deficits in the area of neuropsychological functioning. Although studies have shown cognitive impairments in small sample sizes, it is necessary to revisit these findings with larger samples and newer cohorts to see if other areas of …

Il-34 Exacerbates Pathogenic Features Of Alzheimer's Disease And Calvaria Osteolysis In Triple Transgenic (3x-Tg) Female Mice., Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A. Kacena, Alexandru Movila

HPD Articles

Hallmark features of Alzheimer's disease (AD) include elevated accumulation of aggregated Aβ40 and Aβ42 peptides, hyperphosphorylated Tau (p-Tau), and neuroinflammation. Emerging evidence indicated that interleukin-34 (IL-34) contributes to AD and inflammatory osteolysis via the colony-stimulating factor-1 receptor (CSF-1r). In addition, CSF-1r is also activated by macrophage colony-stimulating factor-1 (M-CSF). While the role of M-CSF in bone physiology and pathology is well addressed, it remains controversial whether IL-34-mediated signaling promotes osteolysis, neurodegeneration, and neuroinflammation in relation to AD. In this study, we injected 3x-Tg mice with mouse recombinant IL-34 protein over the calvaria bone every other day for 42 days. Then, …

Opioid Impacts On Cardiovascular Health, Erjola Toska, Harvey N. Mayrovitz

HPD Articles

The prevalence of opioid use in the current opioid epidemic era has led to a public health emergency due to the ties to mortality and morbidity. Studies have investigated opioids’ impacts on different aspects of cardiovascular health, although there seems to be a lack of a current concise review. Therefore, the aim of this literature review is to provide a summary of the most recent studies from the past decade that postulate a connection between opioids and their impact on cardiovascular health while highlighting conflicting areas among published research. For this literature review, three databases, PubMed (NLM), EMBASE, and Web …

Editorial: Are Mitochondrial Therapeutics The Next Disruptor In Molecular Healthcare?, Benedict Albensi

HPD Articles

No abstract provided.

Anchoring On Hyperglycemia And Sepsis In The Presence Of An Unforeseen Thyroid Storm, Andrew M. Joseph, Monica Karas, Victor H. Camba, Brian M. Martin, John Preece

HPD Articles

Thyroid storm (TS) is a relatively rare but life-threatening complication of an overactive thyroid that can manifest in a myriad of ways due to its multisystem involvement. Due to its relatively high mortality rate, it is essential that TS is recognized and treated promptly. TS can occur due to trauma, drugs, and sepsis. Identifying TS as a diagnosis is challenging to pinpoint due to its similar presentation to more common pathologies like sepsis and diabetic ketoacidosis (DKA). Here, we present a case of a 31-year-old African-American woman with type 2 diabetes mellitus following sepsis secondary to Escherichia coli pyelonephritis and …

An Immunohistochemical Anomaly: A Case Report And Systematic Review Of Myofibroblastoma Of The Breast, Mohamad Kaki, Sarah Klein, Chinar Singh, Breanne Kothe, Jose Martin

HPD Articles

Myofibroblastoma (MFB) is a rare but benign mesenchymal tumor most commonly appearing within breast tissue. Most cases of MFB occur in postmenopausal women and are treated by surgical excision. The diagnosis of MFB is made through immunohistochemical (IHC) analysis, with the most common biomarkers being CD34+, desmin+, smooth muscle actin+, and vimentin+. In this article, we describe a case of an MFB in a premenopausal female with variance from classic IHC findings. We also performed a systemic review of the MFB of the breast. The systemic review compiles the most common IHC findings of MFB, patient demographics, treatment methods, lesion …

Long-Term Evaluation Of Clinical Success And Safety Of Omadacycline In Nontuberculous Mycobacteria Infections: A Retrospective, Multicenter Cohort Of Real-World Health Outcomes., Amer El Ghali, Taylor Morrisette, Sara Alosaimy, Kristen Lucas, Maria G Tupayachi-Ortiz, Raaga Vemula, Carly Wadle, Julie V Philley, Carlos Mejia-Chew, Yasir Hamad, Ryan W Stevens, John D Zeuli, Andrew J Webb, Christina T Fiske, Anahit Simonyan, Christo L Cimino, Mehriban Mammadova, Virginia E Umana, Rodrigo Hasbun, Saira Butt, Kyle C Molina, Michael Thomas, Emily A Kaip, Jeannette Bouchard, Tristan W Gore, Catessa Howard, M Gabriela Cabanilla, Dana J Holger, Jeremy J Frens, Melissa Barger, Aaron Ong, Keira A Cohen, Michael J Rybak

