Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 30 of 56

Full-Text Articles in Medicine and Health Sciences

The Sensitivity And Specificity Of A Simple Test To Distinguish Between Urge And Stress Urinary Incontinence., Jeanette Brown, Catherine Bradley, Leslee Subak, Holly Richter, Stephen Kraus, Linda Brubaker, Feng Lin, Eric Vittinghoff, Deborah Grady Apr 2013

The Sensitivity And Specificity Of A Simple Test To Distinguish Between Urge And Stress Urinary Incontinence., Jeanette Brown, Catherine Bradley, Leslee Subak, Holly Richter, Stephen Kraus, Linda Brubaker, Feng Lin, Eric Vittinghoff, Deborah Grady

Catherine S. Bradley

BACKGROUND: Urinary incontinence is common in women. Because treatments differ, urge incontinence should be distinguished from stress incontinence. To make this distinction, current guidelines recommend an extensive evaluation that is too time-consuming for primary care practice. OBJECTIVE: To test the accuracy of a simple questionnaire to categorize type of urinary incontinence in women. DESIGN: Multicenter, prospective study of the accuracy of the 3 Incontinence Questions (3IQ) compared with an extended evaluation to distinguish between urge incontinence and stress incontinence. SETTING: 5 academic medical centers in the United States. PARTICIPANTS: 301 women enrolled from April to December 2004 who were older …


Endometrial Adenocarcinoma With Trophoblastic Differentiation., Catherine Bradley, I. Benjamin, J. Wheeler, S. Rubin Apr 2013

Endometrial Adenocarcinoma With Trophoblastic Differentiation., Catherine Bradley, I. Benjamin, J. Wheeler, S. Rubin

Catherine S. Bradley

OBJECTIVE: To report a case of stage IIIc poorly differentiated endometrial adenocarcinoma with trophoblastic differentiation and to review previously reported cases. METHODS: The clinical course and histopathology of the case were reviewed, and a literature search for other reported cases was performed. RESULTS: The tumor contained syncytiotrophoblast-like giant cells that stained positively for the beta subunit of human chorionic gonadotropin (beta-hCG), and the patient's serum beta-hCG level was elevated (95 mIU/ml), but became undetectable after treatment. Beta-hCG was used as a tumor marker during further therapy. At 16 months' survival, she remains without evidence of disease and with a beta-hCG …


An Anatomic Reconstruction Of The Pelvic Floor And Perineum, Catherine Bradley, M. Beshara, J. Mikuta, M. Morgan Apr 2013

An Anatomic Reconstruction Of The Pelvic Floor And Perineum, Catherine Bradley, M. Beshara, J. Mikuta, M. Morgan

Catherine S. Bradley

No abstract provided.


Timing Of Postoperative Voiding Trial After Anti-Incontinence Procedures, J. Novi, S. Oloufa, J. Brannigan, B.H. Mulvihill, Catherine Bradley Apr 2013

Timing Of Postoperative Voiding Trial After Anti-Incontinence Procedures, J. Novi, S. Oloufa, J. Brannigan, B.H. Mulvihill, Catherine Bradley

Catherine S. Bradley

No abstract provided.


Pelvic Support, Pelvic Symptoms, And Patient Satisfaction After Colpocleisis., M. Fitzgerald, H. Richter, Catherine Bradley, W. Ye, A. Visco, G. Cundiff, H. Zyczynski, P. Fine, A. Weber Apr 2013

Pelvic Support, Pelvic Symptoms, And Patient Satisfaction After Colpocleisis., M. Fitzgerald, H. Richter, Catherine Bradley, W. Ye, A. Visco, G. Cundiff, H. Zyczynski, P. Fine, A. Weber

