Medicine and Health Sciences Commons^™

Sequence-Based Antigenic Change Prediction By A Sparse Learning Method Incorporating Co-Evolutionary Information., Jialiang Yang, Tong Zhang, Xiu-Feng Wan

College of Veterinary Medicine Publications and Scholarship

Rapid identification of influenza antigenic variants will be critical in selecting optimal vaccine candidates and thus a key to developing an effective vaccination program. Recent studies suggest that multiple simultaneous mutations at antigenic sites accumulatively enhance antigenic drift of influenza A viruses. However, pre-existing methods on antigenic variant identification are based on analyses from individual sites. Because the impacts of these co-evolved sites on influenza antigenicity may not be additive, it will be critical to quantify the impact of not only those single mutations but also multiple simultaneous mutations or co-evolved sites. Here, we developed and applied a computational method, …