Medicine and Health Sciences Commons^™

Social Motivation Is Associated With Elevated Salivary Cortisol In Boys With An Asd, Vicki Bitsika, Christopher Sharpley, Linda Agnew, Nicholas Andronicos

Vicki Bitsika

Because social communication difficulties and stress are common in children with an ASD, and because it has been hypothesised that the two are related, the association between these two variables was investigated in a sample of 90 boys with an ASD and who were aged between 6 years and 12 years of age. The Social Responsiveness Scale (SRS) was completed by the parents of these boys about their sons, plus salivary cortisol samples were collected from the boys. Results indicated that only one aspect of the boys' SRS was significantly correlated with cortisol—Social Motivation (SM). Factor analyses revealed two discrete …

Age-Related Differences In The Association Between Stereotypic Behaviour And Salivary Cortisol In Young Males With An Autism Spectrum Disorder, Vicki Bitsika, Christopher Sharpley, Linda Agnew, Nicholas Andronicos

Vicki Bitsika

To identify if age influenced the relationship between one of the central symptoms of Autism Spectrum Disorder (ASD) and physiological stress, the association between stereotypic behaviour (SB) and stress-related cortisol concentrations was examined in a sample of 150 young males with an ASD. Parent-rated SB was significantly correlated with cortisol concentrations for boys aged 6 years to 12 years but not for adolescents aged 13 years to 18 years. This age-related difference in this association was not a function of cortisol concentrations but was related to differences in SB across these two age groups. IQ did not have a significant …

Which Aspects Of Sensory Features Are Associated With Elevated Cortisol Concentrations In Boys With An Autism Spectrum Disorder?, Vicki Bitsika, Christopher Sharpley, Nicholas Andronicos, Linda Agnew, Richard Mills

Vicki Bitsika

Difficulties in Sensory Features (SF) have been included in the most recent diagnostic processes for Autism Spectrum Disorder (ASD) and are more common in children with an ASD than their non-ASD peers. In addition, these difficulties with SF have been suggested as causing elevated stress and concentrations of salivary cortisol in young people with an ASD. However, previous studies have not examined the specific aspects of SF that are associated with elevated cortisol and that was the focus of this study with 135 boys with an ASD aged 6–18 years. The boys’ mothers assessed their sons’ SF with the Sensory …

Differences In The Prevalence, Severity And Symptom Profiles Of Depression In Boys And Adolescents With An Autism Spectrum Disorder Versus Normally Developing Controls, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

The prevalence, severity and symptom profiles for major depressive disorder (MDD) were compared in samples of boys and adolescents with and without an autism spectrum disorder (ASD). Self-reports were obtained on the Depression subscale of the Child and Adolescent Symptoms Inventory (CASI-D) with 70 ASD and 50 non-ASD male participants between the ages of 8 and 18 from Queensland, Australia who were matched for age and IQ. Results indicated that the ASD participants had significantly higher total CASI-D scores, a greater proportion of participants who qualified for a diagnosis of MDD, and over 50% higher scores for 8 of the …

Eight-Month Test-Retest Agreement In Morning Salivary Cortisol, Self- And Parent-Rated Anxiety In Boys With An Autism Spectrum Disorder, Christopher Sharpley, Vicki Bitsika, Linda Agnew, Nicholas Andronicos

Vicki Bitsika

The agreement over time in morning salivary cortisol concentrations and also self- and parent-rated anxiety was investigated in a sample of 16 boys with an ASD. Cortisol and anxiety data were collected eight months apart. Results indicated that there were significant correlations between each pair of measures from the two occasions, suggesting that cortisol concentrations and anxiety did not vary much at all over that time, challenging the assumption that cortisol needs to be measured over multiple days to obtain reliable data from children with an ASD. Implications for research into the ways these children respond to chronic stressors are …

Frontal Alpha Asymmetry As A Pathway To Behavioural Withdrawal In Depression: Research Findings And Issues, Emmanuel Jesulola, Christopher Sharpley, Vicki Bitsika, Linda Agnew, Peter Wilson

Vicki Bitsika

Depression has been described as a process of behavioural withdrawal from overwhelming aversive stressors, and which manifests itself in the diagnostic symptomatology for Major Depressive Disorder (MDD). The underlying neurobiological pathways to that behavioural withdrawal are suggested to include greater activation in the right vs the left frontal lobes, described as frontal EEG asymmetry. However, despite a previous meta-analysis that provided overall support for this EEG asymmetry hypothesis, inconsistencies and several methodological confounds exist. The current review examines the literature on this issue, identifies inconsistencies in findings and discusses several key research issues that require addressing for this field to …

