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Caspase-1, -2, And -3 Gene Expression Is Enhanced In The Heart And Lung Of Chickens With Pulmonary Hypertension (Ascites), Hossein Hassanpour, Masood Teshfam, Hassan Momtaz, Hamed Zarei, Shahab Bahadoran
Caspase-1, -2, And -3 Gene Expression Is Enhanced In The Heart And Lung Of Chickens With Pulmonary Hypertension (Ascites), Hossein Hassanpour, Masood Teshfam, Hassan Momtaz, Hamed Zarei, Shahab Bahadoran
Turkish Journal of Veterinary & Animal Sciences
To investigate the involvement of apoptosis in the pathogenesis of T3-induced pulmonary hypertension in broiler chickens, caspase-1, -2, and -3 gene expressions were evaluated by semiquantitative RT-PCR in the lungs and left and right heart ventricles. One-day-old fast-growing chickens were randomly divided into 2 equal groups with 3 replicates per group. Chicks were reared for 7 weeks under standard conditions. T3 as a thyroid hormone was added to the ration after week 1 of rearing. Pulmonary hypertension was induced at 49 days based on RV/TV ratio index. The caspase genes were constitutively expressed in the lung and right and left …