Absolute Fracture-Risk Prediction By A Combination Of Calcaneal Quantitative Ultrasound And Bone Mineral Density, John Eisman, Mei Chan, Nguyen Nguyen, Jacqueline Center
Dec 2011
Absolute Fracture-Risk Prediction By A Combination Of Calcaneal Quantitative Ultrasound And Bone Mineral Density, John Eisman, Mei Chan, Nguyen Nguyen, Jacqueline Center
John Eisman
Quantitative ultrasound measurement (QUS)
and bone mineral density (BMD) have each been shown to
predict fracture risk in women. The present study examined
whether a combination of QUS and BMD could improve
the predictive accuracy of fracture risk. This is a population-
based prospective study which involved 454 women
and 445 men aged 62–89 years. Femoral neck BMD
(FNBMD) was measured by DXA and calcaneal QUS was
measured as broadband ultrasound attenuation (BUA) by a
CUBA sonometer. Fragility fracture was ascertained by
X-ray reports during the follow-up period, which took
place between mid-1989 and 2009. During the follow-up
period (median …
Important Risk Factors And Attributable Risk Of Vertebral Fractures In The Population-Based Tromso Study, Svanhild Waterloo, Tuan Nguyen, Luai Awad Ahmed, Jacqueline Center, Bente Morseth, Nguyen Nguyen, John Eisman, Anne Sogaard, Nina Emaus
Dec 2011
Important Risk Factors And Attributable Risk Of Vertebral Fractures In The Population-Based Tromso Study, Svanhild Waterloo, Tuan Nguyen, Luai Awad Ahmed, Jacqueline Center, Bente Morseth, Nguyen Nguyen, John Eisman, Anne Sogaard, Nina Emaus
John Eisman
Fagility fracture is highly prevalent in the general population,
and is increasingly becoming a public health concern
[1,2]. From the age of 60, the lifetime risk of any
fracture in Norway is 63% in women and 34% in men
[3]. Although hip fracture is the most serious consequence
of osteoporosis [4], other osteoporotic fractures
are also associated with important health issues as pain
[5], loss of function [6], and increased risk of new
fractures [7]. Some studies have suggested that clinical
vertebral fractures are associated with increased risk of
subsequent vertebral fractures [8-10], non-vertebral fractures
[11-14], and mortality [15]. Vertebral …
Making The First Fracture The Last Fracture: Asbmr Task Force Report On Secondary Fracture Prevention, John Eisman, Earl Bogoch, Rick Dell, J Timothy Harrington, Ross Mckinney, Alastair Mclellan, Paul Mitchell, Stuart Silverman, Rick Singleton, Ethel Siris
Dec 2011
Making The First Fracture The Last Fracture: Asbmr Task Force Report On Secondary Fracture Prevention, John Eisman, Earl Bogoch, Rick Dell, J Timothy Harrington, Ross Mckinney, Alastair Mclellan, Paul Mitchell, Stuart Silverman, Rick Singleton, Ethel Siris
John Eisman
Fragility fractures are common, affecting almost one in two older women and one in three older men. Every fragility fracture signals
increased risk of future fractures as well as risk of premature mortality. Despite the major health care impact worldwide, currently there
are few systems in place to identify and ‘‘capture’’ individuals after a fragility fracture to ensure appropriate assessment and treatment
(according to national guidelines) to reduce future fracture risk and adverse health outcomes. The Task Force reviewed the current
evidence about different systematic interventional approaches, their logical background, as well as the medical and ethical rationale. This
Peptide Yy Regulates Bone Remodeling In Mice: A Link Between Gut And Skeletal Biology, Iris Wong, Frank Driessler, Ee Cheng Khor, Yanchuan Shi, Birgit Hormer, Amy Nguyen, Ronaldo Enriquez, John Eisman Ao, Amanda Sainsbury, Herbert Herzog, Paul Baldock
Dec 2011
Peptide Yy Regulates Bone Remodeling In Mice: A Link Between Gut And Skeletal Biology, Iris Wong, Frank Driessler, Ee Cheng Khor, Yanchuan Shi, Birgit Hormer, Amy Nguyen, Ronaldo Enriquez, John Eisman Ao, Amanda Sainsbury, Herbert Herzog, Paul Baldock
John Eisman
Background & Aims: Gastrointestinal peptides are increasingly being linked to processes controlling the maintenance of
bone mass. Peptide YY (PYY), a gut-derived satiety peptide of the neuropeptide Y family, is upregulated in some states thatalso display low bone mass. Importantly, PYY has high affinity for Y-receptors, particularly Y1R and Y2R, which are known toregulate bone mass. Anorexic conditions and bariatric surgery for obesity influence circulating levels of PYY and have anegative impact on bone mass, but the precise mechanism behind this is unclear. We thus examined whether alterations inPYY expression affect bone mass.
Methods: Bone microstructure and cellular activity were …
Prevalence Of Vertebral Fractures In Women And Men In The Population-Based Tromso Study, Svanhild Waterloo, Luai Awad Ahmed, Jacqueline Center, John Eisman Ao, Bente Morseth, Nguyen Nguyen, Tuan Nguyen, Anne Sogaard, Nina Emaus
Dec 2011
Prevalence Of Vertebral Fractures In Women And Men In The Population-Based Tromso Study, Svanhild Waterloo, Luai Awad Ahmed, Jacqueline Center, John Eisman Ao, Bente Morseth, Nguyen Nguyen, Tuan Nguyen, Anne Sogaard, Nina Emaus
John Eisman
Background: Osteoporotic vertebral fractures are, as the hip fractures, associated with increased morbidity and
mortality. Norway has one of the highest reported incidences of hip fractures in the world. Because ofmethodological challenges, vertebral fractures are not extensively studied. The aim of this population based studywas to describe, for the first time, the age- and sex specific occurrence of osteoporotic vertebral fractures inNorway.
Methods: Data was collected in the Tromso Study, 2007/8 survey. By the use of dual x-ray absorptiometry (GE
Lunar Prodigy) vertebral fracture assessments were performed in 2887 women and men aged from 38 to 87 years,in addition to …
