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Full-Text Articles in Medicine and Health Sciences
"What Should Happen Before Asymptomatic Men Decide Whether Or Not To Have A Psa Test?"A Report On Three Community Juries, Chris Degeling, Lucie Rychetnik, Kristen Pickles, Rae Thomas, Jennifer Doust, Robert Gardiner, Paul Glasziou, Ainsley Newson, Stacy Carter
"What Should Happen Before Asymptomatic Men Decide Whether Or Not To Have A Psa Test?"A Report On Three Community Juries, Chris Degeling, Lucie Rychetnik, Kristen Pickles, Rae Thomas, Jennifer Doust, Robert Gardiner, Paul Glasziou, Ainsley Newson, Stacy Carter
Jenny Doust
OBJECTIVES: To elicit the views of well informed community members on the ethical obligations of general practitioners regarding prostate-specific antigen (PSA) testing, and what should be required before a man undergoes a PSA test. DESIGN AND SETTING: Three community juries held at the University of Sydney over 6 months in 2014. PARTICIPANTS: Forty participants from New South Wales, of diverse social and cultural backgrounds and with no experience of prostate cancer, recruited through public advertising: two juries of mixed gender and ages; one all-male jury of PSA screening age. RESULTS: In contrast to Royal Australian College of General Practitioners guidelines, …
"What Should Happen Before Asymptomatic Men Decide Whether Or Not To Have A Psa Test?"A Report On Three Community Juries, Chris Degeling, Lucie Rychetnik, Kristen Pickles, Rae Thomas, Jennifer Doust, Robert Gardiner, Paul Glasziou, Ainsley Newson, Stacy Carter
"What Should Happen Before Asymptomatic Men Decide Whether Or Not To Have A Psa Test?"A Report On Three Community Juries, Chris Degeling, Lucie Rychetnik, Kristen Pickles, Rae Thomas, Jennifer Doust, Robert Gardiner, Paul Glasziou, Ainsley Newson, Stacy Carter
Rae Thomas
OBJECTIVES: To elicit the views of well informed community members on the ethical obligations of general practitioners regarding prostate-specific antigen (PSA) testing, and what should be required before a man undergoes a PSA test. DESIGN AND SETTING: Three community juries held at the University of Sydney over 6 months in 2014. PARTICIPANTS: Forty participants from New South Wales, of diverse social and cultural backgrounds and with no experience of prostate cancer, recruited through public advertising: two juries of mixed gender and ages; one all-male jury of PSA screening age. RESULTS: In contrast to Royal Australian College of General Practitioners guidelines, …
Predictors Of Depression In Prostate Cancer Patients: A Comparison Of Psychological Resilience Versus Pre-Existing Anxiety And Depression, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie
Predictors Of Depression In Prostate Cancer Patients: A Comparison Of Psychological Resilience Versus Pre-Existing Anxiety And Depression, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie
Vicki Bitsika
Background: Previous anxiety and depression can influence current anxiety and depression, and psychological resilience may be a buffer against current anxiety and depression. However, despite the relevance of these two sets of predictors of anxiety and depression, and their potential in treatment planning, no reports have been published on their role in post-diagnosis anxiety and depression among prostate cancer (PCa) patients. Therefore, this study aimed to determine the roles of these predictors in a sample of men with prostate cancer. Method: Retrospective self-reports of anxiety and depression for how they were before receiving their diagnosis of PCa and at the …
The Link Between Value Motives, Value Success, And Well-Being Among People Diagnosed With Cancer, Lisbeth Lane, Joseph Ciarrochi, Danielle Fisher
The Link Between Value Motives, Value Success, And Well-Being Among People Diagnosed With Cancer, Lisbeth Lane, Joseph Ciarrochi, Danielle Fisher
joseph Ciarrochi
