Medicine and Health Sciences Commons^™

Nanopulse Generators: Their Design And Application To Cancer Therapy Studies, Daniel P. Wernig

Senior Honors Theses

Effective nanopulse generators have become critical in recent decades concerning the study of subcellular affects in response to nanosecond pulsed electric fields. It has been observed that nanosecond duration electric pulses can target intracellular organelles, ultimately leading to cell apoptosis, suggesting the possibility of a new, minimally invasive, low risk cancer therapy methodology. The standard topology for developing a medical nanopulser is the Blumlein “transmission line” approach. This approach relies on the nearly infinitesimal, yet finite amount of time required for an electromagnetic field to propagate down a short transmission line. Prior to design, requirements and constraints must be defined …

Analysis Of Differential Mrna And Mirna Expression In An Alzheimer’S Disease Mouse Model, Amanda Hazy, Matthew Dalton

Other Undergraduate Scholarship

Research has shown that changes in gene expression play a critical role in the development of Alzheimer’s Disease (AD). Our project will evaluate genome-wide RNA expression patterns from brain and blood in an AD mouse model. This analysis will provide insight regarding the mechanisms of AD pathology as well as determine a possible diagnostic tool utilizing RNA expression patterns found in the blood as biomarkers for AD.

Developing A Community Health Worker Program In Chichigalpa, Nicaragua, Monterey Starkey

Other Graduate Research

The city of Chichigalpa, Nicaragua suffers from poor health that causes high rates of morbidity and mortality. Consequently, the people in Chichigalpa could be helped with better water solutions, nutritional status, and overall health knowledge. The people are poor and often do not have access to a doctor due to location or financial reasons. Therefore, a Community Health Program was created to train local community health workers to screen for diseases and to teach the local people preventive care, mainly focusing on water, nutrition, and CKDu. Objectives included assessing the community, recruiting community health workers, developing training curriculum, and training …

Microbial Exposure And Asthma: Applying Strachan’S Hygiene Hypothesis To Nursing Practice, Elisabeth M. Campbell

Senior Honors Theses

The incidence of asthma has risen significantly in recent decades. Asthma is a complex disease process affected by multiple factors including environmental exposure, genetics, epigenetics, and lifestyle. In 1989, the hygiene hypothesis was proposed based on Strachan’s findings suggesting increased exposure to microbes may have protective benefits against allergic rhinitis and eczema. Since that time, research in this arena has exploded as investigators seek to establish a causal link between increased microbial exposure and decreased incidence of allergic disease. The aim of this literature review is to synthesize the current research regarding Strachan’s hygiene hypothesis and identify the nursing implications …

Epigenetic Remodeling In An Imr-32 Cell Line And Transgenic Mouse Model Of Alzheimer's Disease, Matthew S. Baker

Senior Honors Theses

The pathological features of Alzheimer’s disease (AD) have been researched and documented extensively, however the causes of these features are still unknown. The following studies sought to determine if epigenetic methylation alterations contribute to AD. Two studies were sequentially carried out, first using an IMR-32 model and then using a transgenic mouse model overexpressing beta-amyloid. A few assay and confirmation methods were carried out to determine the promoter regions in disease state models undergoing drastic change, and the genes linked to these promoter regions were analyzed to determine significant gene ontology being altered by this epigenetic modification. This data was …

The Baby Friendly Hospital Initiative, Kathryn E. Brackett

Senior Honors Theses

Abstract

The Baby-Friendly Hospital Initiative (BFHI) is a worldwide movement started by the World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) that is aimed at providing hospitals with a certification that guarantees the best possible patient-centered care for mothers and infants. It focuses on breastfeeding as optimal infant nutrition, and implements strategies to encourage and support mothers to breastfeed their infants exclusively for six months after birth. The Ten Steps to Successful Breastfeeding are a set of 10 simple, easy to understand guidelines developed by WHO and UNICEF for implementing this initiative in the hospital setting and …

The Fenzian Unit: Applications To Physical Therapy And Beyond, Jeshua Paul Spadino Mr.

