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Articles 1 - 30 of 89
Full-Text Articles in Medicine and Health Sciences
Gender Differences In Cognitive Deficits In Schizophrenia With And Without Diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, Xu-Feng Huang
Gender Differences In Cognitive Deficits In Schizophrenia With And Without Diabetes, Bao Hua J. Zhang, Mei Han, Xiang Yang Zhang, Li Hui, Shu Rong Jiang, Fu-De Yang, Yun Long Tan, Zhi-Ren Wang, Juan Li, Xu-Feng Huang
Xu-Feng Huang
This study investigated gender differences in cognition in schizophrenia with and without diabetes. Cognition was assessed in 263 individuals with schizophrenia with age range (40-68): 67 males and 34 females with schizophrenia with diabetes; and 125 males and 37 females with schizophrenia without diabetes according to the repeatable battery for the assessment of neuropsychological status (RBANS). Fasting glucose, hemoglobin A1c (HbA1c) and lipid levels were measured. Results showed that male individuals performed worse on most cognitive tasks, especially attention, in schizophrenia with than without diabetes. This result was not observed in female individuals. Also, individuals of both genders showed higher …
Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu
Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu
Xu-Feng Huang
Purpose: Leptin inhibits feeding and increases energy expenditure through the central nervous system. High-fat diet with saturated fatty acids (SFA) or n-6 polyunsaturated fatty acids (n-6 PUFA) has been reported to induce central leptin resistance and obesity. However, little is known if central administration of SFA or n-6 PUFA can reduce central leptin sensitivity. This study examined the central leptin sensitivity in response to intracerebroventricular (i.c.v.) injection of SFA, palmitic acid (PA) and n-6 PUFA, arachidonic acid (ARA) in mice. Methods: After overnight fasting, C57BL/6J male mice (n=24/group) were i.c.v. injected with either PA (50pmol/2ul), ARA (50pmol/2ul) or vehicle (saline, …
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Xu-Feng Huang
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) …
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
Xu-Feng Huang
The neuregulin 1 gene has repeatedly been identified as a susceptibility gene for schizophrenia, thus mice with genetic mutations in this gene offer a valuable tool for studying the role of neuregulin 1 in schizophrenia-related neurotransmission. In this study, slide-based receptor autoradiography was used to quantify glutamatergic N-methyl-d-aspartate (NMDA), dopaminergic D2, cannabinoid CB1 and acetylcholine M1/4 receptor levels in the brains of male heterozygous transmembrane domain neuregulin 1 mutant (Nrg1+/−) mice at two ages. Mutant mice expressed small but significant increases in NMDA receptor levels in the cingulate cortex (7%, p = 0.044), sensory cortex (8%, p = 0.024), and …
Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Xu-Feng Huang
Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models of both drug-naïve …
Altered Il-2, Il-6 And Il-8 Serum Levels In Schizophrenia Patients With Tardive Dyskinesia, Hui-Mei An, Yun Long Tan, Jing Shi, Zhi-Ren Wang, Jair C. Soars, Jing Qin Wu, Fu-De Yang, Xu-Feng Huang, Xiang Yang Zhang
Altered Il-2, Il-6 And Il-8 Serum Levels In Schizophrenia Patients With Tardive Dyskinesia, Hui-Mei An, Yun Long Tan, Jing Shi, Zhi-Ren Wang, Jair C. Soars, Jing Qin Wu, Fu-De Yang, Xu-Feng Huang, Xiang Yang Zhang
Xu-Feng Huang
Immune deregulation has been postulated to be one of the mechanisms underlying the pathogenesis of tardive dyskinesia (TD). We hypothesized that interleukins would have a link with TD in schizophrenia patients. In this study, the serum IL-2, IL-6 and IL-8 levels were examined by enzyme-linked immunosorbent assay (ELISA) in schizophrenia patients with TD (n = 48) and without TD (n = 45), and healthy controls (n = 44). The psychopathological symptoms of schizophrenia were assessed by the Positive and Negative Syndrome Scale (PANSS). The severity of TD was evaluated using Abnormal Involuntary Movement Scale (AIMS). The results showed that serum …
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Xu-Feng Huang
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) …
Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Xu-Feng Huang
Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models of both drug-naïve …
An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell
An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell
Xu-Feng Huang
Purpose: Metabotropic glutamate receptors (mGluRs) are proposed novel therapeutic targets for a variety of brain disorders such as schizophrenia (SZ), bipolar disorder (BP) and major depression (MD). Despite their potential, the involvement of these receptors in these pathological processes is uncertain. This information is crucial to understand the efficiency of drugs that target these receptors. Methods: Using post-mortem human brains, mGluR2/3 and mGluR5 binding densities were measured in the anterior cingulate cortex of SZ, BP, MD and matched controls (CT) (n=15/group) by receptor autoradiography. Results: Whilst preliminary analyses indicated no diagnostic effect in mGluR2/3 or mGluR5 binding densities, mGluR2/3 binding …
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
Xu-Feng Huang
The neuregulin 1 gene has repeatedly been identified as a susceptibility gene for schizophrenia, thus mice with genetic mutations in this gene offer a valuable tool for studying the role of neuregulin 1 in schizophrenia-related neurotransmission. In this study, slide-based receptor autoradiography was used to quantify glutamatergic N-methyl-d-aspartate (NMDA), dopaminergic D2, cannabinoid CB1 and acetylcholine M1/4 receptor levels in the brains of male heterozygous transmembrane domain neuregulin 1 mutant (Nrg1+/−) mice at two ages. Mutant mice expressed small but significant increases in NMDA receptor levels in the cingulate cortex (7%, p = 0.044), sensory cortex (8%, p = 0.024), and …
Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Ameliorating Antipsychotic-Induced Weight Gain By Betahistine: Mechanisms And Clinical Implications, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Xu-Feng Huang
Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models of both drug-naïve …
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
Xu-Feng Huang
Description The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain currently available. The second edition of this classic book is a complete revision, featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will again be the indispensable resource for all scientists working on the primate nervous system. Key Features * 151 coronal diagrams and 151 accompanying photographic plates spaced at 120 um intervals; diagrams completely revised * 60 photographic coronal plates of SMI immunoreactivity; delineations completely revised. New in this edition * DVD …
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
Xu-Feng Huang
Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative …
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Xu-Feng Huang
An abstract of a poster presentation that presented at Australian Neuroscience Society 32nd Annual meeting.
Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell
Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
Xu-Feng Huang
From the Back Cover The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive, detailed atlas of the monkey brain ever constructed. The first chapter, "Photographic and Diagrammatic Atlas of the Rhesus Monkey Brain," presents 151 plates illustrating the subcortex and parts of the cortex in high magnification, and 151 corresponding diagrams complementing each image. The second chapter, "Delineation of the Rhesus Monkey Cortex on the Basis of the Distribution of a Neurofilament Protein," consists of 64 fully labeled plates depicting an entire hemisphere. Jointly, the two chapters constitute the most serious morphological work ever undertaken on the monkey. …
Mglur5 And Nmda Receptor Density Are Reduced In The Dorsolateral Prefrontal Cortex Of Schizoaffective But Not Schizophrenia Patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang
Mglur5 And Nmda Receptor Density Are Reduced In The Dorsolateral Prefrontal Cortex Of Schizoaffective But Not Schizophrenia Patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang
Xu-Feng Huang
Abstract of a poster that presented at the Society of Biological Psychiatry 67th Annual Meeting.