HPD Articles

Infections due to nontuberculous mycobacteria (NTM) continue to increase in prevalence, leading to problematic clinical outcomes. Omadacycline (OMC) is an aminomethylcycline antibiotic with FDA orphan drug and fast-track designations for pulmonary NTM infections, including Mycobacteroides abscessus (MAB). This multicenter retrospective study across 16 U.S. medical institutions from January 2020 to March 2023 examined the long-term clinical success, safety, and tolerability of OMC for NTM infections. The cohort included patients aged ≥18 yr, who were clinically evaluable, and` had been treated with OMC for ≥3 mo without a previous diagnosis of cystic fibrosis. The primary outcome was 3 mo clinical success, …

Impacts Of Skin Color And Hypoxemia On Noninvasive Assessment Of Peripheral Blood Oxygen Saturation: A Scoping Review, Kawaiola C. Aoki, Maya Barrant, Mam Jarra Gai, Marina M. Handal, Vivian Xu, Harvey N. Mayrovitz

HPD Articles

Standard pulse oximeters estimate arterial blood saturation (SaO2 ) non-invasively by emitting and detecting light of a specific wavelength through a cutaneous vascular bed, such as a digit or the ear lobe. The quantity measured at these peripheral sites is designated as oxygen saturation (SpO2 ). Most reliable pulse oximeters are calibrated from measurements of healthy volunteers using some form of oxygen desaturation method. As the degree of inducible hypoxemia is limited, the calibration below achievable desaturation levels is usually extrapolated, leading to potential measurement error at low SaO2 values, especially in highly pigmented skin. Such skin color-related errors (SCRE) …

Group 4 Iti Consensus Report: Patient Benefits Following Implant Treatment In Partially And Fully Edentulous Patients., Martin Schimmel, Mauricio Araujo, Samir Abou-Ayash, Ramona Buser, Supriya Ebenezer, Manrique Fonseca, Lisa J. Heitz-Mayfield, Lucrezia Paterno Holtzman, Porawit Kamnoedboon, Robert Levine, Gerry Mckenna, Sabrina Maniewicz, Flavia Matarazzo, Nikos Mattheos, Panos Papaspyridakos, André Barbisan De Souza, Murali Srinivasan, Charlotte Stilwell, Hans Peter Weber

HPD Articles

OBJECTIVES: The aim of Working Group 4 was to address patient benefits associated with implant dentistry. Focused questions on (a) dental patient-reported outcomes (dPROs), (b) improvement in orofacial function, and (c) preservation of orofacial tissues in partially and fully edentulous patients following provision of implant-retained/supported dental prostheses were addressed.

MATERIALS AND METHODS: Three systematic reviews formed the basis for discussion. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary of the 7th ITI Consensus Conference, taking …

Weight Loss And Competition Weight Comparing Male And Female Mixed Martial Artists Competing In The Ultimate Fighting Championship’S (Ufc) Flyweight Division, Corey Peacock, Justin Braun, Gabriel J. Sanders, Anthony A. Ricci, Charles Stull, Duncan French, Cassandra Evans, Jose Antonio

HPD Articles

Background: Although there is much literature demonstrating weight changes in professional mixed martial arts (MMA) athletes, there is minimal data comparing male and female MMA athletes. Therefore, the purpose of the current study was to compare weight changes between professional male and female MMA athletes leading up to competition. Methods: One hundred and three professional flyweight MMA athletes competing for the Ultimate Fighting Championship (UFC) were used for the study. Weight was obtained at multiple time points leading up to the competition. Two-way ANOVAs and post hoc t-tests were used, and significance was set at p ≤ 0.05. Results: ANOVA …

Social Determinants Of Health Impacting Access To Renal Dialysis For Racial/Ethnic Minorities, Joseph L. Mercen, Kiely Curran, Markeeta T. Belmar, Jaron Sanchez, Ibrahim Hasan, Sahib Kalra, Parth M. Raina, Sahil Patel, Dania Arrechavaleta, Vincent Lee, Paula Anderson

HPD Articles

Although widespread, the burden of disease presented by chronic kidney disease (CKD) is not equally distributed among all demographics. Examining the social determinants of health (SDOH) that relate to barriers to renal dialysis care in CKD can help to prevent future disparities. There has not been a study addressing the social factors that create barriers to care for ethnic minority patients with CKD. The aim of this scoping review is to address the SDOH that affects access to renal dialysis for ethnic minority patients in the United States. This study was based on the protocol published by the Joanna Briggs …

Atherosclerosis Preventive Effects Of Marrubiin Against (Tnf-Α)-Induced Oxidative Stress And Apoptosis, Ailar Nakhlband, Alireza Garjani, Nazli Saeedi, Yadollah Omidi, Samad Ghaffari, Jaleh Barar, Morteza Eskandani

