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A Review Of The Pharmacology, Pharmacokinetics And Behavioral Effects Of Procaine In Thoroughbred Horses, Thomas Tobin, J. W. Blake
A Review Of The Pharmacology, Pharmacokinetics And Behavioral Effects Of Procaine In Thoroughbred Horses, Thomas Tobin, J. W. Blake
Maxwell H. Gluck Equine Research Center Faculty Publications
Since procaine has both local anaesthetic and central stimulant actions its presence in the blood or urine of racing horses is forbidden. After rapid intravenous injection of procaine HC1 (2.5 mg/Kg) in thoroughbred mares plasma levels of this drug fell rapidly (t 1/2 alpha = 5 min) and then more slowly (t 1/2 beta = 50.2 min). These kinetics were well fitted by a two compartment open model (Model I). This model gave an apparent Vdbeta for procaine in the horse of about 3,500 litres. Since procaine was about 45% bound to equine plasma protein this gives a true Vdbeta …
The Gas-Liquid Chromatograph And The Electron Capture Detection In Equine Drug Testing., J. W. Blake, Thomas Tobin
The Gas-Liquid Chromatograph And The Electron Capture Detection In Equine Drug Testing., J. W. Blake, Thomas Tobin
Maxwell H. Gluck Equine Research Center Faculty Publications
Three gas-liquid chromatographic (G.L.C.) procedures discussed have been designed around the four "esses" of detection tests--speed, sensitivity, simplicity, and specificity. These techniques are admirably applicable to the very low plasma drug levels encountered in blood testing under pre-race conditions. The methods are equally applicable to post-race testing procedures, where both blood and urine samples are tested. Drugs can only rarely be detected by the electron capture detector (E.C.D.) without a prior derivatization step, which conveys to the drug(s) high electron affinity. Because of broad applicability, two derivatizing agents, heptafluorobutyric (HFBA) and pentafluorpropionic (PFPA) anhydrides are employed. The three techniques, allowing …