Medicine and Health Sciences Commons^™

The Prevalence Of Sicca Symptoms And Secondary Sjogren In Patients With Rheumatoid Arthritis And It’S Association To Disease Activity, Mostafa A. Doma, Amin A. Abdel-Hady, Abdelhafeez M. Moshri, Ghada M. Mousa

Al-Azhar International Medical Journal

Background: Sjogren disorder (SS) is a persistent foundational immune system sickness of obscure etiology that can happen alone prevalently Sjogren or in relationship with a fundamental connective tissue illness, most regularly rheumatoid joint pain (RA) or lupus erythematosus. Aim: To determine commonness of dryness side effects and optional Sjogren's disorder in patients with rheumatoid joint pain and their relationship with illness movement. Patients and Methods: This cross-sectional review was directed on 100 patients with rheumatoid joint pain chose from the people who went to the short term branch of the Division of Restoration and Rheumatology of Al-Azhar College Clinic in …

Clinical Patterns Of Covid19 In Different Types Of Ckd Patients, Mohamed Elshahat Mahmoud Mousa, Ahmed Alaa Eldin Ahmed, Alsayed Mohamed Rashed, Mohammad Abo-Ghabsha

Al-Azhar International Medical Journal

Background - Nephrologists have been at the forefront of clinical care of patients with COVID-19 as kidney-related complications, including chronic kidney disease (CKD), glomerular disease, and severe electrolyte derangements, are frequently encountered.

Aim - to estimate the effect of Covid-19 viral infection on chronic kidney disease patients and to determine clinical characteristics of disease.

Patients and Methods - A retrospective case study for 50 patients with Chronic Kidney Disease from stage 1 to stage 5 presented with covid 19 infection which confirmed by PCR to El Sheikh Zyed Al Nahyan hospital from 1st of August 2021 to 1st of January …

Clinical Significance Of Urinary Tumor Necrosis Factor-Like Weak Inducer Of Apoptosis In Lupus Nephritis, Elsayed Mohamed Rashed, Hani Ismail Hamed, Abdelsalam Fathy Abdelsalam, Amr Atef Ali Aref

Al-Azhar International Medical Journal

Background: TWEAK is a cytokine that is both pleiotropic and multifunctional. It is a member of the tumor necrosis factor (TNF) superfamily, which regulates the pathways that lead to inflammation. TWEAK is a critical component in the development of lupus nephritis (LN) because it is responsible for the death of renal mesangial cells and tubular epithelial cells. This death occurs as a result of several intracellular signal transduction cascades. Aim and Objectives: to better understand how Tweak is related to lupus nephritis, and to look at whether or not Tweak levels may be used as a marker of LN existence …

Cardiac Function During Weaning Failure: The Role Of Systolic & Diastolic Dysfunction, Amr Adel Elfar, Atef Abo-Elfetouh Ibrahim, Ahmed Mohammed Abo-Hassan, Taiseer Ahmed Shawky, Wael Mohammed Atia, Mahmoud Abd-Allatif Hashish

Al-Azhar International Medical Journal

Background: Patients are at risk for grave outcomes due to weaning failure and early reintubation. The most prevalent reason why an attempt to wean fails is cardiac dysfunction. Aim of study: The key objectives of this prospective research is: To examine the connection between heart function and weaning outcomes at the beginning of the procedure and befor extubation. Patients and Methods: The study included finally 100 subject collected in critical care unit at internal medicine department in Al-Hussein university hospital from July 2019 until July 2021.Echocardiography performed ,systolic & diastolic functions were measured at base line ventilator setting and before …

Evaluation Of Serum Proprotein Convertase Subtilisin Kexin Type 9 (Pcsk9) As A Diagnostic Biomarker Of Hepatic Steatosis, Alaa M. E. Antar, Karima Youssef Ahmed, Fatma El Zahraa Ae Diab, Fatma M. Kotb

Al-Azhar International Medical Journal

Background: Triglyceride intake or synthesis increases and/or triglyceride outflow decreases in the liver, respectively, to cause hepatic steatosis. Aim of the Work: To evaluate serum levels of proprotein convertase subtilisin kexin type 9 (pcsk9) as a diagnostic biomarker of hepatic steatosis and their correlations with the severity of the disease. Subject and Methods: This case-control research was conducted in the Department of Internal Medicine, Al-Zahraa University Hospital, and included sixty Egyptian patients with hepatic steatosis (group I) diagnosed by pelvic-abdominal ultrasound with (group Ib includes 30 cases) or without (group Ia includes 30 cases) diabetes mellitus, as well as thirty …

