Medicine and Health Sciences Commons^™

Associations Of Passerine Birds, Rabbits, And Ticks With Borrelia Miyamotoi And Borrelia Andersonii In Michigan, U.S.A., Sarah A. Hamer, Graham J. Hickling, Rich Keith, Jennifer L. Sidge, Edward D. Walker, Jean I. Tsao

Animal Science Publications and Other Works

Background

Wild birds contribute to maintenance and dissemination of vectors and microbes, including those that impact human, domestic animal, and wildlife health. Here we elucidate roles of wild passerine birds, eastern cottontail rabbits (Sylvilagus floridanus), and Ixodes dentatus ticks in enzootic cycles of two spirochetes, Borrelia miyamotoi and B. andersonii in a region of Michigan where the zoonotic pathogen B. burgdorferi co-circulates.

Methods

Over a four-year period, wild birds (n = 19,631) and rabbits (n = 20) were inspected for tick presence and ear tissue was obtained from rabbits. Samples were tested for Borrelia spirochetes using nested PCR …

Discovery Fall 2012, Misty Bailey

Discovery Research Newsletter

No abstract provided.

Subcongenic Analysis Of Tabw2 Obesity Qtl On Mouse Chromosome 6, Taryn P. Stewart, Xia Mao, Maha N. Aqqad, Dean Uffort, Kristy D. Dillon, Arnold M. Saxton, Jung H. Kim

Animal Science Publications and Other Works

Background

We previously established a congenic mouse strain with TALLYHO/Jng (TH) donor segment on chromosome 6 in a C57BL/6 (B6) background that harbors an obesity quantitative trait locus, tabw2. The B6.TH-tabw2 congenic mice developed increased adiposity that became exacerbated upon feeding a high fat-high sucrose (HFS) diet. To fine map the tabw2, in this study we generated and characterized subcongenic lines with smaller TH donor segments.

Results

We fixed four subcongenic lines, with maximum size of donor segment retained in the lines ranging from 10.8 – 92.5 Mb. For mapping, all the subcongenic mice, along with B6.TH- …

Complete Genome Sequence Of An Astrovirus Identified In A Domestic Rabbit (Oryctolagus Cuniculus) With Gastroenteritis, Mark D. Stenglein, Eric Velazques, Cheryl Greenacre, Rebecca P. Wilkes, J. G. Ruby, Julia S. Lankton, Donald Ganem, Melissa A. Kennedy, Joseph L. Derisi

Animal Science Publications and Other Works

A colony of domestic rabbits in Tennessee, USA, experienced a high-mortality (~90%) outbreak of enterocolitis. The clinical characteristics were one to six days of lethargy, bloating, and diarrhea, followed by death. Heavy intestinal coccidial load was a consistent finding as was mucoid enteropathy with cecal impaction. Preliminary analysis by electron microscopy revealed the presence of virus-like particles in the stool of one of the affected rabbits. Analysis using the Virochip, a viral detection microarray, suggested the presence of an astrovirus, and follow-up PCR and sequence determination revealed a previously uncharacterized member of that family. Metagenomic sequencing enabled the recovery of …

Socioeconomic Determinants Of Geographic Disparities In Campylobacteriosis Risk: A Comparison Of Global And Local Modeling Approaches, Jennifer Weisent, Barton Rohrbach, John R. Dunn, Agricola Odoi

Animal Science Publications and Other Works

Background

Socioeconomic factors play a complex role in determining the risk of campylobacteriosis. Understanding the spatial interplay between these factors and disease risk can guide disease control programs. Historically, Poisson and negative binomial models have been used to investigate determinants of geographic disparities in risk. Spatial regression models, which allow modeling of spatial effects, have been used to improve these modeling efforts. Geographically weighted regression (GWR) takes this a step further by estimating local regression coefficients, thereby allowing estimations of associations that vary in space. These recent approaches increase our understanding of how geography influences the associations between determinants and …

Metabr: An R Script For Linear Model Analysis Of Quantitative Metabolomic Data, Ben Ernest, Jessica R. Gooding, Shawn R. Campagna, Arnold M. Saxton, Brynn H. Voy

Faculty Publications and Other Works -- Small Animal Clinical Sciences

Background

Metabolomics is an emerging high-throughput approach to systems biology, but data analysis tools are lacking compared to other systems level disciplines such as transcriptomics and proteomics. Metabolomic data analysis requires a normalization step to remove systematic effects of confounding variables on metabolite measurements. Current tools may not correctly normalize every metabolite when the relationships between each metabolite quantity and fixed-effect confounding variables are different, or for the effects of random-effect confounding variables. Linear mixed models, an established methodology in the microarray literature, offer a standardized and flexible approach for removing the effects of fixed- and random-effect confounding variables from …

Anesthesia Of The Geriatric Equine, Reza Seddighi Dvm, Ms, Phd, Dip Acva, Cvma

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Advancements in veterinary medicine have resulted in an increased number of geriatric horses being presented for medical or surgical procedures that require general anesthesia. Due to the physiological changes associated with aging and the likelihood of concurrent disease conditions, the geriatric equine is at an increased risk during anesthesia. The main physiological changes associated with aging, and their impact on anesthesia, are discussed in this review.

The Internet And Health Information: Differences In Pet Owners Based On Age, Gender, And Education, Lori R. Kogan, Regina Schoenfeld-Tacher, Ann R. Viera

Faculty Publications and Other Works -- Small Animal Clinical Sciences

Objective:

The research assessed the attitudes and behaviors of pet owners pertaining to online search behavior for pet health information.

