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Full-Text Articles in Medicine and Health Sciences
Evaluating Soluble Axl As A Biomarker For Glioblastoma, Daniel Raymond
Evaluating Soluble Axl As A Biomarker For Glioblastoma, Daniel Raymond
All NMU Master's Theses
AXL, a receptor tyrosine kinase, is known to promote malignant phenotypes in various types of cancer. AXL overexpression is commonly observed in glioblastoma and correlates with a worse prognosis. Detectable in most biological fluids, the extracellular domain of AXL, sAXL, is the product of enzymatic cleavage by ADAM10/17. Here we used ELISA, BCA and BCG assays to characterize blood serum from 23 newly diagnosed GBM patients which was collected roughly 24 hours before and after surgery as well as every three months post-surgery, corresponding to follow-up treatment visits. Immunoblotting was used to determine relative AXL expression in 13 patient tumor …
A Cohort Study Investigating Autoantibody Levels During And After Infection With Influenza A Virus, Michelle Collins
A Cohort Study Investigating Autoantibody Levels During And After Infection With Influenza A Virus, Michelle Collins
All NMU Master's Theses
Antinuclear autoantibodies (ANAs) are present in all individuals. In those with autoimmune diseases they are routinely present in elevated levels. Although the nature and development of autoimmune diseases are not fully understood there are many hypotheses as to possible causes of an autoimmune disorder. One possible cause is viral infections. The scope of this thesis study was to examine if autoantibodies levels in individuals without autoimmune disorders increase during or after infection with influenza A virus. Blood was collected from volunteers (n=11) at time intervals of 0, 7, 42 and 63 days, respectively. Antibody levels were measured using ELISA assays …