The Role Of Insulin Resistance In The Prediction Of Esophageal Varices In Cirrhotic Non-Diabetic Patients, Abdelhaleim Abdelghany Hasabo, Mahmoud Osama Ahmed Abd El Fatah, Mohamed Basiouny Yahia, Gamal Zakaria Ali Morsy

Al-Azhar International Medical Journal

Background: Esophageal Varices (EV) caused by liver cirrhosis is a very common complication where endoscopy is the best screening procedure. Insulin resistance (IR) is a reliable predictor of portal hypertension. Aim of the work: This study aims to compare and evaluate the role of markers of insulin resistance and other non-invasive markers in detection of EVs in patients with liver cirrhosis. Patients and Methods: fifty patients were screened in this cross-sectional study in the gastroenterology unit of internal medicine department by abdominal ultrasound. ELISA technique was used to estimate fating serum insulin levels. Furthermore, (HOMA-IR) referring to the Homeostasis model …

Role Of Endosialin/Cd248 And Cytoglobin In Liver Fibrosis, Mahmoud Abdallah Mansour, Khaled Abd Elazeme Eid, Ashraf Mohamed Elkabeer, Eglal Mohamed Kenawy, Bakheet Elkot Mostafa Elsadek

Al-Azhar International Medical Journal

Background - Chronic liver diseases are a major global health burden. CYGB, Human IV globin is abundantly expressed in Hepatic Stellate Cell(HSCs) between hepatocytes. CYGB can bind oxygen and nitric oxide and is said to protect HSCs from reactive oxygen species(ROS).

Aim - to estimate role of CD248 and Cygb in process of liver fibrosis.

Patients and Methods - This study was conducted on forty-four Egyptian patients with hepatic stenosis detected by ultrasound, and forty healthy volunteers as control group.

Results - Our results showed statistical significant (p-value < 0.001) increased CD248 in patients group (189.03 ± 66.6) when compared with control group (138.7 ± 36.5), decreased Cygb in patients group (1.62 ± 0.35) when compared with control group (1.93 ± 0.26)

Conclusion - Our study identified Cygb and CD248 …

Study Of Helicobacter Pylori Infection In Chronic Hepatitis (C) Infection Among Egyptian Patients, Rabei Fathy Abbas, Ahmed Abdul Hameid Abo Zied, Ragab El-Saed El-Dibany

Al-Azhar International Medical Journal

Objectives: Our objective is to assess H. pylori infection in chronic hepatitis C Egyptian patients and its hepatic impact.

Background: Helicobacter pylori lives mainly on gastric mucosa and is one of the common infections worldwide.

In liver cirrhosis it may lead to impaired liver functions due to fibrosis in chronic liver diseases as HCV.

Patients and Methods: This was a cross sectional prospective study included 40 of HCV infection and 20 health subjects as a control. It was conducted on in the Al-Azhar University Hospitals during the period from 1st Feb 2020 to 30th Sept 2021.

After approval of local …

Hemoglobin Changes As A Marker Of Blood Volume Changes In Hemodialysis Patients, Safwat Farrag Ahmed, Hani Ismail Hamed, Mohamed Elsayed Abu Ghabsha, Mostafa Abd El Hady Ibrahim Gabr

Al-Azhar International Medical Journal

Background: Hemodialysis patients routinely employ relative blood volume (RBV) monitoring to direct fluid management and enhance cardiovascular stability, Aim: In order to determine how estimates of relative blood volume changes may vary based on the monitoring method, the current study sought to examine changes in hematocrit, haemoglobin, or total blood protein concentration in patients receiving normal maintenance hemodialysis. Subject and Methods: This was a prospective cross-sectional study curried out at Nephrology Departments of Al Hussien University Hospitals and Ahmed Maher Teaching Hospital. The study was conducted over a one-year period, from September 2021 till September 2022. Results: globulin level showed …