Measuring Individual Burden Of Illness For Depression Among Prostate Cancer Patients, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Objective: This study aims to develop and test three potential models of Individual Burden of Illness for Depression (IBI-D) in prostate cancer patients. Methods: Responses to three sets of scales measuring depressive symptoms, functional impairment, and quality of life satisfaction were collected from 191 prostate cancer patients and analysed via principal components analysis to obtain weightings for each of the scales within the three sets of measures. These weightings were then used to form IBI-D Indices, and these were then compared with depressive symptoms alone for their overlap. Results: Single-factor solutions were found for each of the three IBI-D models, …

The Influence Of Gender, Age, Psychological Resilience And Family Interaction Factors Upon Anxiety And Depression In Non-Autism Spectrum Disorder Siblings Of Children With An Autism Spectrum Disorder, Vicki Bitsika, Christopher Sharpley, Rebecca Mailli

Vicki Bitsika

The influence of gender, age, Psychological resilience and family interaction factors upon generalised anxiety disorder (GAD) and major depressive disorder (MDD) was investigated in 75 non-autism spectrum disorder (NASD) siblings who had a brother or sister with an autism spectrum disorder (ASD). GAD and MDD were much more prevalent than in comparable age group samples, and adolescent females had the highest MDD rates. Several Psychological resilience skills were significantly associated with lower GAD and MDD, particularly being able to recognise mistakes in their thinking (for children) and being able to remain in control of their anger (for adolescents). Suggestions are …

Understanding, Experiences, And Reactions To Bullying Experiences In Boys With An Autism Spectrum Disorder, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

Most previous studies of bullying in young people with an Autism Spectrum Disorder (ASD) have relied on data from adults’ rather than the person with an ASD themselves, thus limiting our understanding of the bullying experience from the child’s perspective. To investigate this issue, 48 high-functioning boys with an ASD, and their mothers, completed an online questionnaire about various aspects of bullying. There were some minor discrepancies between mothers’ and their sons’ reported frequency of bullying. Boys demonstrated an understanding of the behaviour that constitutes bullying that was consistent with the wider literature, enhancing the validity of their responses about …

The Hot Flush Beliefs And Behaviour Scale For Men (Hfbbs-Men) Undergoing Treatment For Prostate Cancer, Myra Hunter, Christopher Sharpley, Evgenia Stefanopoulou, Omar Yousaf, Vicki Bitsika, David Christie

Vicki Bitsika

Objective: Hot flushes and night sweats (HFNS) are commonly experienced by men receiving treatment for prostate cancer. Cognitive behavioural therapy (CBT) has been found to be an effective treatment for HFNS in women, but cognitions and behavioural reactions to HFNS in men are under-researched. This study describes the development of the HFNS beliefs and behaviour scale for men.

Methods: HFNS beliefs and behaviour items were generated from a qualitative study, from pilot interviews with men with prostate cancer and HFNS, and from scales used for women. 118 men with prostate cancer, aged above 18, English-speaking, who had minimum of seven …

Variability In Depressive Symptoms Of Cognitive Deficit And Cognitive Bias During The First 2 Years After Diagnosis In Australian Men With Prostate Cancer, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly …

Differences In Major Depressive Disorder And Generalised Anxiety Disorder Symptomatology Between Prostate Cancer Patients Receiving Hormone Therapy And Those Who Are Not, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie

Vicki Bitsika

Objective: The aim of this study is to explore the associations between hormone treatment variables and depression, and the nature of depression in prostate cancer (PCa) patients by comparing the severity and symptom profile of anxiety and depression in men who were currently receiving hormone therapy (HT) versus those who were not. Method: Self-reports of anxiety and depression on standardized scales of GAD and major depressive disorder (MDD) were collected from 156 PCa patients across two recruitment sites in Australia. Patients who were currently receiving HT were compared with patients not receiving HT for their severity and symptom profiles on …

Variation In The Profile Of Anxiety Disorders In Boys With An Asd According To Method And Source Of Assessment, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

To determine any variation that might occur due to the type of assessment and source used to assess them, the prevalence of 7 anxiety disorders were investigated in a sample of 140 boys with an Autism spectrum disorder (ASD) and 50 non-ASD (NASD) boys via the Child and Adolescent Symptom Inventory and the KIDSCID Clinical Interview. Boys with an ASD were significantly more anxious than their NASD peers. Data collected from the boys with an ASD themselves showed differences in the severity and diagnostic criterion of anxiety disorders to data collected from the boys’ parents. There were age-related variations to …

Predictors Of Depression In Prostate Cancer Patients: A Comparison Of Psychological Resilience Versus Pre-Existing Anxiety And Depression, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie

Vicki Bitsika

Background: Previous anxiety and depression can influence current anxiety and depression, and psychological resilience may be a buffer against current anxiety and depression. However, despite the relevance of these two sets of predictors of anxiety and depression, and their potential in treatment planning, no reports have been published on their role in post-diagnosis anxiety and depression among prostate cancer (PCa) patients. Therefore, this study aimed to determine the roles of these predictors in a sample of men with prostate cancer. Method: Retrospective self-reports of anxiety and depression for how they were before receiving their diagnosis of PCa and at the …