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Full-Text Articles in Medicine and Health Sciences
Complete Genome Sequence Of An Astrovirus Identified In A Domestic Rabbit (Oryctolagus Cuniculus) With Gastroenteritis, Mark D. Stenglein, Eric Velazques, Cheryl Greenacre, Rebecca P. Wilkes, J. G. Ruby, Julia S. Lankton, Donald Ganem, Melissa A. Kennedy, Joseph L. Derisi
Complete Genome Sequence Of An Astrovirus Identified In A Domestic Rabbit (Oryctolagus Cuniculus) With Gastroenteritis, Mark D. Stenglein, Eric Velazques, Cheryl Greenacre, Rebecca P. Wilkes, J. G. Ruby, Julia S. Lankton, Donald Ganem, Melissa A. Kennedy, Joseph L. Derisi
Animal Science Publications and Other Works
A colony of domestic rabbits in Tennessee, USA, experienced a high-mortality (~90%) outbreak of enterocolitis. The clinical characteristics were one to six days of lethargy, bloating, and diarrhea, followed by death. Heavy intestinal coccidial load was a consistent finding as was mucoid enteropathy with cecal impaction. Preliminary analysis by electron microscopy revealed the presence of virus-like particles in the stool of one of the affected rabbits. Analysis using the Virochip, a viral detection microarray, suggested the presence of an astrovirus, and follow-up PCR and sequence determination revealed a previously uncharacterized member of that family. Metagenomic sequencing enabled the recovery of …