Comparative Study Between Glycated Hemoglobin And Glycated Albumin In Diabetes In Hemodialysis Patients, Alsayed Mohamed Rashed, Reda Fakhry Mohamed, Mohamed Alsayed Abo Ghabsha, Mohamed Shehata Shaaban Ghoneim

Al-Azhar International Medical Journal

Background: The importance of accurately measuring glycemic control in the diabetic people cannot be overstated, since better glycemic control decreases micro- and macrovascular problems in individuals with diabetes mellitus getting renal replacement treatment. Aim: This study's objective was to contrast between glycated hemoglobin and glycated albumin in diabetes in hemodialysis patients. Subject and Methods: This was Prospective Comparative research caried out on 100 diabetic patients. Two groups were created out of them: Group (I): that had 50 patients’ diabetic on hemodialysis. Group (II): that included 50 patients diabetic not on hemodialysis. From March 2022 to September 2022, this research was …

Evaluation Of Thyroid Hormones Level In Chronic Kidney Disease Patients, Mustafa Mahmoud Mohamed Alsagheer, Ayman Abdel.Azeez Abdel. Rahman, Mona Mohamed Abdelmeguid, Abdelhamed Abdelrazik Abdelhafez

Al-Azhar International Medical Journal

Background - Chronic-kidney disease is a global issue worldwide. The hypothalamus-pituitary-thyroid axis, peripheral-circulation, and production of thyroid-hormone release/or excretion are all affected by the etiology of thyroid dysfunction in CKD patients.

Aim - to measure the levels of TSH, T3, T4, in CKD patients.

Patients and Methods - The control group in this study, which included sixty CKD patients from Egypt, consisted of thirty healthy volunteers (subjects without CKD). There were three groups of participants: Group (1) 30 patients with CKD in Group (2) 30 CKD patients on dialysis regularly; Group 3: 30 healthy people without CKD.

Results - There …

Prevalence Of Iron Overload Cardiomyopathy (Ioc) In Transfuion-Dependant Anaemic Patients, Ramadan Gamal Riyad Abbas, Youssef Khalil Eissa, Yasser El-Sayed Mohamed, Youssef Abd Allah Nassar

Al-Azhar International Medical Journal

Introduction: The accumulation of iron in the myocardium causes iron overload cardiomyopathy (IOC), which is the primary cause of fatalities in individuals receiving long blood transfusion treatment.

Aim of the work: The study's goal is to determine the prevalence of IOC in patients with blood transfusion-dependent chronic anemia.

Patients& methods The current prospective study included 50 patient with chronic anemia with history of repeated blood transfusion , attending to hematology unit , internal medicine department of faculty of medicine, Al-Azhar university in Cairo, those patients had more than 2 years diagnosis of anemia, repeated blood transfusion in last 2 years …

Ascaris Lumbricoides Impact On Hosue Dust Mite Sensitization And Bronchial Asthma Severity, Shady Muhamed Hassan, Gamal Ali Abo Sheishea, Abdel Wahab Mohamed Lotfy, Hafez Ahmed Abd El-Hafez, Khairy Abd El-Hamid Hassan

Al-Azhar International Medical Journal

Background: It is possible that environmental allergens and intestinal parasites share antigens that can modulate allergic immune responses. Cross-reactivity studies between common parasitic helminths and house dust mites impacting people is gaining popularity, especially in underdeveloped countries.

Aim of the study: The objective of this study is to study the relation between Ascaris lumbricoids infection with or without treatment on mite sensitization as well as the pathogenic relation between Ascaris and bronchial asthma; if any, and consequent clinical implication on asthma severity.

Subjects and methods: This study comprised of 80 atopic asthmatic patients of moderate severity according to the Global …

Impact Of Diabetes Mellitus In Arteriovenous Fistula Dysfunction In Patients On Regular Hemodialysis, Emad Allam Mohamed, Mohamed Ahmed Elsayed, Mohamed Abo Elnaga Mohamed, Mohamed Amer Farok Amin

Al-Azhar International Medical Journal

Background: Primary arteriovenous fistula (AVF) failure has been linked to the existence of diabetes mellitus in some individuals, but not in all. Aim of the work: The study's objective is to assess how Diabetes Mellitus affects individuals receiving regular hemodialysis (HD) who have AVF malfunction. Patient and methods: All of the 90 participants in this research had end-stage renal disease (ESRD) and were being treated with regular HD. The subjects were separated into three groups according on age and sex; Group A had Twenty (20) non-diabetic patients enrolled as control group without any diagnosis of liver disease, Group B had …

