Medicine and Health Sciences Commons^™

Modeling Immune System Dynamics During Hiv Infection And Treatment With Differential Equations, Nicole Rychagov

CODEE Journal

An inquiry-based project that discusses immune system dynamics during HIV infection using differential equations is presented. The complex interactions between healthy T-cells, latently infected T-cells, actively infected T-cells, and the HIV virus are modeled using four nonlinear differential equations. The model is adapted to simulate long term HIV dynamics, including the AIDS state, and is used to simulate the long term effects of the traditional antiretroviral therapy (ART). The model is also used to test viral rebound over time of combined application of ART and a new drug that blocks the reactivation of the viral genome in the infected cells …

The Role Of Porn Literacy In Comprehensive Sex Education To Reduce Endorsements Of Gendered Sexual Violence And Support Healthy Adolescent Development, Kiana Harnish

Scripps Senior Theses

Due to stigmatization of sex and insufficient sexual education, modern-day adolescents rely on free online pornography as a source of education about sex and relationships. This thesis provides a review of the connections between adolescent porn use and the socialization of sexual violence (SV) and coercion against women, comprehensive sex education (CSE) and healthy adolescent sexual development, and porn literacy (PL) and sexual attitude or behavior changes. Porn literacy aims to equip adolescents with tools to critically analyze sexualied media and messages, to empower them to make informed decisions to engage or disengage with porn and their sexuality in a …

The Future Of Community Health Center Executive Leadership A Mixed-Method Formative Evaluation, Lizbeth Bayardo Cardenas

CGU Theses & Dissertations

This is a formative evaluation study of the California Primary Care Association's (CPCA) Leadership Equity Program, developed in response to the need for greater alignment between the communities accessing care provided by Community Health Centers and the representativeness of their future executive leaders. Community Health Centers (CHC) are a critical network of primary healthcare systems that deliver high-quality, comprehensive healthcare services to patients predominantly from under-resourced and marginalized communities of color. The study used a mixed-method concurrent triangulation design to describe how participants perceived the program achieved its goals and objectives using Kirkpatrick's Model and systems thinking. The study integrated …

A Digital Transformation Framework For Biopharma Manufacturing, Frederick K. Johnson

CGU Theses & Dissertations

In the current climate of economic uncertainty and social unrest, biopharmaceutical (biopharma) companies face the challenges of changes in consumer behavior, cyber threats, and technological advancement. At the same time, their top priorities are global market growth, strengthening R&D, and undergoing digital transformation (Dx). Given these developments, biopharma organizations must choose a Dx framework as they engage in the digital transformation of their businesses in this high-stakes environment. However, there are significant problems with existing Dx frameworks. Most models are generalized frameworks designed to sell consulting services. Some focus on the enterprise or the manufacturing operations, but not both, and …

Burning Bright Or Burning Out: A Qualitative Investigation Of Leader Vitality And Accompanying Practitioner Article, Jamie Shapiro

CGU Theses & Dissertations

Leaders of organizations have incessant demands placed on them, including cultivating teams, building culture, and increasing the bottom line, in addition to caring for followers’ wellbeing and thriving. Numerous resources are required to meet these continuous demands, and vitality is one of the most valuable. Through interviewing 20 of the most influential and pressured leaders of Fortune 1000 companies, this qualitative study answers three important questions: what drains vitality, what fosters it, and how do leaders most effectively utilize vitality for followers? The results shed light on psychological mechanisms that drain leaders’ vitality, including emotional labor, self-control, loss of job …

When Leaders Use Self-Uncertainty Strategically: Consequences For Intergroup Leadership And Identity Confirmation Dynamics, Alison Young

CGU Theses & Dissertations

Framed by the social identity theory of leadership, one question that is beginning to receive attention is how intergroup leaders can lead across distinct subgroups and improve inter-subgroup relations without provoking social identity-related concerns (e.g., subgroup identity distinctiveness threat). Past studies have found that leaders can use their rhetoric and boundary spanning behavior to meet their members’ identity needs and garner support. In addition, the self-uncertainty literature has suggested that leaders can strategically elevate and resolve members’ self-uncertainty through their rhetoric. The current research proposed that members who felt uncertain about their subgroup’s identity would have more favorable evaluations of …

