Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Estrogen And Progesterone Induce Persistent Increases In P53-Dependent Apoptosis And Suppress Mammary Tumors In Balb/C-Trp53+/- Mice, Karen Dunphy, Anneke C. Blackburn, Haoheng Yan, Lauren R. O'Connell, D Joseph Jerry
Estrogen And Progesterone Induce Persistent Increases In P53-Dependent Apoptosis And Suppress Mammary Tumors In Balb/C-Trp53+/- Mice, Karen Dunphy, Anneke C. Blackburn, Haoheng Yan, Lauren R. O'Connell, D Joseph Jerry
Karen Dunphy
Introduction Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome. Methods Mice that differ in p53 status (Trp53+/+, Trp53+/-, Trp53-/-) were treated with E+P for 14 days and then were tested for p53-dependent responses to ionizing radiation. Responses were also examined in parous and age-matched virgins. The effects of hormonal exposures on tumor …