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School of Biological Sciences: Dissertations, Theses, and Student Research
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Evolution Of Human Immunodeficiency Virus Type 1 Clade C Envelope V1-V5 Region During Disease Progression In Non-Human Primate Model, For Yue Tso
School of Biological Sciences: Dissertations, Theses, and Student Research
Human immunodeficiency virus type 1 (HIV-1) clade C strain is the fastest spreading HIV-1 strain globally, especially in Africa. It has been decades since the acquired immune deficiency syndrome (AIDS) pandemic first started. However, an effective anti-HIV-1 vaccine is not yet available, which is partly due to the highly variable nature of HIV-1 envelope gene and the absence of a suitable animal model. Strengthening of the understanding of envelope evolution during disease progression will contribute significantly towards future anti-HIV-1 treatment and preventions.
Non-human primates have been an essential animal model for many biomedical research areas. Using simian-human immunodeficiency virus (SHIV) …