Study Of Il -17 As An Add-On Biomarker For Evaluation Of Lupus Nephritis Activity, Abdel Wahab Mohammed Lotfy, Ibrahim Mohamed Rageh, Farag Khalil, Mahmoud Mostafa Kamel

Al-Azhar International Medical Journal

Background: The Th17/IL-17 axis is characterized primarily by its effector and proinflammatory properties. Present serologic and urine indicators are not linked well with nephritic activity in systemic lupus erythematosus (SLE), despite the great efficacy of biomarkers for the diagnosis of SLE. Aim and objectives: we plan to study the role of adding IL-17 to C3 and C4 as a complementary indicator of lupus nephritis(LN) activity. Subjects and methods: This cross sectional observisional research, includes 60 patients selected from attendee of immunology and allergy center, AL-Azhar University. Results: there was a statistically significant variance amongst our research populations regarding contrast amongst …

Sickle Cell Patients With Dengue Infection Waiting For Down: Case Report, Ali Madian

Al-Azhar International Medical Journal

We report a case of Dengue infection in a 20- year- old male with sickle cell anemia who presents to the emergency department with fever, retro orbital headache, bone pain, back pain and myalgia. Laboratory tests revealed elevated hematocrit, thrombocytopenia, IgM and IgG antibodies positivity to dengue virus. The patient was treated with intravenous fluid hydration and paracetamol with rapid deterioration and development of acute respiratory distress and hypovolemic shock due to alveolar hemorrhage.

Urinary Monocyte Chemoattractant Protein-1 As A Diagnostic Marker Of Lupus Nephritis, Hendawy Abdel-Moety Zedan, Mohmmed Hassan Attia, Ahmed Ali Assem, Saad Gamal Saad Alabgoly

Al-Azhar International Medical Journal

Background: Systemic lupus erythematosus, sometimes known as SLE, is an autoimmune illness can have far-reaching effects on bodily functions. Renal impairment is among SLE's most devastating effects. It affects forty to seventy percent of patients. One of the most important chemokines in attracting monocytes and macrophages to areas of inflammation is monocyte chemoattractant protein-1 (MCP1). Aim and objectives: to determine if MCP-1 can aid in the early detection of lupus nephritis as well as look at any possible links among MCP-1 levels & disease severity in addition kidney function. Subjects and methods: 60 patients with age ranging between 20-60 years …

Correlations Between Intradialytic Hypoxemia And Complications In Patients Undergoing Regular Hemodialysis, Shaimaa Atef Mokhtar, Lamiaa Ismail Ahmed, Sarah Mahmoud El Hadad

Al-Azhar International Medical Journal

Background: Dialysis is a replacement of renal functioning in patients with end stage renal disease (ESRD). Approximately 10% of chronic regular hemodialysis patients have arterial oxygen saturation less than 90% for more than one-third of their dialysis session, which was associated with increased rates of hospitalization and also mortality.

Aim of the work: This current study is aimed to assess of effect of intradialytic hypoxemia as a complication may occurs during hemodialysis session and its impact on clinical and laboratory parameters of patients with ESRD undergoing regular hemodialysis.

Patients and methods: the current work is a hospital based Cross sectional …

Role Of Urinary Podocalyxin In Early Diagnosis Of Diabetic Kidney Disease, Mostafa Abdel Fattah El-Ballat, Mohamed Hasan Attia, Ahmed Ali Ali Assem, Abd Ellatif Ibrahim Abd Ellatif

Al-Azhar International Medical Journal

Background: Major complications of diabetes include diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD). When DN is diagnosed and treated early on, its progression to ESRD can be slowed. It is recommended to start screening for DN at the time of diagnosis because approximately three percent of newly diagnosed cases of T2DM already have overt nephropathy. Aim and objectives: to test podocalyxin in the urine for its potential as a non-invasive diagnostic for early diagnosis of diabetic kidney damage. Subjects and methods: Eighty patients were analyzed in this cross-sectional study that took place over the course of …