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Full-Text Articles in Medicine and Health Sciences
Protection Of Retinal Cells From Ischemia By A Novel Gap Junction Inhibitor, Satyabrata Das, Dingo Lin, Snehalata Jena, Aibin Shi, Srinivas Battina, Duy H. Hua, Rachel A. Allbaugh, Dolores J. Takemoto
Protection Of Retinal Cells From Ischemia By A Novel Gap Junction Inhibitor, Satyabrata Das, Dingo Lin, Snehalata Jena, Aibin Shi, Srinivas Battina, Duy H. Hua, Rachel A. Allbaugh, Dolores J. Takemoto
Rachel A. Allbaugh
Retinal cells which become ischemic will pass apoptotic signal to adjacent cells, resulting in the spread of damage. This occurs through open gap junctions. A class of novel drugs, based on primaquine (PQ), was tested for binding to connexin 43 using simulated docking studies. A novel drug has been synthesized and tested for inhibition of gap junction activity using R28 neuro-retinal cells in culture. Four drugs were initially compared to mefloquine, a known gap junction inhibitor. The drug with optimal inhibitory activity, PQ1, was tested for inhibition and was found to inhibit dye transfer by 70% at 10 μM. Retinal …
Behavioral Effects Of Contraception Management: The Use Of Porcine Zona Pellucida On Wild Horses, Cassandra M.V. Nuñez
Behavioral Effects Of Contraception Management: The Use Of Porcine Zona Pellucida On Wild Horses, Cassandra M.V. Nuñez
Cassandra M.V. Nuñez
The advent of immunocontraception with porcine zona pellucida (PZP) has all but revolutionized wild horse management, providing a more humane method of population control than earlier strategies. Early studies on Assateague Island National Seashore have described it as an ideal form of fertility control in that it reduces the chance of conception to below 10%, can be delivered remotely, is reversible (after short-term use), lacks debilitating physiological side effects, cannot pass through the food chain, and shows minimal effects on social behaviors. However, recent research in other populations has revealed behavioral and physiological side effects of long-term PZP use. These …