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Full-Text Articles in Medicine and Health Sciences
Investigating The Link Between Aging-Related Vascular Dysfunction And Peripheral Neuropathy Through Pressure Myography, Bailey Woodard
Investigating The Link Between Aging-Related Vascular Dysfunction And Peripheral Neuropathy Through Pressure Myography, Bailey Woodard
Honors College
Peripheral neuropathy can be defined as any condition that reduces the innervation of peripheral tissues. Pathologies such as diabetes and aging are catalysts for the development of peripheral neuropathy starting in the skin. It is known that neuropathy with aging and obesity extends into adipose in the C57BL/6 mouse model.Losing proper nerve communication between brain and adipose tissue is detrimental to metabolic health because it reduces the capacity of adipose to undergo necessary processes such as browning and lipolysis. Additionally, it can also worsen obesity and diabetes. Since aging increases the risk for these pathologies, a better understanding of neuropathy …
Evaluating The Occurrence Of Age-Related Peripheral Neuropathy In Het3 Mice And Development Of A Whole Tissue Imaging Technique For Analyzing Total Innervation In The Subcutaneous Adipose Depot, Jake Willows
Electronic Theses and Dissertations
Adipose tissue can be characterized as either being a white (energy storing) depot or a brown (energy expending) depot and both have been found to contain dense networks of neural innervation. This adipose nerve supply regulates numerous metabolic functions and likely plays an important role in the function of adipose blood vessels. Recently our lab has shown in the C57BL/6 mouse model that peripheral neuropathy, or the dying back and dysfunction of the nerves in the superficial tissues such as the skin, can extend into the subcutaneous adipose tissue in conditions commonly associated with the neuropathic phenotype (i.e. diabetes, obesity, …