Understanding The Relationship Between Undergraduate Students’ On-Campus Employment Status And Their Reported Sense Of Belonging To The Campus Community Post The Covid-19 Pandemic, Samantha Martinez

CGU Theses & Dissertations

Belonging has been studied for decades with many researchers concluding that humans have an inherent need to belong. Although each person’s level of need to belong differs, it is a deeply rooted human motivation that impacts a person’s feelings, thoughts, and behaviors. Individuals develop a sense of belonging when they feel connected to others. The postsecondary journey allows for unique experiences and opportunities that foster a sense of belonging, which can assist college students to flourish in many aspects of their lives. Research has shown that belonging significantly impacts student well-being and academic achievement, making the topic imperative to continue …

Potential Mechanism Of 5-Ala Treatment Against Feline Infectious Peritonitis Virus Infection By Downstream Metabolite Ppix, Carissa V. Napier

Scripps Senior Theses

Feline coronavirus (FCoV) infection is ubiquitous in domestic cats, and up to 12% of FCoV-infected cats may succumb to Feline Infectious Peritonitis (FIP). FIP is a highly lethal infectious disease caused by FIP virus (FIPV), the virulent biotype of FCoV. It is difficult to properly diagnose FIP, and to this date, there is no effective FCoV vaccine nor licensed therapeutic for FIPV. Considering the threat FIP poses to feline health, there is a demand from both owners and veterinarians for a proper therapeutic to effectively treat the infection. 5-aminolevulinic acid (5-ALA) is a highly bioavailable amino acid that is naturally …

Combatting Bacterial Infections: The Efficacy Of Poly-Gamma-Glutamic Acid On The Prevention Of Nasopharyngeal Infections Among Individuals With Cleft Lip And Palate, Florence Pun

Scripps Senior Theses

Cleft lip and palate (CLP) is a medical condition where children are born with an unfused lip and palate. While surgery is required to fuse the lip and palate, there are other conditions that children with CLP face after surgeries, such as otitis media (OM), speech impediments, and difficulty breathing. Particularly, OM occurs frequently in individuals with CLP because the tensor veli palatini muscles cannot open the Eustachian tube frequently and ventilate the middle ear properly, even after surgery. This thesis is a research proposal to evaluate whether γ-PGA can be used in nasal washes to safely prevent nasopharyngeal infections …

An Analysis Of Water Quality At Orange County, California Beaches, Naomi Meurice

Pomona Senior Theses

Beaches in Southern California are highly recreated by residents and visitors, making beaches socially and economically important. Public health departments in coastal communities are in charge of measuring water quality and ensuring it is safe for users. Research in the past has indicated that beach water quality gets worse after storms, with bacteria levels jumping on the day of a storm and staying high for up to five days. Studies have shown these spikes in bacteria to be associated with storm runoff, with beaches closer to runoff discharge locations experiencing more impact. However, prior research has not considered the period …

Effect Of Poor Menstrual Health On Uti Diagnosis, Michelle Muturi

Pitzer Senior Theses

Urinary Tract infections (UTIs) are microbial invasions of the urinary tract because of abnormal pathogen growth. They have short term symptoms like abdominal pain, fever and urinary frequency. Khayelitsha is a township that has a population of 2.4 million, 52% of which are women. This area is shaped by poor governance in South Africa that exacerbated medical issues due to a lack of resources. With lack of sanitary pad accessibility and knowledge of proper hygiene practices during the menstrual cycle, women are getting infected with UTIs 2-3 times a year. With an increase in antimicrobial resistance patterns, areas like Khayelistsha …

Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang

Scripps Senior Theses

Pituitary neuroendocrine tumors (PitNETs) are tumors of the pituitary gland. Although most are benign, they can cause severe morbidity if compression of surrounding tissue and/or endocrinopathies occur.