Catherine S. Bradley

The objective was to study the effect of colpocleisis on pelvic support, symptoms, and quality of life and report-associated morbidity and postoperative satisfaction. Women undergoing colpocleisis for treatment of pelvic organ prolapse (POP) were recruited at six centers. Baseline measures included physical examination, responses to the Pelvic Floor Distress Inventory, and Pelvic Floor Impact Questionnaire. Three and 12 months after surgery we repeated baseline measures. Of 152 patients with mean age 79 (+/-6) years, 132 (87%) completed 1 year follow-up. Three and 12 months after surgery, 90/110 (82%) and 75/103 (73%) patients following up had POP stage < or = 1. …


Pelvic Organ Prolapse In Older Women: Prevalence And Risk Factors., Ingrid Nygaard, Catherine Bradley, Debra Brandt Apr 2013

Pelvic Organ Prolapse In Older Women: Prevalence And Risk Factors., Ingrid Nygaard, Catherine Bradley, Debra Brandt

Catherine S. Bradley

OBJECTIVE: We sought to estimate the prevalence of pelvic organ prolapse in older women using the Pelvic Organ Prolapse Quantification examination and to identify factors associated with prolapse. METHODS: Women with a uterus enrolled at one site of the Women's Health Initiative Hormone Replacement Therapy randomized clinical trial were eligible for this ancillary cross-sectional study. Subjects underwent a Pelvic Organ Prolapse Quantification examination during a maximal Valsalva maneuver and in addition completed a questionnaire. Logistic regression was used to identify independent risk factors for each of 2 definitions of prolapse: 1) Pelvic Organ Prolapse Quantification stage II or greater and …


Development Of The Measure Of Adaptations For Pelvic Symptoms (Maps): The Importance Of Incorporating The Female Patient’S Voice, P. Wren, N. Janz, L. Brubaker, D. Borello-France, Catherine Bradley, K. Burgio, G. Cundiff, A. Weber, J. Wei Apr 2013

Development Of The Measure Of Adaptations For Pelvic Symptoms (Maps): The Importance Of Incorporating The Female Patient’S Voice, P. Wren, N. Janz, L. Brubaker, D. Borello-France, Catherine Bradley, K. Burgio, G. Cundiff, A. Weber, J. Wei

Catherine S. Bradley

No abstract provided.


Interstitial Cystitis: Evaluation And Management, Catherine Bradley, G. Singh Apr 2013

Interstitial Cystitis: Evaluation And Management, Catherine Bradley, G. Singh

Catherine S. Bradley

No abstract provided.


Pelvic Mass Presenting As An Irreducible Vaginal Vault Prolapse, Lily Arya, Joseph Novi, Alka Shaunik, Catherine Bradley Apr 2013

Pelvic Mass Presenting As An Irreducible Vaginal Vault Prolapse, Lily Arya, Joseph Novi, Alka Shaunik, Catherine Bradley

Catherine S. Bradley

A case report is presented of a patient with vaginal vault prolapse that could only be reduced under anesthesia with subsequent placement of a pessary. Spontaneous expulsion of the pessary and recurrence of the irreducible prolapse led to exploratory laparotomy revealing a large multiloculated cyst adherent to the vaginal cuff.


Pessaries And Devices: Non-Surgical Treatment Of Pelvic Organ Prolapse And Stress Urinary Incontinence, Catherine Bradley Apr 2013

Pessaries And Devices: Non-Surgical Treatment Of Pelvic Organ Prolapse And Stress Urinary Incontinence, Catherine Bradley

Catherine S. Bradley

No abstract provided.


Chapter 16: Pelvic Organ Prolapse, Catherine Bradley, L. Arya Apr 2013

Chapter 16: Pelvic Organ Prolapse, Catherine Bradley, L. Arya

Catherine S. Bradley

No abstract provided.


Chapter 17: Urinary Incontinence, L. Arya, Catherine Bradley Apr 2013

Chapter 17: Urinary Incontinence, L. Arya, Catherine Bradley

Catherine S. Bradley

No abstract provided.


Chapter 34: Disorders Of The Pelvic Floor, Catherine Bradley Apr 2013

Chapter 34: Disorders Of The Pelvic Floor, Catherine Bradley

Catherine S. Bradley

No abstract provided.


