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Full-Text Articles in Medicine and Health Sciences
Prelimbic Prefrontal Cortical Encoding Of Reward Predictive Cues, Mitchell Spring, Karan R. Soni, Daniel S. Wheeler, Robert A. Wheeler
Prelimbic Prefrontal Cortical Encoding Of Reward Predictive Cues, Mitchell Spring, Karan R. Soni, Daniel S. Wheeler, Robert A. Wheeler
Biomedical Sciences Faculty Research and Publications
Animals appoint incentive value and learn to approach otherwise behaviorally inert stimuli if these stimuli come to predict the delivery of reward. Interestingly, this adaptive Pavlovian learning process has been implicated in behavioral control disorders, such as drug addiction. One brain region implicated in directing conditioned approach behavior is the prelimbic region of the prefrontal cortex. The present study employed in vivo electrophysiology in the prelimbic cortex to characterize the distribution of neural responses to the presence of a cue that had acquired incentive value after being associated with a primary reward. Male rats were trained in a Pavlovian autoshaping …
Chronic Stress Prevents Cortico-Accumbens Cue Encoding And Alters Conditioned Approach, Mitchell Spring, Aaron Caccamise, Elizabeth A. Panther, Bethany M. Windsor, Karan R. Soni, Jayme R. Mcreynolds, Daniel S. Wheeler, John R. Mantsch, Robert A. Wheeler
Chronic Stress Prevents Cortico-Accumbens Cue Encoding And Alters Conditioned Approach, Mitchell Spring, Aaron Caccamise, Elizabeth A. Panther, Bethany M. Windsor, Karan R. Soni, Jayme R. Mcreynolds, Daniel S. Wheeler, John R. Mantsch, Robert A. Wheeler
Biomedical Sciences Faculty Research and Publications
Chronic stress impairs the function of multiple brain regions and causes severe hedonic and motivational deficits. One brain region known to be susceptible to these effects is the PFC. Neurons in this region, specifically neuronal projections from the prelimbic region (PL) to the nucleus accumbens core (NAcC), have a significant role in promoting motivated approach. However, little is known about how activity in this pathway changes during associative learning to encode cues that promote approach. Less is known about how activity in this pathway may be altered by stress. In this study, an intersectional fiber photometry approach was used in …