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Thimerosal Induces Apoptosis In A Neuroblastoma Model Via The Cjun N-Terminal Kinase Pathway, Michelle Herdman, Aileen Marcello, Ying Huang, Richard Niles, Sanjit Dhar, Kinsley Kinningham
Thimerosal Induces Apoptosis In A Neuroblastoma Model Via The Cjun N-Terminal Kinase Pathway, Michelle Herdman, Aileen Marcello, Ying Huang, Richard Niles, Sanjit Dhar, Kinsley Kinningham
Richard M Niles
The cJun N-terminal kinase (JNK)-signaling pathway is activated in response to a variety of stimuli, including environmental insults, and has been implicated in neuronal apoptosis. In this study, we investigated the role that the JNK pathway plays in neurotoxicity caused by thimerosal, an ethylmercury-containing preservative. SK-N-SH cells treated with thimerosal (0-10 microM) showed an increase in the phosphorylated (active) form of JNK and cJun with 5 and 10 microM thimerosal treatment at 2 and 4 h. To examine activator protein-1 (AP-1) transcription, cells were transfected with a pGL2 vector containing four AP-1 consensus sequences and then treated with thimerosal (0-2.5 …