Medicine and Health Sciences Commons^™

An Otopathological Assessment Of Dogs Exposed To Excessive Dietary Fluoride And/Or Suspected Water Borne Toxins, Barbara Ann Hannah

Masters Theses

In 1970, a once very productive Allegan, Michigan dog kennel began experiencing a rash o£ unexplained perinatal deaths and reproductive anomalies in Shetland pups. Anomalies including cleft palate and lip, kinked tails, twisted feet and convulsions immediately before death plagued the neonates. The adult dogs were reported to have tooth mottling, exostoses and auditory and vestibular problems.

Because the dogs had been on high fluoride diets and because the kennel well water was suspected of harboring toxins, a group of 20 Shetland dogs was used to try to find if there was any correlation between the reproductive problems and the …

The Effects Of Xanthine And Adenosine Analogs On Rat Pup Diaphragmatic Contractility, Liam C. Farrell

Masters Theses

Methylxanthines are commonly used in the treatment of respiratory disorders such as asthma, apnea of prematurity and Cheyne-Stokes respiration. Recently, certain methylxanthines have been found to potentiate the contraction of the diaphragm and increase contraction strength of the fatigued diaphragm. The mechanism of action of the methylxanthines is unknown. Three theories have been proposed but each has its supportive and negative points. One theory is that methylxanthines inhibit cyclic AMP phosphodiesterase (PDE) which facilitates contraction by increasing cyclic AMP levels in the cell. Another theory is that methylxanthines antagonize adenosine, thus blocking the adenosine-induced inhibition of contraction. The third theory …