Senior Honors Theses

The field of physical therapy includes many different treatment options in the form of exercises and modalities. The development of a low electrical stimulation signal through the Fenzian unit has provided a new outlook on healing. This device gives information to and receives information from the central nervous system (CNS) through electro-biofeedback and is separated into its own category of modalities. The device can be used to treat a wide range of ailments, all with no adverse effects. This makes it a promising tool in the medical field. It is currently being validated as an authentic medical device through clinical …

The Effects Of Obesity On Human Ambulation: A Lower Joint Analysis, Laura Gilbert

Senior Honors Theses

The effects of obesity on the body are complex and numerous especially when combining the effects on an already multi-faceted and multi-systems action such as human ambulation. This study summarizes a wide range of research performed, which investigated the effects of obesity on human ambulation. The effects are broken down into categories including osteoarthritis, replacement surgery, center of mass, stepping cycle, muscular activation, and specifics of the hip, knee and ankle joints as well as foot changes. The overwhelming majority of studies have found obesity to negatively impact ambulation by shifting center of mass (COM), increasing metabolic cost, decreasing cadence …

Women’S Understanding Of The Effects Of Obesity On Pregnancy, Rachel A. Daniel

Senior Honors Theses

Obesity is a serious issue and is becoming a significant problem around the world. Obesity in general causes and complicates many health problems. As obesity increases in the population at large, the incidence of obesity in pregnancy continues to increase. Obesity during pregnancy has been linked in numerous studies to multiple complications, and the issues and risks have been clearly established. Also becoming pregnant or having multiple pregnancies increases the likelihood of developing obesity. Obese women of childbearing age many times do not even know these risks exist. There is a need to educate these women before they become pregnant, …

Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle

Senior Honors Theses

Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency. Mutated genes such as Fat Mass and Obesity Associated (FTO), Leptin (LEP), Leptin Receptor (LEPR), Melanocortin 4 Receptor (MC4R), Adiponectin C1Q and Collagen Domain Containing (ADIPOQ), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) all contribute to the development of childhood obesity. In the presence of high cholesterol caused by obesity, the genetic condition known as familial hypercholesterolemia is exacerbated. Familial hypercholesterolemia is caused by a …

An Analysis Of The Weight Watchers And Atkins Diets: The Effects Of Calorie Restriction And Nutrition Levels, Heather Brown

Senior Honors Theses

The purpose of this study was to determine the effectiveness of a calorie-restricted diet versus one with restricted food groups. To accomplish this, a survey with 19 participants, age ranging from 25 to 74 years, was taken for people who attempted Weight Watchers, a calorie-restricted diet, and Atkins, a low-carbohydrate diet. The success rates of each of these diets will be compared and analyzed in this study. Participants reported short-term and long-term weight loss results. For the data analysis, descriptive statistics and two independent t-tests were performed. For short-term weight loss on Atkins, M = 20.25, and on Weight …

Possible Psychosocial Benefits Of Having A Sibling With A Disability, Jenna M. Talbott

Senior Honors Theses

Possible psychosocial benefits resulting from exposure to siblings with disabilities are investigated in the current study. Previous literature has generally overlooked the possibility of psychosocial benefits by exclusively focusing on the negative effects of having a sibling with disabilities. Contact theory suggests that the increased exposure to individuals with disabilities should increase positive attitude toward those who are struggling with disadvantages. This investigation hypothesized that this tendency would be manifested as elevated empathy and compassion in individuals who have siblings with disabilities, and that these traits would be influenced by certain demographic variables. A survey was distributed, and the responses …

Galactose-1-Phosphate Uridyl Transferase (Galt) And Galactosemia A Review Of Galt Function And Current Theories On Galactosemia Pathogenesis, Lydia R. Rehrer

Senior Honors Theses

All living organisms depend on the metabolism of carbohydrates for energy and the biosynthesis of necessary glycoconjugates. One of these carbohydrates is the monosaccharide galactose. Galactose is metabolized by humans through the Leloir pathway of galactose metabolism, which contains three enzymes to modify galactose so that it can be incorporated into glycolysis for the production of cellular energy. The middle enzyme of this pathway, galactose-1-phosphate uridyltransferase, produces uridine diphosphogalactose (UDP-gal) from galactose-1-phosphate (gal-1P), and a deficiency of this enzyme results in the human disease galactosemia. Galactosemia is diagnosed soon after an infant begins feeding, and although a galactose-restricted diet eliminates …

Selling Life To Abortion-Seekers: A Content Analysis Of Passive And Active Persuasion In Crisis Pregnancy Center Marketing, Alexander Kocman

Masters Theses

For supporters of the pro-life cause, crisis pregnancy centers (or CPC's) have become the "darlings of the movement," according to the New York Times (Belluck, 2013), offering women with unplanned pregnancies free advice, information, classes, childcare, and needed supplies. For abortion advocates, such establishments are intended to seduce vulnerable abortion-seekers into a situation where they will be counseled out of an abortion and possibly even proselytized. Yet for as much controversy as exists in the news media, medical community, and legal realm about CPC's, there is an unsettling lack of understanding of how--and why--CPC's market themselves the way they do. …