Aggressive PitNETs are notably detrimental and difficult to predict, and their effects are further exacerbated by challenges in treatment. Although histological studies can detect certain markers of tumor aggressiveness, they are insufficient at wholly predicting PitNET aggressiveness, making the clinical behavior of PitNETs challenging to determine. Since treatment of aggressive tumors also remains suboptimal, this further results in negative impacts on health and quality of life.

Genetic markers, such as copy number variations …

Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner

Scripps Senior Theses

Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …

Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann

Scripps Senior Theses

Growing up in an urban food desert can significantly affect children's development, health, and well-being (Jencks et al., 1990; Leventhal et al., 2000). Compared to their more affluent peers, youth living in low-socioeconomic urban neighborhoods are at greater risk of experiencing poor-quality diets, food insecurity, unhealthy body weights, and mental health problems (Duncan et al., 1997; Sampson et al., 1997). Moreover, children living in food-insecure households are more likely to consume calorically dense diets high in trans fat and added sugar, putting them at risk for poor health, childhood obesity, and chronic, diet-related diseases as adults (Nielsen et al., 2002). …

Utilizing Amr Surveillance Data To Analyze Trends In Escherichia Coli Antibiotic Resistance Levels In The South African Provinces Of Gauteng And The Eastern Cape, Celia Maris

Scripps Senior Theses

Antimicrobial resistant bacterial pathogens pose an ongoing threat to universal public health by causing more severe manifestations of infectious diseases, leading to an increase in healthcare expenditures and higher global mortality rates. Therefore, developing strategies to combat bacterial antimicrobial resistance (AMR) is vital for the future of human health. One promising strategy is through the utilization of AMR surveillance programs. This study focused on using AMR surveillance data from South Africa to analyze changes in Escherichia coli resistance levels to numerous antibiotics between January 2012 and December 2022 in Gauteng Province and the Eastern Cape Province. The study aimed to …

Dementia And The Fragility Of Self: Navigating Ethical Considerations In Medical Decision-Making, Grace Sauers

Scripps Senior Theses

As the global population ages, the incidence of degenerative memory disorders such as Alzheimer's and dementia is expected to rise. The frequency of complex medical decision-making challenges for these patients will subsequently increase. It is now common practice for patients to provide advance directives outlining the care they wish to receive; in the case they are deemed incompetent to perform adequate decision making. However, patients with dementia occasionally express wishes contrary to those stated in their advance directives. This divergence creates ambiguity about which wishes should be honored and for who those wishes are being honored for. I aim to …

Transcranial Direct Current Stimulation (Tdcs) To Improve Lower Limb Motor Recovery Following Stroke: A Review And Study Proposal, Jessica Fantz-Sands

Scripps Senior Theses

Strokes are the result of restricted blood flow to particular areas of the brain classified by their cause. The neural damage they cause are of growing concern as the number of young adults experiencing strokes has increased by 11% in the last decade. Following stroke, there is an imbalance of inhibitory and excitatory neuronal activity, and disruption of neural networks. These changes lead to neuronal death and loss of synaptic connections that, depending on which part of the brain is affected, result in behavioral deficits such as weakness, limb hemiparesis, and loss of coordination, as well as speech and cognitive …

Adaptive Evaluation For Systems In Rapid Change Or Sustained Transition: Innovations And Applications Generated From A Community-Based Diabetes Prevention Program During The Covid-19 Pandemic, Amy Kuhn

CGU Theses & Dissertations

Program evaluation is a key part of the life cycle of public health and prevention science projects. But in complex environments or evolving situations, existing evaluation theory faces challenges in successful practical application. Process evaluation can track changes as a program runs, but when a program operates outside of its original design, questions can arise related to fidelity of implementation and interpretation of results. Outcome evaluation often requires a closed system without changes to determine actual effects of a program, but in times of complicated change that isolation can be difficult to achieve or to work around. In practice, systems …

Saftey Of Covid-19 Vaccines In Real World Studies, Khawla Amar Mohamed Gammudi

CGU Theses & Dissertations

Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been present since its outbreak in 2019. Despite global efforts to fully halt its spread, new strains are emerging daily. Various efforts have been undertaken to slow down the infection's spread by implementing different restrictive measures and policies, such as lockdowns, social distancing, and mask-wearing. However, the most effective approach to controlling this disease is through vaccinations (Chen, 2021). Substantial efforts have been dedicated to encouraging people in the United States to receive COVID-19 vaccines and booster doses. As of December 7, 2022, approximately 68.5% of the world's …

