Medicine and Health Sciences Commons^™

Increased Number Of Circulating Exosomes And Their Microrna Cargos Are Potential Novel Biomarkers In Alcoholic Hepatitis, Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Gyongyi Szabo

Gyongyi Szabo

BACKGROUND: It has been well documented that alcohol and its metabolites induce injury and inflammation in the liver. However, there is no potential biomarker to monitor the extent of liver injury in alcoholic hepatitis patients. MicroRNAs (miRNAs) are a class of non-coding RNAs that are involved in various physiologic and pathologic processes. In the circulation, a great proportion of miRNAs is associated with extracellular vesicles (EVs)/exosomes. Here, we hypothesized that the exosome-associated miRNAs can be used as potential biomarkers in alcoholic hepatitis (AH).

METHODS: Exosomes were isolated from sera of alcohol-fed mice or pair-fed mice, and plasma of alcoholic hepatitis …

Research Brief: "Alcohol Use And Craving Among Veterans With Mental Health Disorders And Mild Traumatic Brain Injury", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the relation between alcohol craving and mental health disorders among veterans, and how mental health disorders impact alcohol cravings. For policy and practices, the research shows that alcohol cravings and mental health disorders among veterans could be a sign for risk of alcohol use disorder. It also shows that the VA should assess veterans for alcohol use disorder, and also research more ties between mental health disorders and alcohol use. Suggestions for future research include conducting the study in a larger, more representative population, as well as involving families in measuring alcohol use/cravings to ensure less …

Screening And Brief Intervention For Alcohol Misuse In Older Adults: Training Outcomes Among Physicians And Other Healthcare Practitioners In Community-Based Settings, Constance L. Coogle, Myra G. Owens

Forensic Science Publications

Screening and brief intervention (SBI) is increasingly available to older adults who engage in at-risk drinking. This study examined the extent to which SBI training influenced the willingness of healthcare providers in a community-based hospital and other clinical settings to promote the implementation of SBI. Ninety-three healthcare practitioners (primarily physicians, nurses, and social workers) who attended SBI training were asked about their intentions to apply the information in their professional practice, as well as their enthusiasm about recommending the training to others in their profession. Although there were no differences among the professions in terms of commitment to apply the …