The Gut Reaction: How The Intestinal Microbiota Respond To Citrobacter Rodentium Colonization, Cassandra Black

Senior Honors Theses

The human intestine hosts a diverse community of bacteria known as the intestinal microbiota. The intestinal microbiota have a symbiotic relationship with the host organism. Current research does not clearly define the effect these commensal microorganisms have on the overall maintenance of gastrointestinal health, including protection from the invasion and pathogenesis of foreign bacteria known as pathogens. EHEC O157:H7 causes severe sickness and can be life-threatening, but is difficult to study in vivo. One challenge is that EHEC does not colonize the preferred animal model for human GI studies: the murine intestine. However, the murine pathogen Citrobacter rodentium has …

Understanding Ultramarathoners: Identifying Markers Of Success In Ultras Through An Objective Survey Of Ultramarathoners, Renee A. Cabalka Mrs.

Senior Honors Theses

An ultramarathon (ultra) is defined as a race longer in time or distance than a marathon. Studies have been done to identify factors, which contribute to successful completion of other ultra endurance events. The purpose of this study was to determine factors that contribute to the successful completion of an ultramarathon by collecting data via an objective survey. The subjects of this survey were participants in the 2013 Mountain Masochist Trail Race (MMTR) 50 miler. The survey included factors such as gender, age, height, weight, body mass index (BMI), training age, and ultra experience. The survey data was collected and …

Abo-Incompatible Organs A Viable And Necessary Source For Transplants, Rachel J. Macpherson

Senior Honors Theses

Despite the astounding technological advancements of modern society, failure to receive a timely organ transplant accounts for the death of approximately 18 U.S. citizens each day. As the population continues to expand, so does the shortage of donor-recipient matching organs. In order to alleviate this deficit, medical researchers have addressed the most common barrier that accounts for donor-recipient denial: blood typing. Within recent years, immunological understanding has progressed leading researchers to believe ABO-incompatible organs may be a viable source for transplantation with unparalleled potential to expand donor availability. It is the intent of this review to increase public awareness of …

Impact Of Family Presence In The Healthcare Setting, Michelle Mccabe

Senior Honors Theses

Family presence at the patient’s bed side is promoted and encouraged within the healthcare arena. Healthcare staff strive for reports of satisfaction from patients and families. Positive and negative outcomes of family presence on units within the hospital have been assessed, with suggestions for visitation practices and solutions for common concerns. Positive patient outcomes, including accelerated recovery time, increased reports of comfort, and decreased duration of hospital stay are the ultimate goals of hospital care. Research shows that patient outcomes are impacted greatly by family presence. Patient- and family-centered care represent the future model of healthcare. Knowledge of these policies …

A Pilot Study On The Effects Of Exercise On Depression Symptoms Using Levels Of Neurotransmitters And Eeg As Markers, Timothy H. Barclay, Scott Richards, James Schoffstall, Chad Magnuson, Christine Mcphee, Josh Price, Stephen Aita, Audrey Anderson, Dan Johnson, Jerry Price

Faculty Publications and Presentations

Context: The prescribing of exercise by physicians has become a popular practice, yet the effectiveness of exercise on symptoms of depression is difficult to determine due to a lack of randomized controlled trials with clinical populations. Reports also indicate that only a small percentage of physicians advise their patients regarding exercise and confusion still exists as to how much and what types are best. Aims: To understand the mechanisms that make exercise a viable treatment in depression. Settings and Design: This study employed a six‑week, two group, single‑level trial, pre‑ and posttest design using self‑report of symptoms, blood …

The Benefits Of Breastfeeding, Avery Kordus

Senior Honors Theses

Breastfeeding research is plentiful, and the majority of the literature shows that breast milk is the superior form of infant nutrition except in the rare circumstances of infant metabolic disorders, maternal drug use, or positive HIV status. In comparison to formula, breast milk provides improved cognition, development, behavior, bonding, nutrition, digestion, immunity, and long-term health with fewer diseases and conditions in infants. Mothers are benefited by breastfeeding through bonding, faster weight loss, and reduction in certain cancers and conditions. Breast milk contains the proper amount of carbohydrates, fats, proteins, vitamins, and minerals, and is also specialized for each infant and …