HPD Articles

Introduction: Atherosclerosis is a complicated cascade of inflammatory processes, oxidative stress, and apoptosis, making it the most prevalent cardiovascular disease. The onset and progression of cardiovascular diseases are greatly influenced by oxidative stress. Targeting oxidative stress is an effective strategy for treating such diseases. Marrubiin is a bioactive furan labdane diterpenoid acts as a strong antioxidant to protect against oxidative damage. This study aimed to investigate the protective effects of marrubiin against oxidative stress and apoptosis in a cellular model of the vascular system. Methods: Human umbilical vein endothelial cells were treated with varying concentration of marrubiin and its IC50 …

Post-Hysteroscopy Ruptured Tubo-Ovarian Abscess With Atypical Bacteremia: A Case Report, Jillian H. Linck, Wanda I. Torres, Shailja T. Dayal

HPD Articles

Hysteroscopies are commonly performed in the diagnosis and treatment of patients with abnormal uterine bleeding. Current research suggests a low rate of all types of complications following hysteroscopies. The rate of infectious complications has been reported as exceptionally low. We present a case of tubo-ovarian abscess with Escherichia coli bacteremia and eventual abscess rupture in a 51-year-old gravida 3, para 2012 (G3P2) woman who underwent a hysteroscopy with concurrent polypectomy. The patient had no risk factors that have historically been attributed to the development of post-hysteroscopy infection, such as a history of pelvic inflammatory disease or endometriosis. The patient also …

Cytomegalovirus Esophagitis In An Immunocompromised Patient, Adya A. Ali, Sheela Anasseri, Jaafar Abou-Ghaida, Leslie Walker, Tye Barber

HPD Articles

Cytomegalovirus (CMV) can present with end-organ disease (EOD), particularly in patients with a CD4 cell count <50/mm3. While EOD in immunocompromised patients commonly presents as CMV retinitis (30%) and CMV colitis (5-10%), CMV esophagitis is rare. CMV is the third most common infectious esophagitis following Candida and Herpes Simplex. CMV esophagitis presents with odynophagia, dysphagia, and abdominal pain. Endoscopic exam may reveal large, linear distal esophageal ulcers. Histopathology or serology studies are diagnostic, though serology may be unreliable in the extremely immunosuppressed. Current treatment consists of antivirals such as ganciclovir and valganciclovir. Esophageal disease due to CMV carries a poor prognosis in the immunocompromised. We present the case of a 56-year-old male with a medical history of HIV/AIDS and stage III rectal squamous cell cancer who presented with shortness of breath, weakness, and chronic diarrhea. His HIV was previously well-controlled on antiretroviral therapy. However, due to his malignancy, he was undergoing treatment with chemotherapy and radiation. Initial labs revealed a CD4 count of 42. His clinical course consisted of Escherichia coli septicemia, new-onset atrial fibrillation with a rapid ventricular response, worsening pneumonia, possible metastasis, progressive diarrhea, and potential oropharyngeal candidiasis. Despite several broad-spectrum antimicrobial regimens, he remained symptomatic with new complaints of dysphagia and odynophagia. Eventually, the appearance of vesicular lesions on the lips and a repeat CD4 count of 13 garnered a suspicion of HSV or CMV. This complicated case highlights the necessity for a high index of suspicion of rare manifestations of CMV EOD in an immunocompromised patient presenting with confounding …

Improving Value In Colorectal Cancer Care: An Economic Analysis Of Enhanced Recovery Protocols At A Community Hospital, Lexi Frankel, Amalia D. Ardeljan, Ali Rashid, Abhishek Nair, Kazuaki Takabe, Omar M. Rashid

HPD Articles

Background: Enhanced recovery protocols (ERPs) have been shown to improve the outcomes of gastrointestinal cancer care, leading to reduced morbidity of gastrointestinal treatment and reduced delays in systemic therapy. ERP implementation has also previously shown a reduction in length of stay (LOS) without changing the readmission rate; however, the economic cost associated with these measures has not yet been quantified. The aim of this study was to evaluate the economic costs of ERP implementation for colorectal cancer at a community hospital. Methods: The Diagnostic Related Group (DRG) codes were used to assess costs associated with the hospitalizations of cases in …

Thyroid Predictors Of Postpartum Mood Disorders, Sean Backer, Janeta Yancheva, Camelia Garcia, Deepesh Khanna

HPD Articles

Postpartum mood disorders (PMD) are currently among the leading causes of maternal postpartum morbidity and mortality. PMD include the conditions of postpartum blues (PB), postpartum depression (PPD), and postpartum psychosis. The pathogenesis of PMDs are ambiguous, and there are no reliable prenatal predictive markers despite current research efforts. Even though reliable indicators have not been found, leading ideas suggest an etiology of hormonal fluctuations. Although thyroid markers have long been linked to psychiatric disorders such as major depressive disorder (MDD), how they correlate with PMDs is still unclear. This study aimed to evaluate the pathophysiological link between thyroid function, PMDs, …

