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Full-Text Articles in Medicine and Health Sciences
Measuring Plasma Salicylate Concentrations In All Patients With Drug Overdose Or Altered Consciousness: Is It Necessary?, David Wood, Paul Dargan, Alison Jones
Measuring Plasma Salicylate Concentrations In All Patients With Drug Overdose Or Altered Consciousness: Is It Necessary?, David Wood, Paul Dargan, Alison Jones
Alison L Jones
Background: Salicylate self poisoning is potentially fatal. Plasma salicylate concentrations can be used to guide management when taken in the context of clinical features of toxicity and acid base status. Previous studies in the USA and Hong Kong have shown that routine measurement of plasma salicylate concentrations in all overdose patients is inappropriate, but there have been no previous studies in the UK. Methods: A retrospective case note study from 1 February 2001 to 31 January 2002 was undertaken at the emergency department of St. Thomas’ Hospital, London. Records were reviewed and information on demographic data, history, details of salicylate …
Plasma Salicylate Concentrations Following Overdose; Are They Worth It ?, David Muir Wood, Alison Jones, Paul Dargan
Plasma Salicylate Concentrations Following Overdose; Are They Worth It ?, David Muir Wood, Alison Jones, Paul Dargan
Alison L Jones
Treatment following salicylate ingestion is determined by clinical evidence of toxicity. Previous studies have shown that routine measurement of plasma salicylate concentrations in all overdose patients is unnecessary except in those with clinical features suggestive of salicylate poisoning or in those who are unable to give an accurate history [1]. This retrospective study evaluates whether plasma salicylate concentrations are appropriately measured. A retrospective study of all plasma salicylate concentrations measured in St Thomas’ Hospital Accident and Emergency department from 1 February 2001 to 31 January 2002 was conducted. Admission record cards were surveyed for history of salicylate ingestion, clinical features …
Reduced Packet Sizes May Decrease Paracetamol And Salicylate Self-Poisoning, Paul Dargan, Alison Jones
Reduced Packet Sizes May Decrease Paracetamol And Salicylate Self-Poisoning, Paul Dargan, Alison Jones
Alison L Jones
BACKGROUND Paracetamol is commonly used in cases of deliberate self-poisoning. Overdoses are a major cause of liver failure in the United Kingdom. Legislation introduced in September 1998 aimed to reduce such incidents by restricting the size of over-the-counter paracetamol packaging and including specific health warnings. OBJECTIVE To evaluate the effect of legislative changes restricting ‘over the counter’ paracetamol and salicylate package sizes on self-poisoning rates. SETTING Five liver units and seven general hospitals, United Kingdom; September 1996-September 1999. METHOD Before and after observational study.
An Evidence Based Flowchart To Guide The Management Of Acute Salicylate (Aspirin) Overdose, Paul Dargan, Craig Wallace, Alison Jones
An Evidence Based Flowchart To Guide The Management Of Acute Salicylate (Aspirin) Overdose, Paul Dargan, Craig Wallace, Alison Jones
Alison L Jones
Objective: To develop a flowchart to be used as a tool to guide clinicians step by step through the management of salicylate poisoning. Methods: A comprehensive literature search was carried out. Results: The evidence base was used to develop a management flowchart that guides the clinician through the three main steps in caring for the patient with salicylate poisoning: preventing further absorption, assessing the severity of poisoning and, where appropriate, increasing elimination. Conclusions: Salicylate poisoning can result in severe morbidity and mortality and this flowchart provides an evidence based guideline that will guide clinicians through the management of patients presenting …