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Carprofen-Induced Oxidative Stress In Mitochondria Of The Colonic Mucosa Of The Dog, Lynne A. Snow Jan 2010

Carprofen-Induced Oxidative Stress In Mitochondria Of The Colonic Mucosa Of The Dog, Lynne A. Snow

LSU Master's Theses

Objectives 1) To measure conductance and permeability of canine colonic mucosa exposed to increasing concentrations of carprofen. 2) To compare conductance and permeability of canine colonic mucosa exposed to carprofen or 2,4-dinitrophenol (DNP) and tempol blockade. Design In vitro randomized block design Animal 20 mixed breed dogs Methods Conductance, mannitol flux, and histology were evaluated in colonic mucosa mounted in Ussing chambers. Mucosa was first exposed to increasing concentrations of carprofen. Mucosa was then exposed to either carprofen (200 μg/ml) or DNP (0.25mM) +/- tempol (1mM) pretreatment. Conductance over time, mannitol fluxes, and frequency of histologic categories were analyzed for …


Applicability And Integration Of Plasma Sprayed Hydroxyapatite Coated Ao Cortical Bone Screws In Equine Bone, Timm Gudehus Jan 2010

Applicability And Integration Of Plasma Sprayed Hydroxyapatite Coated Ao Cortical Bone Screws In Equine Bone, Timm Gudehus

LSU Master's Theses

To compare insertion temperatures and torques of Hydroxyapatite (HA) coated and uncoated 5.5 mm AO cortical screws in equine third metatarsal bones (MTIII) in vitro, and to compare insertion and extraction torques of HA coated and uncoated screws after 4, 8, 12 and 16 weeks of healing in equine third metacarpal bones (MCIII) in vivo. No significant temperature differences were recorded in cadaveric bones for AO and HA coated screws. Insertion torques were significantly higher for HA coated implants compared to uncoated screws. In vivo, the AO screws lost 50% of their initial stability within 4 weeks of healing and …