Case 50: Urinary Frequency And Urgency, Catherine Bradley Apr 2013

Case 50: Urinary Frequency And Urgency, Catherine Bradley

Catherine S. Bradley

No abstract provided.


Case 19: Abnormal Pap Smear, Catherine Bradley Apr 2013

Case 19: Abnormal Pap Smear, Catherine Bradley

Catherine S. Bradley

No abstract provided.


Chapter 83: Nonsurgical Treatments For Urinary Incontinence, Catherine Bradley, K. Whitmore Apr 2013

Chapter 83: Nonsurgical Treatments For Urinary Incontinence, Catherine Bradley, K. Whitmore

Catherine S. Bradley

No abstract provided.


A New Questionnaire For Urinary Incontinence Diagnosis In Women: Development And Testing, Catherine Bradley, E. Rovner, M. Morgan, M. Berlin, J. Novi, J. Shea, L. Arya Apr 2013

A New Questionnaire For Urinary Incontinence Diagnosis In Women: Development And Testing, Catherine Bradley, E. Rovner, M. Morgan, M. Berlin, J. Novi, J. Shea, L. Arya

Catherine S. Bradley

OBJECTIVE: The purpose of this study was to develop a questionnaire for urinary incontinence diagnosis in women and to test its reliability and validity, with incontinence specialists' clinical evaluations as the gold standard. STUDY DESIGN: One hundred seventeen urogynecology outpatients with urinary incontinence symptoms completed the Questionnaire for Urinary Incontinence Diagnosis at enrollment and 1 week and 9 months later. Baseline clinical diagnoses were compared with Questionnaire for Urinary Incontinence Diagnosis diagnoses (criterion validity). Nine-month Questionnaire for Urinary Incontinence Diagnosis change scores were compared across treatment groups (responsiveness). RESULTS: Clinical diagnoses included stress (n = 15), urge (n = 26), …


The Sensitivity And Specificity Of A Simple Test To Distinguish Between Urge And Stress Urinary Incontinence, J. S. Brown, Catherine Bradley, L. L. Subak, H. E. Richter, S. R. Kraus, L. Brubaker, F. Lin, E. Vittinghoff, D. Grady Apr 2013

The Sensitivity And Specificity Of A Simple Test To Distinguish Between Urge And Stress Urinary Incontinence, J. S. Brown, Catherine Bradley, L. L. Subak, H. E. Richter, S. R. Kraus, L. Brubaker, F. Lin, E. Vittinghoff, D. Grady

Catherine S. Bradley

BACKGROUND: Urinary incontinence is common in women. Because treatments differ, urge incontinence should be distinguished from stress incontinence. To make this distinction, current guidelines recommend an extensive evaluation that is too time-consuming for primary care practice. OBJECTIVE: To test the accuracy of a simple questionnaire to categorize type of urinary incontinence in women. DESIGN: Multicenter, prospective study of the accuracy of the 3 Incontinence Questions (3IQ) compared with an extended evaluation to distinguish between urge incontinence and stress incontinence. SETTING: 5 academic medical centers in the United States. PARTICIPANTS: 301 women enrolled from April to December 2004 who were older …


Magnetic Resonance Assessment Of Pelvic Anatomy And Pelvic Floor Disorders After Childbirth, V. Handa, M. Lockhart, K. Kenton, Catherine Bradley, J. Fielding, G. Cundiff, C. Salomon, C. Hakim, W. Ye, H. Richter Apr 2013

Magnetic Resonance Assessment Of Pelvic Anatomy And Pelvic Floor Disorders After Childbirth, V. Handa, M. Lockhart, K. Kenton, Catherine Bradley, J. Fielding, G. Cundiff, C. Salomon, C. Hakim, W. Ye, H. Richter

