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Full-Text Articles in Medicine and Health Sciences
Mycoplasma Haemocanis – The Canine Hemoplasma And Its Feline Counterpart In The Genomic Era, Naila C. Do Nascimento, Andrea P. Santos, Ana Ms Guimaraes, Phillip J. Sanmiguesl, Joanne Messick
Mycoplasma Haemocanis – The Canine Hemoplasma And Its Feline Counterpart In The Genomic Era, Naila C. Do Nascimento, Andrea P. Santos, Ana Ms Guimaraes, Phillip J. Sanmiguesl, Joanne Messick
Department of Comparative Pathobiology Faculty Publications
Mycoplasma haemocanis is a hemotrophic mycoplasma (hemoplasma), blood pathogen that may cause acute disease in immunosuppressed or splenectomized dogs. The genome of the strain Illinois, isolated from blood of a naturally infected dog, has been entirely sequenced and annotated to gain a better understanding of the biology of M. haemocanis. Its single circular chromosome has 919 992 bp and a low G + C content (35%), representing a typical mycoplasmal genome. A gene-by-gene comparison against its feline counterpart, M. haemofelis, reveals a very similar composition and architecture with most of the genes having conserved synteny extending over their entire chromosomes …
The Effect Of Infection Order Of Porcine Circovirus Type 2 And Porcine Reproductive And Respiratory Syndrome Virus On Dually Infected Swine Alveolar Macrophages, Yi-Chieh Tsai, Hui-Wen Chang, Chian-Ren Jeng, Tsang L. Lin, Chun-Ming Lin, Cho-Hua Wan, Victor Fei Pang
The Effect Of Infection Order Of Porcine Circovirus Type 2 And Porcine Reproductive And Respiratory Syndrome Virus On Dually Infected Swine Alveolar Macrophages, Yi-Chieh Tsai, Hui-Wen Chang, Chian-Ren Jeng, Tsang L. Lin, Chun-Ming Lin, Cho-Hua Wan, Victor Fei Pang
Department of Comparative Pathobiology Faculty Publications
Abstract Background: Concurrent infection with porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) is known as one of the major causes for porcine respiratory disease complex (PRDC). Dual infection with PCV2 and PRRSV is consistently to have more severe clinical presentations and pulmonary lesions than infection with PCV2 alone or PRRSV alone. However, it is not known if dual infections with PCV2 and PRRSV in different infection order may lead to different clinical symptoms in the host. To mimic the possible field conditions, swine alveolar macrophages (AMs) were inoculated with PCV2 and PRRSV in vitro …
Impact Of Preexisting Adenovirus Vector Immunity On Immunogenicity And Protection Conferred With An Adenovirus-Based H5n1 Influenza Vaccine, Aseem Pandey, Neetu Singh, Sai V. Vemula, Laurent Couetil, Jacqueline M. Katz, Ruben Donis, Suryaprakash Sambhara, Suresh K. Mittal
Impact Of Preexisting Adenovirus Vector Immunity On Immunogenicity And Protection Conferred With An Adenovirus-Based H5n1 Influenza Vaccine, Aseem Pandey, Neetu Singh, Sai V. Vemula, Laurent Couetil, Jacqueline M. Katz, Ruben Donis, Suryaprakash Sambhara, Suresh K. Mittal
Department of Comparative Pathobiology Faculty Publications
The prevalence of preexisting immunity to adenoviruses in the majority of the human population might adversely impact the development of adaptive immune responses against adenovirus vector-based vaccines. To address this issue, we primed BALB/c mice either intranasally (i.n.) or intramuscularly (i.m.) with varying doses of wild type (WT) human adenovirus subtype 5 (HAd5). Following the development of immunity against HAd5, we immunized animals via the i.n. or i.m. route of inoculation with a HAd vector (HAd-HA-NP) expressing the hemagglutinin (HA) and nucleoprotein (NP) of A/Vietnam/1203/ 04 (H5N1) influenza virus. The immunogenicity and protection results suggest that low levels of vector …
Zwitterionic Chitosan Derivative, A New Biocompatible Pharmaceutical Excipient, Prevents Endotoxin-Mediated Cytokine Release, Gaurav Bajaj, William G. Van Alstine, Yoon Yeo
Zwitterionic Chitosan Derivative, A New Biocompatible Pharmaceutical Excipient, Prevents Endotoxin-Mediated Cytokine Release, Gaurav Bajaj, William G. Van Alstine, Yoon Yeo
Department of Comparative Pathobiology Faculty Publications
Chitosan is a cationic polymer of natural origin and has been widely explored as a pharmaceutical excipient for a broad range of biomedical applications. While generally considered safe and biocompatible, chitosan has the ability to induce inflammatory reactions, which varies with the physical and chemical properties. We hypothesized that the previously reported zwitterionic chitosan (ZWC) derivative had relatively low pro-inflammatory potential because of the aqueous solubility and reduced amine content. To test this, we compared various chitosans with different aqueous solubilities or primary amine contents with respect to the intraperitoneal (IP) biocompatibility and the propensity to induce proinflammatory cytokine production …