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Full-Text Articles in Medicine and Health Sciences
Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle
Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle
School of Medicine Faculty Publications
No abstract provided.
Nf-Kb (P50/P65)-Mediated Pro-Inflammatory Microrna (Mirna) Signaling In Alzheimer's Disease (Ad), Walter J. Lukiw
Nf-Kb (P50/P65)-Mediated Pro-Inflammatory Microrna (Mirna) Signaling In Alzheimer's Disease (Ad), Walter J. Lukiw
School of Medicine Faculty Publications
No abstract provided.
Sars-Cov-2 Neuroinvasion, Inflammatory Neurodegeneration And Alzheimer's Disease, Yuhai Zhao, Walter J. Lukiw
Sars-Cov-2 Neuroinvasion, Inflammatory Neurodegeneration And Alzheimer's Disease, Yuhai Zhao, Walter J. Lukiw
School of Medicine Faculty Publications
No abstract provided.
Fission Impossible: Stabilized Mirna-Based Analogs In Neurodegenerative Disease, Walter J. Lukiw
Fission Impossible: Stabilized Mirna-Based Analogs In Neurodegenerative Disease, Walter J. Lukiw
School of Medicine Faculty Publications
No abstract provided.
Exosomes From Adipose-Derived Stem Cells Alleviate Myocardial Infarction Via Microrna-31/Fih1/Hif-1Α Pathway, Dihan Zhu, Yang Wang, Miracle Thomas, Keasiah Mclaughlin, Babayewa Oguljahan, Joshua Henderson, Qinglin Yang, Y Eugene Chen, Dong Liu
Exosomes From Adipose-Derived Stem Cells Alleviate Myocardial Infarction Via Microrna-31/Fih1/Hif-1Α Pathway, Dihan Zhu, Yang Wang, Miracle Thomas, Keasiah Mclaughlin, Babayewa Oguljahan, Joshua Henderson, Qinglin Yang, Y Eugene Chen, Dong Liu
School of Graduate Studies Faculty Publications
Our previous study has revealed that exosomes from adipose-derived stem cells (ASCs) promote angiogenesis in subcutaneously transplanted gels by delivery of microRNA-31 (miR-31) which targets factor inhibiting hypoxia-inducible factor-1 (FIH1) in recipient cells. Here we hypothesized that ASC exosomes alleviate ischemic diseases through miR-31/FIH1/hypoxia-inducible factor-1α (HIF-1α) signaling pathway. Exosomes from ASCs were characterized with nanoparticle tracking analysis, transmission electron microscopy, and immunoblotting analysis for exosomal markers. Results from immunoblotting and laser imaging of ischemic mouse hindlimb revealed that miR-31 enriched ASC exosomes inhibited FIH1 expression and enhanced the blood perfusion, respectively. These effects were impaired when using miR-31-depleted exosomes. Immunohistochemistry …
Regulation Of Microrna Expression In Sleep Disorders In Patients With Epilepsy, Edyta Dziadkowiak, Justyna Chojdak-Łukasiewicz, Piotr Olejniczak, Bogusław Paradowski
Regulation Of Microrna Expression In Sleep Disorders In Patients With Epilepsy, Edyta Dziadkowiak, Justyna Chojdak-Łukasiewicz, Piotr Olejniczak, Bogusław Paradowski
School of Medicine Faculty Publications
The effects of epilepsy on sleep and the activating effects of sleep on seizures are well documented in the literature. To date, many sleep-related and awake-associated epilepsy syndromes have been described. The relationship between sleep and epilepsy has led to the recognition of polysomnographic testing as an important diagnostic tool in the diagnosis of epilepsy. The authors analyzed the available medical database in search of other markers that assess correlations between epilepsy and sleep. Studies pointing to microRNAs, whose abnormal expression may be common to epilepsy and sleep disorders, are promising. In recent years, the role of microRNAs in the …