Catherine S. Bradley

To compare pelvic anatomy, using magnetic resonance imaging, between postpartum women with or without pelvic floor disorders. We measured postpartum bony and soft tissue pelvic dimensions in 246 primiparas, 6-12-months postpartum. Anatomy was compared between women with and without urinary or fecal incontinence, or pelvic organ prolapse; P < 0.01 was considered statistically significant. A deeper sacral hollow was significantly associated with fecal incontinence (P = 0.005). Urinary incontinence was marginally associated with a wider intertuberous diameter (P = 0.017) and pelvic arch (P = 0.017). There were no significant differences in pelvimetry measures between women with and without prolapse (e.g., vaginal or cervical descent to or beyond the hymen). We did not detect meaningful differences in soft tissue dimensions for women with and without these pelvic floor disorders. Dimensions of the bony pelvis do not differ substantially between primiparous women with and without postpartum urinary incontinence, fecal incontinence and prolapse.


Effects Of Colpocleisis On Bowel Symptoms Among Women With Severe Pelvic Organ Prolapse, R. Gutman, Catherine Bradley, W. Ye, A. Markland, W. Whitehead, M. Fitzgerald Apr 2013

Effects Of Colpocleisis On Bowel Symptoms Among Women With Severe Pelvic Organ Prolapse, R. Gutman, Catherine Bradley, W. Ye, A. Markland, W. Whitehead, M. Fitzgerald

Catherine S. Bradley

INTRODUCTION AND HYPOTHESIS: Our objective was to evaluate bowel symptoms after colpocleisis. METHODS: This was a planned ancillary analysis of a prospective, colpocleisis cohort study of 152 women. Those with baseline and 1-year questionnaires (Colorectal-Anal Distress Inventory (CRADI) and the Colorectal-Anal Impact Questionnaire (CRAIQ)) were included. "Bothersome" CRADI symptoms (score>2("moderately", "quite a bit")) were identified. CRADI and CRAIQ scores were compared, and postoperative symptom resolution and new symptom development were measured. RESULTS: Of 121 (80%) subjects with complete data, mean age was 79.2 +/- 5.4 years and all had stage 3-4 prolapse. Procedures performed: partial colpocleisis (61%), total colpocleisis …


Non-Surgical Management Of Stress Urinary Incontinence: Ambulatory Treatments For Leakage Associated With Stress (Atlas) Trial, H. Richter, K. Burgio, P. Goode, D. Borello-France, Catherine Bradley, L. Brubaker, V. Handa, P. Fine, A. Visco, H. Zyczynski, J. Wei, A. Weber Apr 2013

Non-Surgical Management Of Stress Urinary Incontinence: Ambulatory Treatments For Leakage Associated With Stress (Atlas) Trial, H. Richter, K. Burgio, P. Goode, D. Borello-France, Catherine Bradley, L. Brubaker, V. Handa, P. Fine, A. Visco, H. Zyczynski, J. Wei, A. Weber

Catherine S. Bradley

BACKGROUND: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. PURPOSE: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. METHODS: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient …


Vaginal Wall Descensus And Pelvic Floor Symptoms In Older Women, Catherine Bradley, I. Nygaard Apr 2013

Vaginal Wall Descensus And Pelvic Floor Symptoms In Older Women, Catherine Bradley, I. Nygaard

Catherine S. Bradley

OBJECTIVE: To understand the clinical significance of early pelvic organ prolapse in older women, we studied associations between vaginal descensus and pelvic floor symptoms. METHODS: In this cross-sectional study, 270 women enrolled at one site of the Women's Health Initiative clinical trial completed a questionnaire modified from the Pelvic Floor Distress Inventory on pelvic floor symptoms and underwent a Pelvic Organ Prolapse Quantification (POP-Q) examination. We tested associations between symptoms (individual and grouped) with anterior, posterior, uterine, and maximum vaginal descensus. RESULTS: Mean age was 68 years. Ninety-six percent had POP-Q stages I or II. Only obstructive urinary symptoms and …


