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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
The Relationship Between Pro-Inflammatory Cytokines, Prostaglandins, And Fetal Hypothalamic-Pituitary-Adrenal Axis Activation In Mares With Infective Pre-Term Delivery, Sara K. Lyle
LSU Doctoral Dissertations
Ascending placentitis is a significant cause of abortions, stillbirths, and perinatal loss in horses. A technique for laparoscopic-guided catheterization of the allantoic space was developed and utilized in an experimental model of streptococcal infective pre-term delivery in pony mares. Mares received either 1 x 107 CFU live S. zooepidemicus (n=3), 5.1 x 108 CFU live S. zooepidemicus (n=1), 1 x 107 heat-killed S. zooepidemicus (n=3), 1 mL sterile PBS (n=3). Sham control mares did not receive a transcervical inoculation (n=3). One mare not instrumented with an allantoic catheter received 5.1 x 108 CFU live S. zooepidemicus. Mares with spontaneous abortion …
Characterization And Comparison Of Cell Frequency, Growth, And Multipotential Differentiation Of Adult Mesenchymal Stromal Cells Derived From Equine Bone Marrow And Adipose Tissue, Martin Andreas Vidal
Characterization And Comparison Of Cell Frequency, Growth, And Multipotential Differentiation Of Adult Mesenchymal Stromal Cells Derived From Equine Bone Marrow And Adipose Tissue, Martin Andreas Vidal
LSU Doctoral Dissertations
Equine bone marrow-derived mesenchymal stromal cells (MSCs) and adipose tissue-derived stromal cells (ASCs) were compared for frequency within their respective tissues, cell doubling characteristics and differentiation multipotential in culture based on histochemical staining and compositional analysis. Equine MSCs and ASCs from young adult horses were harvested and isolated from sternal bone marrow and supragluteal subcutaneous adipose tissue, respectively, and grown up to passage 10 (P10) to determine cell doubling characteristics. Limit dilution assays were performed on primary and passaged (P2, P4) MSCs and ASCs to determine the frequency of colony forming units with a fibroblastic phenotype (CFU-F), and the frequency …
The Zinc Induction Of Heme Oxygenase-1 Gene Promoter In Mouse Hepa Cells, Salim M. Alawneh
The Zinc Induction Of Heme Oxygenase-1 Gene Promoter In Mouse Hepa Cells, Salim M. Alawneh
LSU Doctoral Dissertations
Heme oxygenase-1 (HO-1) catalyzes the initial and rate-limiting reaction in heme catabolism (yielding equimolar quantities of iron, carbon monoxide, and biliverdin), which is further metabolized to bilirubin by biliverdin reductase. HO-1, an important enzyme with antioxidant and cytoprotective properties, functions against oxidative stress generated in response to heme and to various stress stimuli, such as zinc. The cytoprotective function of HO-1 is dependent on both the activities of the reaction products and on the inducibility of the heme oxygenase gene (hmox-1), which is regulated primarily at the level of gene transcription by two distal enhancers, E1 and E2. Characterization of …
Novel Oncolytic Herpesviruses For Breast Cancer Treatment, Anna Israyelyan
Novel Oncolytic Herpesviruses For Breast Cancer Treatment, Anna Israyelyan
LSU Doctoral Dissertations
Oncolytic herpes simplex virus type-1 (HSV-1) has shown great potential as an effective agent for cancer therapy ¨C oncolytic virotherapy. To enhance oncolytic capabilities of previously reported agents, new oncolytic and fusogenic HSV-1 OncSyn and OncdSyn viruses were constructed based on wild type HSV-1 (F) strain. To provide for safety and tumor selectivity, the viruses carried a large deletion including one of the two ¦Ã134.5 genes. The ¦Ã134.5 gene, a major neurovirulence factor, was replaced by a gene cassette constitutively expressing the red fluorescent protein. Homologous recombination was utilized to transfer the fusogenic gBsyn3 mutation to the viral genome to …
Phylogenetics And New Approaches To Vaccine Development For West Nile, Arun Venkatesh Iyer
Phylogenetics And New Approaches To Vaccine Development For West Nile, Arun Venkatesh Iyer
LSU Doctoral Dissertations
West Nile virus (WNV) was first isolated in 1937 from a febrile Ugandan woman. WNV now has a worldwide distribution from Australia and India in the east to Europe and the United States in the west. The first human cases of WNV in the United States were detected in New York in 1999. The North American isolates were also found to be highly neuroinvasive and neurovirulent and in many cases leading to mortality or permanent CNS sequelae among humans. WNV was first isolated in Louisiana in 2001. The genome of this virus named LSU-AR01was sequenced and a detailed genetic analysis …