Objective: This study investigated the relationship between cancer patientÿs values and cancerrelated distress.Method: A total of 107 patients with cancer diagnoses completed an anonymousquestionnaire.Results: Less self-regulating motivation for health values was significantly related to poorerwell-being. Greater success at living oneÿs values was significantly related to improved wellbeingand distress-related outcomes. Sex difference analysis suggested that success atfriendship values was linked to less cancer-related distress among women, but not men, whereassuccess at romantic relationship values was linked to less distress among men, but not women.Conclusion: The results have important implications for values focused interventions,highlighting the importance of facilitating success at valued living …
Paradoxical Effects Of The Autophagy Inhibitor 3-Methyladenine On Docetaxel-Induced Toxicity In Pc-3 And Lncap Prostate Cancer Cells, Rebecca Pickard, Briohny Spencer, Amelia Mcfarland, Nijole Bernaitis, Andrew Davey, Russ Chess-Williams, Catherine Mcdermott, Amanda Forbes, David Christie, Shailendra Anoopkumar-Dukie
Paradoxical Effects Of The Autophagy Inhibitor 3-Methyladenine On Docetaxel-Induced Toxicity In Pc-3 And Lncap Prostate Cancer Cells, Rebecca Pickard, Briohny Spencer, Amelia Mcfarland, Nijole Bernaitis, Andrew Davey, Russ Chess-Williams, Catherine Mcdermott, Amanda Forbes, David Christie, Shailendra Anoopkumar-Dukie
Russ Chess-Williams
Survival time in patients with androgen-resistant prostate cancer. However, it provides only a modest increase in survival and is associated with significant toxicity. Therefore, there is an urgent need to identify potential adjunct therapies. Given the key role of autophagy in both tumour survival and chemoresistance, the impact of autophagy modulation on docetaxel toxicity was tested in vitro. PC-3 and LNCaP cells were pre-treated with the autophagy inhibitor 3- methyladenine (5 mM) and then exposed to various concentrations (0–100 μM) of docetaxel. Cytoxic effects of docetaxel were measured using resazurin reduction to resorufin, whilst autophagy and apoptosis was measured using …
Paradoxical Effects Of The Autophagy Inhibitor 3-Methyladenine On Docetaxel-Induced Toxicity In Pc-3 And Lncap Prostate Cancer Cells, Rebecca Pickard, Briohny Spencer, Amelia Mcfarland, Nijole Bernaitis, Andrew Davey, Russ Chess-Williams, Catherine Mcdermott, Amanda Forbes, David Christie, Shailendra Anoopkumar-Dukie
Paradoxical Effects Of The Autophagy Inhibitor 3-Methyladenine On Docetaxel-Induced Toxicity In Pc-3 And Lncap Prostate Cancer Cells, Rebecca Pickard, Briohny Spencer, Amelia Mcfarland, Nijole Bernaitis, Andrew Davey, Russ Chess-Williams, Catherine Mcdermott, Amanda Forbes, David Christie, Shailendra Anoopkumar-Dukie
Catherine M. McDermott
Survival time in patients with androgen-resistant prostate cancer. However, it provides only a modest increase in survival and is associated with significant toxicity. Therefore, there is an urgent need to identify potential adjunct therapies. Given the key role of autophagy in both tumour survival and chemoresistance, the impact of autophagy modulation on docetaxel toxicity was tested in vitro. PC-3 and LNCaP cells were pre-treated with the autophagy inhibitor 3- methyladenine (5 mM) and then exposed to various concentrations (0–100 μM) of docetaxel. Cytoxic effects of docetaxel were measured using resazurin reduction to resorufin, whilst autophagy and apoptosis was measured using …
Enhanced Urothelial Atp Release And Contraction Following Intravesical Treatment With The Cytotoxic Drug, Doxorubicin, Stanley Kang, Catherine Mcdermott, Stef Farr, R. Chess-Williams
Enhanced Urothelial Atp Release And Contraction Following Intravesical Treatment With The Cytotoxic Drug, Doxorubicin, Stanley Kang, Catherine Mcdermott, Stef Farr, R. Chess-Williams
Catherine M. McDermott
