Medicine and Health Sciences Commons^™

The Reemergence Of Psychoneuroendocrinology In The Era Of Molecular Neuroscience, Genetics And Imaging, Amresh Srivastava

Amresh Srivastava

Though Psychiatric and neuroscience research has made revolutionary advancements, a number of challenges remain as a barrier in decoding the metrics of psychopathology which intern limits the clinical practice of personalized medicine. In last 20 years a unique direction of research has come to light which provides information about the intricate connections between various findings from the field of neuroimaging, cognition, neurochemistry, molecular biology, immunology and epigenetics. Neurohormores have clearly demonstrated their role in explaining this interrelationship and therefore a possible trajectory for development of mental disorders seem to be visible. Main thrust of investigation which have provided newer insight …

Education And Training For Human Resource Development For Suicide Prevention' In Low And Middle Income Countries, Amresh Srivastava

Amresh Srivastava

Developing countries have more than two-thirds share of suicide in the world with dismal numbers of trained professionals. WHO data shows that more than 90% suicide occurs in the mentally ill individuals. Lack of effective manpower continues to be one of the three main barriers for prevention of suicide world over, particularly in developing countries, followed only by stigma and non-availability of care. Therefore training and education, especially for people, like teachers and health workers, who are in direct contact with vulnerable groups, can help increase identification of individuals with related problems, offer support, and make a referral. Though the …

Neuroendocrines In First Episode Schizophrenia, Amresh Srivastava

Amresh Srivastava

Amresh Shrivastava Environmental factors are acknowledged as key determinants of development of schizophrenia. Studies suggest that the altered expression of genes and proteins involved in numerous neurodevelopmental, metabolic and neurotransmitter pathways can result from inadequate amounts of modulators, transporters and, synthesizers. Advances in the prenatal period in the genesis of schizophrenia suggest that environmental factors and HPA axis may establish a vulnerability to the disease. Further, the onset of psychotic disorders may be associated with a higher rate of stress and change to the hippocampus. Thyroid hormone is a possible link between genes and environment. Its dysfunction has been observed …

Neuroendocrine And Gene-Environment Interaction In Psychiatric Disorders: Current Concepts", Amresh Srivastava

Amresh Srivastava

Abstract Neuroendocrine and gene-environment interaction in psychiatric disorders: current concepts" Amresh Shrivastava, MD The psychiatric disorders are etiologically complex involving both heritable and non-heritable factors. Recent research has indicated that environmental factors, including psychosocial factors, play an important role in manifestation of symptoms. The gap between understanding of those who develop psychiatric illness and those who do not amongst the subgroup of genetic as well as clinical high risk candidates in partly explained by role of environmental factors. These, social, psychological, ecological and cultural factors possibly determine the modulation of biological factors at the level of gene-expression and neuroendocrinal systems. …

Re-Hospitalization Of Psychiatric Patients: The Patients, Or The Illness And Treatment?, Amresh Srivastava, Robbie Campbell, Megan Johnston, Ruth Mooser, Larry Stitt

Amresh Srivastava

Purpose: The goal of this project was to find out why psychiatric patients get hospitalised repeatedly. Studies have found that repeated hospitalization leads to economic drain, disability, poor outcome, stigma and discrimination. Hospitalization consumes more than 90% of mental health budgets. Identifying the potential risk factors for repeated hospitalization, interrelationships between risk factors, and vulnerability will help us take the appropriate measures to prevent hospitalization and promote care in the community. Logistically, there are three possible factors which may lead to repeated hospitalization: (1) Characteristics of the patient; (2) Nature of the illness; and (3) The management of the illness …

Experience And Evaluation Of Hospital-Based Training Of University Teachers For Suicide Prevention In Mumbai, India, Amresh Srivastava

Amresh Srivastava

Amresh Shrivastava, Shubhangi Parkar, Nilesh Shah Background In India suicide rates high amongst student’s population with rising numbers of student’s suicide. The National Crime Research Bauru (NCRB) the Government of India reopots that approximately 2.% suicide takes place due to failure in examination, needless to say it remains grossly underreported due to several causes.eg. legal hassels The intervention strategy for dealing with mental health issues of students is particularly dependent upon awareness about suicide amongst the parsons who are in direct touch with them. The teachers of the colleges are in an advantageous position because they are in direct touch …

Should ‘Risk Syndrome Of Psychosis’ Be Included In Dsm V As A Diagnosis? A Road Towards Preventive Psychiatry”, Amresh Srivastava

Amresh Srivastava

Psychiatric diagnosis has acquired a position of a quasi-legal document for mental health services and agencies working with mental health. Its utility has gone far beyond ‘clinical diagnosis for treatment’.

The concept of risk syndrome for schizophrenia has been thoroughly researched in last ten years or so. Significant advancement has been made in phenomenology, diagnostic criteria, classification, & neurobiology. The research of prodromal or at-risk or Ultra high-risk psychosis has significantly contributed to the body of knowledge of aetio-pathogenesis of schizophrenia.

The science of risk syndrome has apparently matured and its proponents are ready for its inclusion in DSM V …

Outcome, Early Intervention & Dup: The Matrix Of Research In Early Psychosis, Amresh Srivastava, Megan Johnston

Amresh Srivastava

There has been little investigation of the relationship of DUP to other long-term outcomes such as negative symptoms and cognitive functioning neither have the possible confounds of DUP been widely investigated or controlled. It is important that there should be more thorough investigations of DUP, its correlates, and the extent to which it does mediate any advantages of earlier intervention. Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes. At the time of treatment initiation, duration of initially untreated psychosis was associated …