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Full-Text Articles in Medicine and Health Sciences
Antiurolithic Activity Of Origanum Vulgare Is Mediated Through Multiple Pathways, Aslam Khan, Samra Bashir, Saeed R. Khan, Anwar H. Gilani
Antiurolithic Activity Of Origanum Vulgare Is Mediated Through Multiple Pathways, Aslam Khan, Samra Bashir, Saeed R. Khan, Anwar H. Gilani
Department of Biological & Biomedical Sciences
Background: Origanum vulgare Linn has traditionally been used in the treatment of urolithiasis. Therefore, we investigated the crude extract of Origanum vulgare for possible antiurolithic effect, to rationalize its medicinal use. Methods: The crude aqueous-methanolic extract of Origanum vulgare (Ov.Cr) was studied using the in vitro and in vivo methods. In the in vitro experiments, supersaturated solution of calcium and oxalate, kidney epithelial cell lines (MDCK) and urinary bladder of rabbits were used, whereas, in the in vivo studies, rat model of urolithiasis was used for the study of preventive and curative effect. Results: In the in vitro experiments, Ov.Cr …
Studies On Buddleja Asiatica Antibacterial, Antifungal, Antispasmodic And Ca++ Antagonist Activities, Farman Ali, Irshad Ali, Hidayat Ullah Khan, Arif -Ullah Khan, Anwar Hassan Gilani
Studies On Buddleja Asiatica Antibacterial, Antifungal, Antispasmodic And Ca++ Antagonist Activities, Farman Ali, Irshad Ali, Hidayat Ullah Khan, Arif -Ullah Khan, Anwar Hassan Gilani
Department of Biological & Biomedical Sciences
Crude extract of Buddleja asiatica Lour and its fractions, chloroform (F1), ethyl acetate (F2) and nbutanol (F3) were evaluated for antibacterial, antifungal, antispasmodic and Ca++ antagonist activities. The antibacterial activity was performed against 11 types of bacteria. The crude extract and fractions F2 and F3 exhibited significant activity, while F1 showed low activity in killing the Shigella flexenari, Sternostoma boydi and Escherichia coli. In the rest bacteria, the crude extract and all the fractions (F1 to F3) revealed minimum to nil inhibitory effect. The fungicidal activity of the crude extract and all the fractions (F1 to F3) was also performed …
Antispasmodic And Ca++ Antagonist Potential Of Marrubiin, A Labdane Type Diterpene From Phlomis Bracteosa, Javid Hussain, Riaz Ullah, Arif-Ullah Khan, Fazal Mabood, Mohammad Raza Shah, Ahmed Al-Harrasi, Anwar Gilani
Antispasmodic And Ca++ Antagonist Potential Of Marrubiin, A Labdane Type Diterpene From Phlomis Bracteosa, Javid Hussain, Riaz Ullah, Arif-Ullah Khan, Fazal Mabood, Mohammad Raza Shah, Ahmed Al-Harrasi, Anwar Gilani
Department of Biological & Biomedical Sciences
A tricyclic labdane type diterpene was isolated for the first time from ethyl acetate soluble part of Phlomis bracteosa. Its structure was confirmed by x-ray which was found to be marrubiin. When studied in isolated rabbit jejunum, marrubiin caused concentration-dependent relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that marrubiin exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action.
Albumin Precursorandhsp70modulatecornealwoundhealinginanorgan Culturemodel, Anwar Ali Siddiqui Aga Khan University, Shamim Mushtaq Shamim Mushtaq, Zulfiqaralinaqvi Zulfiqaralinaqvi, Nikhatahmed Nikhatahmed
Albumin Precursorandhsp70modulatecornealwoundhealinginanorgan Culturemodel, Anwar Ali Siddiqui Aga Khan University, Shamim Mushtaq Shamim Mushtaq, Zulfiqaralinaqvi Zulfiqaralinaqvi, Nikhatahmed Nikhatahmed
Department of Biological & Biomedical Sciences
In order to investigate the role of albumin precursor and Hsp70 in corneal wound healing, we have analyzed the distribution of these proteins in wounded and non-wounded corneas of rabbits and the effects of topical applications of anti-albumin precursor and anti-Hsp70 antibodies on wound healing. Anti-albumin precursor and anti-Hsp70 antibodies were topically applied in healing corneal epithelium of rabbit eyes in organ culture. Corneas were allowed to heal in vitro for up to 120 h in serum-free medium with 5 and 10 μg/ml or without (migrating control) anti-albumin precursor/ or anti-Hsp70 antibodies. Fibronectin (Fb) (5 μg/ml) was used as a …