Intravesical administration of the cytotoxic drug doxorubicin is a common treatment for superficial carcinoma of the bladder, but it is associated with significant urological adverse effects. The aim of this study was to identify doxorubicin-induced changes in the local mechanisms involved in regulating bladder function. As a model of intravesical doxorubicin administration in patients, doxorubicin (1 mg/mL) was applied to the luminal surface of porcine bladders for 60 min. Following treatment, the release of urothelial/lamina propria mediators (acetylcholine (Ach), ATP and prostaglandin E2 (PGE2) and contractile responses of isolated tissue strips was investigated. Doxorubicin pretreatment did not affect contractile responses …
Induction Of Inflammatory Cytokines And Alteration Of Urothelial Atp, Acetylcholine And Prostaglandin E2 Release By Doxorubicin, Sung-Hung Kang, Russ Chess-Williams, Shailendra Anoopkumar-Dukie, Catherine Mcdermott
Induction Of Inflammatory Cytokines And Alteration Of Urothelial Atp, Acetylcholine And Prostaglandin E2 Release By Doxorubicin, Sung-Hung Kang, Russ Chess-Williams, Shailendra Anoopkumar-Dukie, Catherine Mcdermott
Catherine M. McDermott
Intravesical treatment with cytotoxic drugs such as doxorubicin is associated with local adverse effects in bladder cancer patients. Here we investigate the effects of doxorubicin on urothelial release of ATP, acetylcholine and prostaglandin E2, and production of inflammatory cytokines. Urothelial cells were treated with doxorubicin for 1 h at 37 °C. Immediately or 24 h following treatment the level of ATP, acetylcholine and prostaglandin E2 released under basal and stimulated conditions was measured and compared to release from vehicle treated control cultures. The presence of inflammatory cytokines, in culture medium was also assessed 24 h after doxorubicin pre-treatment. Immediately following …
Induction Of Inflammatory Cytokines And Alteration Of Urothelial Atp, Acetylcholine And Prostaglandin E2 Release By Doxorubicin, Sung-Hung Kang, Russ Chess-Williams, Shailendra Anoopkumar-Dukie, Catherine Mcdermott
Induction Of Inflammatory Cytokines And Alteration Of Urothelial Atp, Acetylcholine And Prostaglandin E2 Release By Doxorubicin, Sung-Hung Kang, Russ Chess-Williams, Shailendra Anoopkumar-Dukie, Catherine Mcdermott
Russ Chess-Williams
Intravesical treatment with cytotoxic drugs such as doxorubicin is associated with local adverse effects in bladder cancer patients. Here we investigate the effects of doxorubicin on urothelial release of ATP, acetylcholine and prostaglandin E2, and production of inflammatory cytokines. Urothelial cells were treated with doxorubicin for 1 h at 37 °C. Immediately or 24 h following treatment the level of ATP, acetylcholine and prostaglandin E2 released under basal and stimulated conditions was measured and compared to release from vehicle treated control cultures. The presence of inflammatory cytokines, in culture medium was also assessed 24 h after doxorubicin pre-treatment. Immediately following …
Preliminary Investigations Into Triazole Derived Androgen Receptor Antagonists, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson
Preliminary Investigations Into Triazole Derived Androgen Receptor Antagonists, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson
Anna Lohning
A range of 1,4-substituted-1,2,3-N-phenyltriazoles were synthesized and evaluated as non-steroidal androgen receptor (AR) antagonists. The motivation for this study was to replace the N-phenyl amide portion of small molecule antiandrogens with a 1,2,3-triazole and determine effects, if any, on biological activity. The synthetic methodology presented herein is robust, high yielding and extremely rapid. Using this methodology a series of 17 N-aryl triazoles were synthesized from commercially available starting materials in less than 3 h. After preliminary biological screening at 20 and 40 lM, the most promising three compounds were found to display IC50 values of 40–50 lM against androgen dependent …