Utilizing Translational Research To Identify And Develop Effective Strategies For Operationalizing And Implementing A National Board Health And Wellness Coaching (Nbhwc) Certification Program Within The Non-Profit, Living Your Truth Empowered (Lyte), Rielly Keyser

CGU Theses & Dissertations

Introduction: This dissertation presents a comprehensive study that employs a combined formative and translational research design, alongside a mixed methods approach, to identify and develop strategies for operationalizing and implementing a National Board of Health and Wellness Coaching (NBHWC) certification program within the nonprofit organization Living Your Truth Empowered (LYTE). The research involves evidence-based strategies identification, analysis, and strategic planning to enhance the program's launch and effectiveness, with a particular focus on serving the diverse breast cancer community.

Methods: The study begins with an extensive literature review and the examination of 32 similar programs to identify OPR and IMP strategies. …

Mental Health Stigma In South Asians With Crohn’S Disease, Bansi Patel

Scripps Senior Theses

Chronically ill individuals often face comorbid mental illnesses. Mental illness symptoms can cause their chronic illness symptoms to worsen; the converse is also true. Such is the case with Crohn’s disease (CD) patients. The present literature lacks research on the relationship between CD and mental illness symptoms. Additionally, the literature lacks chronically ill participants who are South Asian Americans (SAA). SAA often face more mental health stigma than their white peers which can worsen one’s mental illness symptoms. This study examines the impact that mental health symptoms have on the psychological distress faced by SAA who are diagnosed with CD. …

Efficacy Of Adapted Mindfulness-Based Stress Reduction Program In Treating Patients With Mild Traumatic Brain Injury, Kate Whipple

Scripps Senior Theses

Mindfulness-based stress reduction (MBSR) has been applied in many contexts, and has been found to be a helpful therapeutic intervention for people dealing with both mental and physical struggles. In recent years, studies exploring the effects of using MBSR in the neurorehabilitation people with traumatic brain injuries (TBIs) have emerged. However, these studies are primarily pilot studies with very few participants. This proposed study will explore whether an adapted version of the MBSR program is effective in reducing apathy and improving motivation to recover in participants with mild TBIs (mTBIs). The proposed study will have 76 participants and will uses …

We Can Do This / Juntos Sí Podemos: A Critical Discourse Analysis Of Government-Sponsored Covid-19 Public Service Announcements (Psas) In English And Spanish, Katalina R. Peterson

Scripps Senior Theses

Communication inequities are known to negatively impact people from socioeconomically and linguistically disadvantaged backgrounds during public health crises (Gomez-Aguinaga et al., 2021). In the United States, Hispanics—especially those who speak Spanish—have been among the communities most disproportionately affected by COVID-19 (National Center for Health Statistics, 2022). The pandemic has underscored the importance of understanding the linguistic and discursive strategies implemented by institutions entrusted with disseminating public health information to reach diverse audiences, especially the most vulnerable. This paper analyzes the linguistic practices used to create public service announcements (PSA) produced in English and Spanish by health agencies at both the …

Seed Storytelling: Growing Food As Cultural And Ecological Resilience In Asian American Communities, Kaitlyn Chin

Scripps Senior Theses

For many communities in the Asian American diaspora impacted by colonial legacies of the U.S., there is an understanding that healing and wellness are practiced on the community level. Practices of collective care have been found through growing and sharing nourishing food and plants, which have the ability to ground communities in their sense of home and family. This project looks historically at Asian American relationships to settler colonialism and agricultural labor, and then turns to how small-scale Asian American farmers and Asian immigrant gardeners are practicing community-based care by saving and stewarding seed varieties that are meaningful in their …

The Role Of Herbal Medicines In Central American Indigenous Communities; Improving Accessibility To Type 2 Diabetes Mellitus Treatment, Sarai Ortega

