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Full-Text Articles in Medicine and Health Sciences
Nicotine Sensitization And Brain-Derived Neurotrophic Factor Content In Adolescent Rats Neonatally Treated With Quinpirole., Addie Roberts
Nicotine Sensitization And Brain-Derived Neurotrophic Factor Content In Adolescent Rats Neonatally Treated With Quinpirole., Addie Roberts
Undergraduate Honors Theses
Neonatal treatment of quinpirole in rats increases dopamine D2-like receptor sensitivity over the animal’s lifetime, a phenomenon referred to as D2 priming. Male and female Sprague-Dawley rats were given quinpirole (1mg/kg, i.p.) or saline on postnatal days (P)1-21. After habituation to a locomotor arena on P29-31, beginning P33, animals were administered nicotine (0.3 mg/kg, 0.5 mg/kg, or 0.7 mg/kg, i.p.) or saline and placed into a locomotor arena for behavioral testing every second day for a total of 9 treatments. The results showed that adolescents neonatally treated with quinpirole produced more enhanced sensitization to nicotine than controls. Brains tissues were …
Knowledge Of The Effects Of Alcohol On Fetal Development Among Women Of Childbearing Age., Mary Bales
Knowledge Of The Effects Of Alcohol On Fetal Development Among Women Of Childbearing Age., Mary Bales
Undergraduate Honors Theses
While Fetal Alcohol Syndrome Disorder is a recognized problem with alcohol ingestion during the formation of facial features, Fetal Alcohol Spectrum Disorders are not as widely recognized. These disorders result from exposure to alcohol throughout pregnancy when the brain and nervous system are developing. The resulting disorders include attention deficit disorders, social disorders, inappropriate behaviors, learning disorders, and intellectual disability. The incidence of children with alcohol-related disorders is increasing as evidenced by children needing special services in the educational systems. It is unknown how much alcohol ingestion is safe during pregnancy or how genetic factors are involved in the development …
7,8-Dihydroxyflavone, A Selective Tyrosine Kinase Receptor B Agonist And Bdnf Mimic, Promotes Angiogenesis., Jeremy Williams
7,8-Dihydroxyflavone, A Selective Tyrosine Kinase Receptor B Agonist And Bdnf Mimic, Promotes Angiogenesis., Jeremy Williams
Undergraduate Honors Theses
7,8-dihydroxyflavone (7,8-DHF), which is a member of the flavonoid family, is a selective tyrosine kinase receptor B (TrkB) agonist that has neurotrophic effects in various neurological diseases such as ischemic stroke and Parkinson’s disease [3]. In this study, we assessed the angiogeneic effect of 7,8-DHF in endothelial cells derived from resistance vessel of the brain. Angiogenesis by 7,8-DHF is an important factor that helps prevent and treat various ischemic diseases. In this study, we found that rat RV cells used in the experiment possess the TrkB receptor. Our data also demonstrates that 7,8-DHF is able to stimulate cell proliferation in …
Brain-Derived Neurotrophic Factor Levels In D2 Receptor Primed Adolescent Rats Given Twice Daily Nicotine Administrations., Josie Minnigh
Brain-Derived Neurotrophic Factor Levels In D2 Receptor Primed Adolescent Rats Given Twice Daily Nicotine Administrations., Josie Minnigh
Undergraduate Honors Theses
Nicotine use is very prevalent in the schizophrenic population, which is a 2.5 fold greater than the general population. In the present study, the drug quinpirole (dopamine D2/D3 agonist) or saline was given neonatally to 25 Sprague-Dawley male and female rats. Rats were randomly assigned to condition. Beginning postnatal day 33 animals were given twice daily administrations of nicotine (0.5 mg/kg free base). After the first of the daily injections they were placed in a locomotor arena every other day for behavioral testing. One day after behavioral testing, the dorsal striatum and nucleus accumbens were removed for brain-derived neurotrophic factor …
Visitor Hand-Washing Compliance According To Policies And Procedures At A Regional Neonatal Intensive Care Unit., Desiree Raynor
Visitor Hand-Washing Compliance According To Policies And Procedures At A Regional Neonatal Intensive Care Unit., Desiree Raynor
Undergraduate Honors Theses
Hospital-acquired infections cost hospitals approximately $30.5 billion per year and also result in longer hospital stays, chronic conditions, and even death with associated malpractice costs. According to the Centers for Disease Control and Prevention, hand hygiene is a simple, effective way to prevent illness and infection. The purpose of this research was to determine if visitors to a neonatal intensive care unit (NICU) in a regional medical center comply with hand-washing policies and procedures. If NICU visitors wash their hands properly, they can prevent potentially fatal infections from spreading to patients, healthcare workers, and unaffected family members. Hand-washing compliance has …