Methods:

A survey was conducted with a random sample of pet owners drawn from two US metropolitan areas and surrounding cities. Participating clinics were chosen randomly, and each participating clinic was asked to distribute 100 surveys to their clients until all surveys were disbursed.

Results:

Although some perceptions and behaviors surrounding the use of the Internet for pet health information differ based on gender, age, or education level of pet owners, there are many aspects in which there are no …

Volume 9, Number 1 (Spring/Summer 2012), Ut Institute Of Agriculture

Tennessee Land, Life and Science Magazine

Issue Highlights:

• UT Veterinary Medicine Center Treats Smokey
• Farm Credit Services Creates Top Scholars Program
• Perspective on the Importance and Future of the Institute

Transcriptomic And Metabolomic Profiling Of Chicken Adipose Tissue In Response To Insulin Neutralization And Fasting, Bo Ji, Ben Ernest, Jessica R. Gooding, Suchita Das, Arnold M. Saxton, Jean Simon, Joelle Dupont, Sonia Métayer-Coustard, Shawn R. Campagna, Brynn H. Voy

Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences

Background

Domestic broiler chickens rapidly accumulate adipose tissue due to intensive genetic selection for rapid growth and are naturally hyperglycemic and insulin resistant, making them an attractive addition to the suite of rodent models used for studies of obesity and type 2 diabetes in humans. Furthermore, chicken adipose tissue is considered as poorly sensitive to insulin and lipolysis is under glucagon control. Excessive fat accumulation is also an economic and environmental concern for the broiler industry due to the loss of feed efficiency and excessive nitrogen wasting, as well as a negative trait for consumers who are increasingly conscious of …

Comparison Of High Fiber And Low Carbohydrate Diets On Owner-Perceived Satiety Of Cats During Weight Loss, Martha Cline, Angela Witzel, Tamberlyn Moyers, Joseph Bartges, Claudia Kirk

Faculty Publications and Other Works -- Small Animal Clinical Sciences

Food-seeking behaviors exhibited by cats during weight loss programs are frustrating to owners. Two categories of therapeutic weight loss diets are available for cats: High Fiber (HF) and Low Carbohydrate (LC). The objective of this study was to determine if cat owners perceive a difference in satiety when their cats are fed either a HF or LC diet during a weight loss regimen. Twenty-eight client-owned cats were randomly assigned to either an HF or LC canned diet and fed to 80% of their ideal weight resting energy requirements. Cats were rechecked at 2, 4, 6 and 8 weeks and food …

Volume 9, Number 2 (Fall/Winter 2012), Ut Institute Of Agriculture

Tennessee Land, Life and Science Magazine

Issue Highlights:

• The Plight of Pollinators: Working to Sustain Our Food Supply
• Celebrating a Land-Grant Milestone
• UT Researchers Devise New Precision Ag Technology

Does Place Of Residence Affect Risk Of Suicide? A Spatial Epidemiologic Investigation In Kentucky From 1999 To 2008, Daniel M. Saman, Sabrina Walsh, Anna Borówko, Agricola Odoi

Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences

Background

Approximately 32,000 people take their own lives every year in the United States. In Kentucky, suicide mortality rates have been steadily increasing since 1999. Few studies in the United States have assessed spatial clustering of suicides. The purpose of this study was to identify high-risk clusters of suicide at the county level in Kentucky and assess the characteristics of those suicide cases within the clusters.

Methods

A spatial epidemiological study was undertaken using suicide data for the period January 1, 1999 to December 31, 2008, obtained from the Kentucky Office of Vital Statistics. Descriptive analyses using Pearson's chi-square test …

Socioeconomic Determinants Of Geographic Disparities In Campylobacteriosis Risk: A Comparison Of Global And Local Modeling Approaches, Jennifer Weisent, Barton Rohrbach, John R. Dunn, Agricola Odai

Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences

Background

Socioeconomic factors play a complex role in determining the risk of campylobacteriosis. Understanding the spatial interplay between these factors and disease risk can guide disease control programs. Historically, Poisson and negative binomial models have been used to investigate determinants of geographic disparities in risk. Spatial regression models, which allow modeling of spatial effects, have been used to improve these modeling efforts. Geographically weighted regression (GWR) takes this a step further by estimating local regression coefficients, thereby allowing estimations of associations that vary in space. These recent approaches increase our understanding of how geography influences the associations between determinants and …

In Vitro Investigation Of A Terbinafine Impregnated Subcutaneous Implant For Veterinary Use, Marcy J. Souza, Tim Cairns, Jason Yarbrough, Sherry Cox

Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences

No abstract provided.

Center Of Excellence In Livestock Diseases And Human Health Annual Report, College Of Veterinary Medicine

Center of Excellence Annual Reports

The center was created in 1984 to promote interdisciplinary activities designed to improve the quality of human life through better animal health; expand livestock disease research capabilities in the College of Veterinary Medicine (UTCVM) and the Institute of Agriculture; identify and characterize animal diseases that are similar to human disease; and develop new strategies for the diagnosis, treatment, and prevention of disease.

Since 1984, the center has developed successful programs that affect the understanding, treatment, and prevention of livestock and human diseases. These programs predominately focus on molecular and cellular approaches to research in infectious diseases, toxicology, host defense, molecular …