CMC Senior Theses

Indigenous communities in Central America have used various plant medications to treat illnesses and diseases for centuries. Clinicians must consider improving traditional healthcare methods that are intrinsic to indigenous communities in order to increase access to effective treatments, particularly for diseases that these communities are more at risk for. This work aims to propose a method to identify whether traditional preparations of five plants (Anacardium occidentale L., Hamelia patens Jacq., Momordica charantia L, Neurolaena lobota L. R. Br. Ex Cass., and Tecoma stans L. juss. ex Kunth) can reduce blood glucose levels in rats with type two diabetes. Additionally, …

Pict-Dpa: A Quality-Compliance Data Processing Architecture To Improve The Performance Of Integrated Emergency Care Clinical Decision Support System, Ruizhi Yu

CGU Theses & Dissertations

Emergency Care System (ECS) is a critical component of health care systems by providing acute resuscitation and life-saving care. As a time-sensitive care operation system, any delay and mistake in the decision-making of these EC functions can create additional risks of adverse events and clinical incidents. The Emergency Care Clinical Decision Support System (EC-CDSS) has proven to improve the quality of the aforementioned EC functions. However, the literature is scarce on how to implement and evaluate the EC-CDSS with regard to the improvement of PHOs, which is the ultimate goal of ECS. The reasons are twofold: 1) lack of clear …

The Impact Of Sugar Sweetened Beverages (Ssbs) Taxes On Consumption And Health Outcomes In Latinx Youth Residing In Los Angeles County, Jacquelyn Campos-Araujo

Pitzer Senior Theses

This proposed research study aims to investigate whether the implementation of sugar-sweetened beverage (SSB) taxes will lead to reduced consumption and improved health outcomes in the Latinx youth population residing in Los Angeles County. The study will utilize a mixed-methods design, including a baseline survey and health examination, the implementation of SSB taxes, and a follow-up survey and health examination. The expected results suggest a statistically significant reduction in SSB consumption and improved glycemic control following the implementation of the SSB taxation intervention. However, I predict a slight decrease in the number of participants with dental caries, indicating that further …

A Systems-Based Patient Aid Design Artifact For Active Medication Management In Type 2 Diabetes, Ibrahim A. Hamzah

CGU Theses & Dissertations

In this dissertation, I explore the use of the Abstraction-Decomposition Space (ADS) alongside Hierarchical Task Analysis (HTA) to guide the design of a minimalist patient aid for active medication management in type 2 diabetes. The goal is to address a practical problem, but in addition, this study seeks to address a theoretical problem that is prevalent in design research in Information Systems (IS) today. The practical problem concerns the need for IT-based care delivery models to support patients in the interim period between in-person visits. In this vein, I present a bare-minimum design that focuses on the most essential functionality …

Analysis Of Biologically Effective Dose For Retroactive Yttrium-90 Trans-Arterial Radioembolization Treatment Optimization, Mj Lindsey

CMC Senior Theses

Trans-arterial radioembolization (TARE) is a protracted modality of radiation therapy where radionuclides labeled with Yttrium-90 (⁹⁰Y) are inserted inside a patient's hepatic artery to treat hepatocellular carcinoma (HCC). While TARE has been shown to be a clinically effective and safe treatment, there is little understanding of the radiobiological relationship between absorbed dose and tissue response, and thus there is no dosimetric standard for treatment planning. The Biologically Effective Dose (BED) formalism, derived from the Linear-Quadratic model of radiobiology, is used to weigh the absorbed dose by the time pattern of delivery. BED is a virtual dose that can …

Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini

CMC Senior Theses

Dance/movement therapy (D/MT) is the psychotherapeutic use of expressive, creative movement to support holistic well-being. D/MT views the human being as a single body-mind unit and movement as a manifestation of life experiences. While typically practiced as a mental health intervention, D/MT can be adapted for a variety of populations. This thesis evaluates scientific data for the non-traditional use of D/MT for three conditions: autism, Parkinson’s disease, and cancer. For individuals on the autism spectrum, D/MT can strengthen attunement skills, provide creative communication outlets, and relieve harmful physical manifestations of autism. For individuals with Parkinson’s disease, D/MT can simultaneously ease …