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Veterinary Medicine

Chondroitin sulfate

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Endoscopic Evaluation Of Gastric Mucosa To Determine Safety Of Three Chondroprotective Drugs In Healthy Dogs, Korakot Nganvongpanit, Kittipong Kungprathum, Terdsak Yano, Kumpanart Soontornvipart Sep 2013

Endoscopic Evaluation Of Gastric Mucosa To Determine Safety Of Three Chondroprotective Drugs In Healthy Dogs, Korakot Nganvongpanit, Kittipong Kungprathum, Terdsak Yano, Kumpanart Soontornvipart

The Thai Journal of Veterinary Medicine

This randomized, double-blind, placebo-controlled study investigated the effects of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein on the gastric mucosa of dogs, and on clinical signs of vomiting and diarrhea. Twenty-one healthy adult dogs were included in the study, and were randomly assigned to seven treatment groups, 3 dogs per group. The effect of those medicines on the gastric mucosa was evaluated by endoscopy on day 3 and day 14, and compared with pre-treatment. Clinical signs, including vomiting and diarrhea, were recorded every day during the study period. The results showed a non-significant effect of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein …

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Redistribution Of Insoluble Interphotoreceptor Matrix Components During Photoreceptor Differentiation In The Mouse Retina, Kristina Mieziewska, Agoston Szel, Theo Van Veen, Gustavo D. Aguirre, Nancy Philp Jun 1994

Redistribution Of Insoluble Interphotoreceptor Matrix Components During Photoreceptor Differentiation In The Mouse Retina, Kristina Mieziewska, Agoston Szel, Theo Van Veen, Gustavo D. Aguirre, Nancy Philp

Gustavo D. Aguirre, VMD, PhD

The development of the nervous-system is largely influenced by the extracellular matrix (ECM). In the neural retina, the photoreceptors are surrounded by a unique ECM, the interphotoreceptor matrix (IPM). The IPM plays a central and possibly crucial role in the development, maintenance and specific function of the photoreceptors. Therefore, the characterization of IPM components is necessary to understand the mechanisms regulating photoreceptor differentiation.

The IPM in the mouse retina was examined during photoreceptor morphogenesis with the monoclonal antibody (MAb) F22, which recognizes a 250 kDa component of the interphotoreceptor matrix. The binding pattern of MAb F22 revealed a striking redistribution …

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