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Should A Lower Treatment Line Be Used When Treating Paracetamol Poisoning In Patients With Chronic Alcoholism? A Case Against, Paul Dargan, Alison Jones
Should A Lower Treatment Line Be Used When Treating Paracetamol Poisoning In Patients With Chronic Alcoholism? A Case Against, Paul Dargan, Alison Jones
Alison L Jones
The widespread practice of using a lower plasma paracetamol (acetaminophen) concentration threshold for the treatment of paracetamol poisoning in patients with chronic alcoholism has been introduced on the basis of anecdotal case reports. In animals, acute alcohol loading inhibits toxic metabolic activation of paracetamol whilst chronic alcohol administration results in cytochrome P450 (CYP) 2E1 induction with increased toxic metabolic activation of paracetamol by CYP2E1 and increased hepatotoxicity. However, due to species differences in CYP expression, activity and induction, it is not possible extrapolate the results of these animal studies to clinical situations in humans. Isoenzymes are also responsible for the …
Complications Of Chronic Alcoholism That Affect Critical Illness, Alison Jones
Complications Of Chronic Alcoholism That Affect Critical Illness, Alison Jones
Alison L Jones
The worldwide consumption of alcohol is increasing. For uniformity, the consumption of alcohol often is expressed in terms of units of ethanol ingested. Table 14-1 shows how units of alcohol routinely are calculated. Not everyone who abuses alcohol develops liver damage, however. It is estimated that at least 80% of heavy drinkers show some features of fatty liver, 10% to 35% develop alcoholic hepatitis, and 10% develop cirrhosis. A retrospective study in men showed that 50% of men with an average intake of alcohol of greater than 160 g (15 to 16 units) per day for 20 years developed cirrhosis. …
Family Options For Parents With Mental Illnesses: A Developmental, Mixed Methods Pilot Study, Joanne Nicholson, Karen Albert, Bernice Gershenson, Valerie Williams, Kathleen Biebel
Family Options For Parents With Mental Illnesses: A Developmental, Mixed Methods Pilot Study, Joanne Nicholson, Karen Albert, Bernice Gershenson, Valerie Williams, Kathleen Biebel
Joanne Nicholson
OBJECTIVE: The objective of this paper is to provide a description of Family Options, a rehabilitation intervention for parents with serious mental illnesses and their children focusing on recovery and resilience, and to report the findings from a pilot study at 6-months post-enrollment for participating mothers. METHODS: A developmental design, and mixed quantitative and qualitative methods facilitate an in-depth understanding of Family Options and its impact on parents early in the implementation process. RESULTS: Participating families faced significant challenges, including long-term mental health conditions in adults, and emotional and behavioral difficulties in children. Data from mothers (n = 22) demonstrate …