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Full-Text Articles in Medicine and Health Sciences
Evaluating Forensic Dna Evidence - A Day-Long Workshop, Dan E. Krane, William C. Thompson
Evaluating Forensic Dna Evidence - A Day-Long Workshop, Dan E. Krane, William C. Thompson
Biological Sciences Faculty Publications
No abstract provided.
Keeping Insects At Bay: Beyond Deet, Thomas P. Rooney
Keeping Insects At Bay: Beyond Deet, Thomas P. Rooney
Biological Sciences Faculty Publications
No abstract provided.
Comparison Of C. Elegans And C. Briggsae Genome Sequences Reveals Extensive Conservation Of Chromosome Organization And Synteny, Ladeana W. Hiller, Raymond D. Miller, Scott Everet Baird, Asif Chinwalla, Lucinda A. Fulton, Daniel C. Koboldt, Robert H. Waterston
Comparison Of C. Elegans And C. Briggsae Genome Sequences Reveals Extensive Conservation Of Chromosome Organization And Synteny, Ladeana W. Hiller, Raymond D. Miller, Scott Everet Baird, Asif Chinwalla, Lucinda A. Fulton, Daniel C. Koboldt, Robert H. Waterston
Biological Sciences Faculty Publications
To determine whether the distinctive features of Caenorhabditis elegans chromosomal organization are shared with the C. briggsae genome, we constructed a single nucleotide polymorphism-based genetic map to order and orient the whole genome shotgun assembly along the six C. briggsae chromosomes. Although these species are of the same genus, their most recent common ancestor existed 80-110 million years ago, and thus they are more evolutionarily distant than, for example, human and mouse. We found that, like C. elegans chromosomes, C. briggsae chromosomes exhibit high levels of recombination on the arms along with higher repeat density, a higher fraction of intronic …
Essential Elements Of A Defense-Review Of Dna Testing Results, Dan E. Krane
Essential Elements Of A Defense-Review Of Dna Testing Results, Dan E. Krane
Biological Sciences Faculty Publications
No abstract provided.
Some Of The Problems Associated With Lcn (Low Copy Number) Testing, Dan E. Krane
Some Of The Problems Associated With Lcn (Low Copy Number) Testing, Dan E. Krane
Biological Sciences Faculty Publications
No abstract provided.
Run-Specific Limits Of Quantitation And Detection (An Alternative To Minimum Peak Height Thresholds), Dan E. Krane
Run-Specific Limits Of Quantitation And Detection (An Alternative To Minimum Peak Height Thresholds), Dan E. Krane
Biological Sciences Faculty Publications
No abstract provided.
Empirical Analysis Of The Str Profiles Resulting From Conceptual Mixtures, Dan E. Krane
Empirical Analysis Of The Str Profiles Resulting From Conceptual Mixtures, Dan E. Krane
Biological Sciences Faculty Publications
No abstract provided.
Assessing The Implications For Close Relatives In The Event Of Similar But Non-Matching Dna Profiles, Dan E. Krane
Assessing The Implications For Close Relatives In The Event Of Similar But Non-Matching Dna Profiles, Dan E. Krane
Biological Sciences Faculty Publications
No abstract provided.
Autoregulation Of Gld-2 Cytoplasmic Poly(A) Polymerase, Labib Rouhana, Marvin Wickens
Autoregulation Of Gld-2 Cytoplasmic Poly(A) Polymerase, Labib Rouhana, Marvin Wickens
Biological Sciences Faculty Publications
Cytoplasmic polyadenylation regulates mRNA stability and translation and is required for early development and synaptic plasticity. The GLD-2 poly(A) polymerase catalyzes cytoplasmic polyadenylation in the germline of metazoa. Among vertebrates, the enzyme is encoded by two isoforms of mRNA that differ only in the length of their 3′-UTRs. Here we focus on regulation of vertebrateGLD-2 mRNA. We show that the 3′-UTR of GLD-2 mRNA elicits its own polyadenylation and translational activation during frog oocyte maturation. We identify the sequence elements responsible for repression and activation, and demonstrate that CPEB and PUF proteins likely mediate repression in the resting oocyte. …
An Epidemiological Model Of Rift Valley Fever, Holly D. Gaff, David M. Hartley, Nicole P. Leahy
An Epidemiological Model Of Rift Valley Fever, Holly D. Gaff, David M. Hartley, Nicole P. Leahy
Biological Sciences Faculty Publications
We present and explore a novel mathematical model of the epidemiology of Rift Valley Fever (RVF). RVF is an Old World, mosquito-borne disease affecting both livestock and humans. The model is an ordinary differential equation model for two populations of mosquito species, those that can transmit vertically and those that cannot, and for one livestock population. We analyze the model to find the stability of the disease-free equlibrium and test which model parameters affect this stability most significantly. This model is the basis for future research into the predication of future outbreaks in the Old World and the assessment of …
Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, Michael Riscoe
Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, Michael Riscoe
Biological Sciences Faculty Publications
A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobolograrn analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive …