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Modulation Of Ischaemic Contracture In Mouse Hearts: A 'Supraphysiological' Response To Adenosine, Melissa Reichelt, Laura Willems, Jason Peart, Kevin Ashton, G Matherne, Michael Blackburn, John Headrick
Modulation Of Ischaemic Contracture In Mouse Hearts: A 'Supraphysiological' Response To Adenosine, Melissa Reichelt, Laura Willems, Jason Peart, Kevin Ashton, G Matherne, Michael Blackburn, John Headrick
Kevin Ashton
While inhibition of ischaemic contracture was one of the first documented cardioprotective actions of exogenously applied adenosine, it is not known whether this is a normal function of endogenous adenosine generated during ischaemic stress. Additionally, the relevance of delayed contracture to postischaemic outcome is unclear. We tested the ability of endogenous versus exogenous adenosine to modify contracture (and postischaemic outcomes) in C57/Bl6 mouse hearts. During ischaemia, untreated hearts developed peak contracture (PC) of 85 ± 5 mmHg at 8.9 ± 0.8 min, with time to reach 20 mmHg (time to onset of contracture; TOC) of 4.4 ± 0.3 min. Adenosine …