Are There Different Neural Mechanisms Responsible For Three Stages Of Weight Gain Development In Anti-Psychotic Therapy: Temporally Based Hypothesis, Nagesh Pai, Chao Deng, Shae-Leigh Vella, David Castle, Xu-Feng Huang
Are There Different Neural Mechanisms Responsible For Three Stages Of Weight Gain Development In Anti-Psychotic Therapy: Temporally Based Hypothesis, Nagesh Pai, Chao Deng, Shae-Leigh Vella, David Castle, Xu-Feng Huang
Xu-Feng Huang
Weight gain as a result of atypical anti-psychotic treatment is a common issue with different atypical anti-psychotic treatments causing differing magnitudes of weight gain. Although differing amounts of weight gain result from different atypical agents little is known about the temporal course of weight gain in anti- psychotic treatment. Specifically is the time course of weight gain comparable across different agents. Therefore this article reviews the temporal course of weight gain for three common atypical anti-psychotics namely; clozapine, olanzapine and risperidone. It is evident that all three of these agents exhibit similar although at distinct magnitudes temporal courses of weight …
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Xu-Feng Huang
The serotonergic system has close interactions with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate regional changes in 5-hydroxytryptamine (5-HT) 2A receptors in the rat brain 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). 5-HT 2A receptor distributions and alterations in the postmortem rat brain were detected by [3H]ketanserin-binding autoradiography. In the 6-OHDA-induced Parkinson’s rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [3H]ketanserin binding, predominantly in the agranular insular cortex (17.3%, P 5 0.03), cingulate cortex (18.2%, P < 0.001), prefrontal …
Activation Of Signal Pathways And The Resistance To Anti-Egfr Treatment In Colorectal Cancer, J-Z Chen, Xu-Feng Huang, Andrew Katsifis
Activation Of Signal Pathways And The Resistance To Anti-Egfr Treatment In Colorectal Cancer, J-Z Chen, Xu-Feng Huang, Andrew Katsifis
Xu-Feng Huang
No abstract provided.
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Developmental Vitamin D Deficiency Alters Mk-801-Induced Behaviours In Adult Offspring, James Kesby, Jonathan O'Loan, Suzanne Alexander, Chao Deng, Xu-Feng Huang, John Mcgrath, Darryl Eyles, Thomas Burne
Developmental Vitamin D Deficiency Alters Mk-801-Induced Behaviours In Adult Offspring, James Kesby, Jonathan O'Loan, Suzanne Alexander, Chao Deng, Xu-Feng Huang, John Mcgrath, Darryl Eyles, Thomas Burne
Xu-Feng Huang
Rationale Developmental vitamin D (DVD) deficiency is a candidate risk factor for developing schizophrenia in humans. In rodents DVD deficiency induces subtle changes in the way the brain develops. This early developmental insult leads to select behavioural changes in the adult, such as an enhanced response to amphetamine-induced locomotion in female DVD-deficient rats but not in male DVDdeficient rats and an enhanced locomotor response to the Nmethyl- D-aspartate (NMDA) receptor antagonist, MK-801, in male DVD-deficient rats. However, the response to MK- 801-induced locomotion in female DVD-deficient rats is unknown. Therefore, the aim of the current study was to further examine …
The Effects Of Antipsychotic Drugs Administration On 5-Ht1a Receptor Expression In The Limbic System Of The Rat Brain, Mei Han, Xu-Feng Huang, Teresa Du Bois, Chao Deng
The Effects Of Antipsychotic Drugs Administration On 5-Ht1a Receptor Expression In The Limbic System Of The Rat Brain, Mei Han, Xu-Feng Huang, Teresa Du Bois, Chao Deng
Xu-Feng Huang
Increasing evidence suggests that 5-HT1A receptors are involved in the pathophysiology and treatment of schizophrenia. This paper investigated 5-HT1A receptor mRNA expression and binding density in female rats treated with aripiprazole (2.25 mg/kg/day), olanzapine (1.5 mg/kg/day), haloperidol (0.3 mg/kg/day) or vehicle (control) orally three times/day for 1 or 12 weeks. Animals were sacrificed 48 h after the last administration. Aripiprazole significantly increased 5-HT1A receptor binding density by 33% in the CA1 region of the hippocampus and by 21% in the medial posterodorsal nuclei of posterior amygdala (MeP) compared to the control group after 1 week of treatment. Olanzapine significantly decreased …
Insulin Decreases Therapeutic Efficacy In Colon Cancer Cell Line Ht29 Via The Activation Of The Pi3k/Akt Pathway, J-Z Chen, Andrew Katsifis, Changhua Hu, Xu-Feng Huang
Insulin Decreases Therapeutic Efficacy In Colon Cancer Cell Line Ht29 Via The Activation Of The Pi3k/Akt Pathway, J-Z Chen, Andrew Katsifis, Changhua Hu, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.