Medicine and Health Sciences Commons^™

Analysis Of Growth And Prevalence Of Malnutrition During Total Parenteral Nutrition Weaning: A Methodological Demonstration, Lauren Ashley Kane

Masters Theses

Background: Total Parenteral Nutrition (TPN) is a life-saving intervention which provides nutrition to premature infants with immature gut functioning. Though essential for nutrition provision in the first days of life, TPN is not without risk. Therefore, it is important to introduce feedings into the gut and to wean off TPN when able. During this weaning phase, calorie and protein deficits have been observed to occur. Very few studies have investigated TPN weaning periods, and there are no studies on malnutrition associated with the TPN weaning period in premature infants.

Methods: This study employed a retrospective chart review, with medical …

The Relationship Between Neuroticism, Self-Esteem, And Disordered Eating Attitudes: Examining The Health At Every Size Theory, Liana Cho

Masters Theses

Background. In the modern day treatment of overweight/obesity, conflicting recommendations regarding treatment have been released by the Academy of Nutrition and Dietetics (AND) and advocates of the Health at Every Size (HAES) movement. While the AND have indicated their support for self-monitoring practices, such as keeping a food diary or tracking calories, HAES advocates have claimed that these restrictive practices may result in increased disordered eating tendencies and poor self-esteem.

Subjects. The participants for this study included 410 students at Grand Valley State University. Almost 80% of participants were female, and just over 85% of participants identified as white. …

The Relationship Between Feeding Type And Temporomandibular Joint Morphology In Superfamily Musteloidea, Travis L. Garvin

Masters Theses

Many studies have focused on the soft tissue analysis of carnivores and have demonstrated a relationship between feeding biomechanics and feeding types. Herbivores and omnivores rely heavily on anteroposterior and helical movement of the mandible and teeth for the breakdown of fibrous foods resulting in a flat mandibular fossa while the function of the carnivore TMJ is different, as they need a much stable joint for ripping and tearing of the flesh. I aim to look at whether the bony morphology of the temporomandibular joint (TMJ) can be directly related to feeding type, specifically in the superfamily Musteloidea. I sampled …

Is Tpmt Testing A Predictor Of Duration Of Use Or Long-Term Benefit Of Thiopurine Agents?, Shatoya R. Wilson

Masters Theses

Background: Inflammatory Bowel Disease (IBD) affects as many as 1.3 million Americans and includes both ulcerative colitis (UC) and Crohn’s disease (CD). Recent practices have moved towards using immunomodulators early in the course of disease to prevent disease progression. Patients have shown improved outcomes on immunomodulators compared to aminosalicylates, and reduced risk for tachyphylaxis compared to corticosteroid treatment. Thiopurine agents such as azathioprine and 6-mercaptopurine are immunomodulators often used to treat IBD. Unfortunately, many patients experience cytotoxicity from thiopurine use. Recent studies have shown that patients deficient in thiopurine-S-methyltransferase (TMPT), produce an overabundance of the therapeutic end product, 6-thioguanine nucleotide …

The Effect Of Alpha-Linolenic Acid (Ala) On Endothelial Cell Expression Of Connexin43, Benjamin Pichette

Masters Theses

Atherosclerosis is the leading cause of cardiovascular diseases like myocardial infarctions and strokes. The formation of these atherosclerotic plaques occurs through localized inflammatory responses in blood vessels. Epidemiological evidence suggests omega-3 fatty acids (FAs) decrease vascular inflammation. The omega-3 FAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce inflammation through pathways that may include the free fatty acid-4 (FFA-4) receptor. While EPA and DHA are well studied, less is known about the essential omega-3 FA from which they are synthesized: alpha-linolenic acid (ALA). Thus, this study will investigate whether ALA can activate the FFA-4 receptor and thereby contribute to anti-inflammatory …

Effects Of Eicosapentaenoic Acid (Epa) On Mouse Endothelial Cell Health, Spencer C. Pageau

Masters Theses

Cardiovascular disease is the number one killer of adults in the US (~800,000 lives every year:1 in 3 deaths). Evidence suggests omega-3 fatty acids like eicosapentaenoic acid (EPA), found in fish oils, reduce the risk of developing cardiovascular diseases. Many of these diseases are caused by atherosclerotic plaque development in vessels due to endothelial cell damage initiating inflammatory responses. Recent work argues omega-3 fatty acids stimulate anti-inflammatory responses by binding to Free Fatty Acid (FFA) receptors. Inflammatory responses in endothelial cells alter the expression of many proteins that affect the function of those cells. In particular, gap junction protein (connexin: …

Effects Of Chronic Atrazine Exposure On Male Reproductive Function In Sprague Dawley Rats, Josh Quinn

Masters Theses

Estrogens, in addition to testosterone, are much more physiologically relevant to normal sperm production in the testis and overall male fertility than previously thought. Current use herbicides, such as atrazine, are known endocrine disruptors and have been suggested to disrupt male reproductive health. The purpose of this study was to investigate the effect of chronic atrazine exposure on male reproductive function in Sprague Dawley rats. Three groups of rats were treated until 7 months of age. The first group was the control vehicle and given only water. The second group was given a low dose of atrazine (0.1 mg/kg) and …

Use Of The Montreal Cognitive Assessment As An Early Indicator Of Tumor Progression In Patient With Stage Iii And Iv Gliomas, Eric David Laney

Masters Theses

Patients diagnosed with high grade glioma have a short life expectancy due to rapid progression of disease following and/or during treatment. Magnetic resonance imaging (MRI) is the primary method of surveying tumor progression, but is costly, lengthy in duration and often uncomfortable for the patient. An alternative to MRI that is cost efficient and patient friendly is of great interest to the medical community. If this alternative could also provide advanced notification of disease progression, then this patient population would have the opportunity for earlier treatment and the potential for greater efficacy. To pursue this concept, we assessed whether the …

Incidence, Clinical Manifestations And Risk Factors Of Acute Rheumatic Fever: A Systematic Review And Meta-Analysis Of The Global Perspective, Jessica Fritzler

Masters Theses

Acute Rheumatic Fever (ARF) is a system-wide disease in which chronic, wide spread inflammatory changes occur in response to a group A streptococcal (GAS) infection that most often affects children and adolescents and those from developing countries. The aim of this study is to calculate the global incidence of ARF and identify the frequencies of major and clinical manifestations and risk factors globally to provide a better indication of the burden of disease and additional information on the dispersion of manifestations and risk factors. A meta-analysis was conducted by pooling cross-sectional and cohort studies, and Morbidity and Mortality Weekly Reports …