The Questionnaire For Urinary Incontinence Diagnosis (Quid): Validity And Responsiveness To Change In Women Undergoing Non-Surgical Therapies For Treatment Of Stress Predominant Urinary Incontinence, Catherine Bradley, D. Rahn, I. Nygaard, M. Barber, C. Nager, K. Kenton, N. Siddiqui, R. Abel, C. Spino, H. Richter Apr 2013

The Questionnaire For Urinary Incontinence Diagnosis (Quid): Validity And Responsiveness To Change In Women Undergoing Non-Surgical Therapies For Treatment Of Stress Predominant Urinary Incontinence, Catherine Bradley, D. Rahn, I. Nygaard, M. Barber, C. Nager, K. Kenton, N. Siddiqui, R. Abel, C. Spino, H. Richter

Catherine S. Bradley

AIMS: The Questionnaire for Urinary Incontinence Diagnosis (QUID), a 6-item urinary incontinence (UI) symptom questionnaire, was developed and validated to distinguish stress and urge UI. This study's objective was to evaluate QUID validity and responsiveness when used as a clinical trial outcome measure. METHODS: Participants enrolled in a multi-center trial of non-surgical therapy (continence pessary, pelvic floor muscle training or combined) for stress-predominant UI and completed baseline and 3-month diaries, the Urinary Distress Inventory (UDI) and QUID. Data from all treatment groups were pooled. QUID internal consistency (Cronbach's alpha) and convergent/discriminant validity (Pearson correlations) were evaluated. Responsiveness to change was …


Urinary Incontinence Self-Report Questions: Reproducibility And Agreement With Bladder Diary, Catherine Bradley, J. Brown, S. Van Den Eeden, M. Schembri, A. Ragins, D. Thom Apr 2013

Urinary Incontinence Self-Report Questions: Reproducibility And Agreement With Bladder Diary, Catherine Bradley, J. Brown, S. Van Den Eeden, M. Schembri, A. Ragins, D. Thom

Catherine S. Bradley

INTRODUCTION AND HYPOTHESIS: This study aims to measure self-report urinary incontinence questions' reproducibility and agreement with bladder diary. METHODS: Data were analyzed from the Reproductive Risk of Incontinence Study at Kaiser. Participating women reporting at least weekly incontinence completed self-report incontinence questions and a 7-day bladder diary. Self-report question reproducibility was assessed and agreement between self-reported and diary-recorded voiding and incontinence frequency was measured. Test characteristics and area under the curve were calculated for self-reported incontinence types using diary as the gold standard. RESULTS: Five hundred ninety-one women were included and 425 completed a diary. The self-report questions had moderate …


Vaginal Erosion After Pubovaginal Sling Procedures Using Dermal Allografts, Catherine Bradley, M. Morgan, L. Arya, E. Rovner Apr 2013

Vaginal Erosion After Pubovaginal Sling Procedures Using Dermal Allografts, Catherine Bradley, M. Morgan, L. Arya, E. Rovner

Catherine S. Bradley

No abstract provided.


Urodynamically Defined Stress Urinary Incontinence And Bladder Outlet Obstruction Coexist In Women, Catherine Bradley, E. Rovner Apr 2013

Urodynamically Defined Stress Urinary Incontinence And Bladder Outlet Obstruction Coexist In Women, Catherine Bradley, E. Rovner

Catherine S. Bradley

PURPOSE: The definition and significance of female bladder outlet obstruction (BOO) are poorly understood. We identified patients with urodynamic evidence of BOO in a cohort of women with stress urinary incontinence (SUI). MATERIALS AND METHODS: Women with SUI were identified from a videourodynamic data base and pressure flow studies were reexamined. Subjects were excluded if detrusor pressures could not be measured. BOO was diagnosed if the maximum flow rate was less than 12 ml per second and detrusor pressure at maximum flow was greater than 20 cm water or maximum detrusor pressure was greater than 20 cm water in those …