The Therapeutic Potential Of Targeting Cardiac Rgs4., Giselle Del Calvo, Teresa Baggio Lopez, Anastasios Lymperopoulos

HPD Articles

G protein-coupled receptors (GPCRs) play pivotal roles in regulation of cardiac function and homeostasis. To function properly, every cell needs these receptors to be stimulated only when a specific extracellular stimulus is present, and to be silenced the moment that stimulus is removed. The regulator of G protein signaling (RGS) proteins are crucial for the latter to occur at the cell membrane, where the GPCR normally resides. Perturbations in both activation and termination of G protein signaling underlie numerous heart pathologies. Although more than 30 mammalian RGS proteins have been identified, each RGS protein seems to interact only with a …

The Development Of Fat Embolism Syndrome (Fes) And Multiple Small Pulmonary Emboli Following Open Reduction Internal Fixation (Orif) Of A Left Femur Fracture: A Case Report, Aaron Hacker, Dylan S. Irvine, Scott Macdougal, Imani Thornton

HPD Articles

Fat embolism syndrome (FES) is a rare but potentially life-threatening complication that can occur following orthopedic procedures, such as long bone fracture repairs. FES is caused by the release of fat globules into the bloodstream, leading to the obstruction of blood vessels and subsequent tissue damage. Pulmonary embolism (PE), a condition in which a blood clot travels to the lungs, is another potential complication of orthopedic procedures due to the mobilization of blood clots during surgery. We report the case of a 56- year-old female who presented to the emergency department with a left femur fracture following a mechanical fall …

Quadruple Valve Replacement In Carcinoid Heart Disease: A Case Report, Maria Beyer, Rishabh Kasarla, Seth Shoap, Erik Beyer

HPD Articles

This report details a rare case of left-sided carcinoid heart disease (CHD). In CHD, vasoactive substances released from carcinoid tumors cause fibrous tissue formation on the right side of the heart. These substances are usually inactivated by monoamine oxidase A in the lungs, safeguarding the left side of the heart. Exceptions include the presence of a patent foramen ovale (PFO), pulmonary metastasis, or elevated serotonin levels. Intriguingly, our patient exhibited significant left-sided involvement without these factors, ultimately requiring a quadruple valve replacement surgery. After eight months post-operation, the patient is stable with no cardiovascular complications. This rare case of CHD, …

A Review Of Federal And Statewide Guidelines And Their Effects On Orthopedics, Johann Braithwaite, John M. Tarazi, Joshua Gruber, Jarret Boroniec, Randy Cohn, Adam Bitterman

HPD Articles

In the past three decades, the use of opioids has risen tremendously. Pain was named the “fifth patient vital sign” in the 1990s, and from that point, opioid usage has continued to grow throughout the 2010s leading to its recognition as a crisis. The United States is responsible for 80% of the global opioid usage while only accounting for less than 5% of the global population. Previously opioids were mostly used to treat acute pain, however, opioids have been most recently used to manage chronic pain as well. The opioid crisis has presented new challenges in treating pain while preventing …

Platelet-Rich Plasma’S Effects In Patients With Androgenetic Alopecia: A Scoping Review, Viktor Kunder, Cristina Munoz, Judd Ivan Palonpon

HPD Articles

Androgenetic Alopecia (AGA), the most common form of hair loss in both males and females, is characterized by the progression of large, pigmented terminal hair to thin, fine vellus hair. In recent years, there has been growing interest in exploring Platelet-Rich Plasma (PR) as a therapeutic option for AGA. PRP is a mixture of numerous cytokines and growth factors that have shown the ability to facilitate wound healing and collagen development. PRP is a mixture of numerous cytokines and growth factors that have shown the ability to facilitate wound healing and collagen development. Utilizing the databases PubMed, Medline EBSCO, and …

The Lasting Effects Of Covid-19 On The Progression Of Metabolic Dysfunction-Associated Steatotic Liver Disease, Sean Backer, Deepesh Khanna

HPD Articles

It is estimated that around 30% of the population living in Western countries has metabolic dysfunctionassociated steatotic liver disease (MASLD), a spectrum of pathology (not attributed to alcohol/substance intake) initiated by steatosis and progression toward inflammation and irreversible fibrosis metabolic dysfunction-associated steatohepatitis (MASH). With inflammation being a key component of the transition to MASH, it raises the question of whether the ongoing COVID-19 pandemic, which has notoriously induced hyperinflammatory states, may influence the progression of MASLD. Specifically, it remains unclear if the potential chronic sequelae of COVID-19 in patients who recovered from it may increase the predisposition for MASH. Since …