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Endothelial Heat Shock Protein A12b And Yes-Associated Protein Cooperatively Promote Angiogenesis Following Myocardial Infarction, Min Fan

Electronic Theses and Dissertations

Heart failure after myocardial infarction (MI) remains the leading cause of mortality among all cardiovascular diseases globally. Angiogenesis plays a critical role in cardiac functional recovery after MI. Heat shock protein A12B (HSPA12B) is predominately expressed in endothelial cells and required for angiogenesis. Yes-associated protein (YAP) has been reported to promote tumor angiogenesis.

In the present study, we investigated the cooperative role of HSPA12B and YAP in angiogenesis following myocardial ischemic injury. Endothelial specific deficiency of HSPA12B (eHspa12b^-/-) or YAP (eYap^-/-) impairs angiogenesis and exacerbates cardiac dysfunction after MI, when compared with wild type …