Sexual Function Before And After Non-Surgical Treatment For Stress Urinary Incontinence, V. Handa, E. Whitcomb, A. Weidner, I. Nygaard, L. Brubaker, Catherine Bradley, M. Paraiso, J. Schaffer, H. Zyczynski, M. Zhang, H. Richter Apr 2013

Sexual Function Before And After Non-Surgical Treatment For Stress Urinary Incontinence, V. Handa, E. Whitcomb, A. Weidner, I. Nygaard, L. Brubaker, Catherine Bradley, M. Paraiso, J. Schaffer, H. Zyczynski, M. Zhang, H. Richter

Catherine S. Bradley

OBJECTIVES: (1) to describe sexual function in women seeking treatment of stress urinary incontinence (SUI); (2) to compare the impact on sexual function of three SUI treatments; and (3) to investigate whether non-surgical treatment of SUI is associated with improved sexual function. METHODS: Women with SUI were randomized to continence pessary, behavioral therapy (pelvic floor muscle training and continence strategies), or combination therapy. Sexual function was assessed at baseline and 3-months using short forms of the Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12) and the Personal Experiences Questionnaire (SPEQ). Successful treatment of SUI was assessed with a patient global …


Pharmacologic Treatment For Urgency-Predominant Urinary Incontinence In Women Diagnosed Using A Simplified Algorithm: A Randomized Trial, A. Huang, R. Hess, L. Arya, H. Richter, L. Subak, Catherine Bradley, R. Rogers, D. Myers, K. Johnson, W. Gregory, S. Kraus, M. Schembri, J. Brown Apr 2013

Pharmacologic Treatment For Urgency-Predominant Urinary Incontinence In Women Diagnosed Using A Simplified Algorithm: A Randomized Trial, A. Huang, R. Hess, L. Arya, H. Richter, L. Subak, Catherine Bradley, R. Rogers, D. Myers, K. Johnson, W. Gregory, S. Kraus, M. Schembri, J. Brown

Catherine S. Bradley

OBJECTIVE: The purpose of this study was to evaluate clinical outcomes associated with the initiation of treatment for urgency-predominant incontinence in women diagnosed by a simple 3-item questionnaire. STUDY DESIGN: We conducted a multicenter, double-blinded, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence in ambulatory women diagnosed by the simple 3-item questionnaire. Participants (N = 645) were assigned randomly to fesoterodine therapy (4-8 mg daily) or placebo. Urinary incontinence was assessed with the use of voiding diaries; postvoid residual volume was measured after treatment. RESULTS: After 12 weeks, women who had been assigned randomly to fesoterodine therapy reported 0.9 …


Association Of Vulvar Symptoms With Pelvic Organ Prolapse And Urinary Incontinence, Susan Wing, Catherine Bradley, Colleen Kennedy Apr 2013

Association Of Vulvar Symptoms With Pelvic Organ Prolapse And Urinary Incontinence, Susan Wing, Catherine Bradley, Colleen Kennedy

Catherine S. Bradley

No abstract provided.


Sexual Function In Women After Rectocele Repair With Acellular Porcine Dermis Graft Vs Site-Specific Rectovaginal Fascia Repair, J. Novi, Catherine Bradley, N. Mahmoud, M. Morgan, L. Arya Apr 2013

Sexual Function In Women After Rectocele Repair With Acellular Porcine Dermis Graft Vs Site-Specific Rectovaginal Fascia Repair, J. Novi, Catherine Bradley, N. Mahmoud, M. Morgan, L. Arya

Catherine S. Bradley

The objective of the study was to compare preoperative and postoperative sexual function between women undergoing rectocele repair with porcine dermis graft and women undergoing site-specific repair of rectovaginal fascia. A standardized, validated questionnaire (Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire [PISQ]) was used to collect preoperative sexual function data from 100 patients with rectocele pelvic organ prolapse quantification stage 2 or greater. Fifty women underwent rectocele repair utilizing porcine dermis graft (group 1) and 50 women underwent a site-specific repair of the rectovaginal fascia (group 2). The same questionnaire was administered to all subjects 6 months after surgery. The …