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Characteristics Of Patients Experiencing Extrapyramidal Symptoms Or Other Movement Disorders Related To Dopamine Receptor Blocking Agent Therapy, Shaina Musco, Laura Ruekert, Jaclyn Myers, Dennis Anderson, Michael Welling, Elizabeth Ann Cunningham

Scholarship and Professional Work – COPHS

Purpose/background: Dopamine receptor blocking agents (DRBAs), also known as antipsychotics, are medications widely used to treat a growing number of mental health diagnoses. However, their utility is limited by the potential to cause serious adverse movement reactions. Akathisia, dystonia, parkinsonism, and tardive dyskinesia (collectively known as extrapyramidal symptoms or EPSs) are associated with reduced social and occupational functioning, negative patient attitudes toward treatment, and nonadherence to pharmacotherapy. Neuroleptic malignant syndrome is a life-threatening reaction that can result from DRBA use and cause musculoskeletal dysfunction. The aim of this study is to profile patients who have developed DRBA-related movement adverse effects …