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Comparison Of The Effect Of Pressure Loading On Left Ventricular Size, Systolic And Diastolic Function In Canines With Left Ventricular Dysfunction With Preserved And Reduced Ejection Fraction, Steven J. Lavine, Donald A. Conetta
Comparison Of The Effect Of Pressure Loading On Left Ventricular Size, Systolic And Diastolic Function In Canines With Left Ventricular Dysfunction With Preserved And Reduced Ejection Fraction, Steven J. Lavine, Donald A. Conetta
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Decompensated heart failure may present with severe hypertension in patients with preserved (PreEF) or reduced left ventricular (LV) ejection fraction (RedEF) and is clinically indistinguishable. Previously, we demonstrated that arterial pressure elevation increases LV filling pressures in a canine model of chronic LV dysfunction with PreEF or RedEF. It is not clear whether any differences in hemodynamics, LV volume or performance, or diastolic function can be demonstrated between canines with PreEF or RedEF in response to arterial pressure elevation. We hypothesized that the LV systolic, diastolic, and hemodynamic response to pressure loading would be similar in RedEF or …