Medicine and Health Sciences Commons^™

Risk Factors For Persistent Problems Following Whiplash Injury: Results Of A Systematic Review And Meta-Analysis, David Walton

David Walton

No abstract provided.

Messengers From The Past, Anastasia Tsaliki

Anastasia Tsaliki

Participation in this documentary directed by Gianni Minelli and produced by Zeeva Production in English and in Italian.

"On September 26th, 1997, a violent earthquake shook central Italy. The effects were devastating. Television stations from all over the world broadcasted images of the incomparable artistic heritage that risked being destroyed forever. In Monsanpolo del Tronto, a small town in the Marches, the earthquake damaged the beautiful church Maria Santissima Assunta. A few years later, during the restoration of the church, a sensational discovery was made: twenty perfectly preserved mummies from the middle of the sixteenth century wearing their original clothes. …

Diabetic Rates And Mice Are Resistent To Porcine And Human Insulin: Flawed Experimental Models For Testing Islet Xenograft, A. Pepper, C. Gall, D. Mazzuca, C.W.J. Melling, D. White

Jamie Melling

BACKGROUND: Islet transplantation is potentially a promising therapy for the restoration of carbohydrate control to diabetic patients. However, the global application of islet transplantation requires a ubiquitous source of beta cells. The xenotransplantation of porcine islets would provide such a source. Success in porcine islet xenografting has been achieved in diabetic primates. However, there are few reports of reversal of diabetes with porcine islet xenografts in rodent models of diabetes, relative to the number of successful rodent experiments performed as allografts. Here we report for the first time the inability of porcine (and human) insulin to control blood glucose levels …

Myocardial Hsp70 Phosphorylation And Pkc-Mediated Cardioprotection Following Exercise, C.W. Melling, David Thorp, Kevin Milne, Earl Noble

Jamie Melling

Both protein kinase C (PKC) activation and Hsp70 expression have been shown to be key components for exercise-mediated myocardial protection during ischemia–reperfusion injury. Given that Hsp70 has been shown to undergo inducible phosphorylation in striated muscle and liver, we hypothesized that PKC may regulate myocardial Hsp70 function and subsequent exercise-conferred cardioprotection through this phosphorylation. Hence, acute exercise of male Sprague–Dawley rats (30 m/min for 60 min at 2% grade) was employed to assess the role of PKC and its selected isoforms in phosphorylation of Hsp70 and protection of the myocardium during ischemia-reperfusion injury. It was observed that administration of the …