Medicine and Health Sciences | Open Access Articles

Biosecurity And The Role Of Statisticians, Ron Brookmeyer

Ron Brookmeyer

No abstract provided.

The Importance Of Experimental Design In Proteomic Mass Spectrometry Experiments: Some Cautionary Tales, Jeffrey S. Morris, Jianhua Hu, Kevin R. Coombes, Keith A. Baggerly

Jeffrey S. Morris

Proteomic expression patterns derived from mass spectrometry have been put forward as potential biomarkers for the early diagnosis of cancer and other diseases. This approach has generated much excitement and has led to a large number of new experiments and vast amounts of new data. The data, derived at great expense, can have very little value if careful attention is not paid to the experimental design and analysis. Using examples from surfaceenhanced laser desorption/ionisation time-of-flight (SELDI-TOF) and matrix-assisted laser desorption–ionisation/time-of-flight (MALDI-TOF) experiments, we describe several experimental design issues that can corrupt a dataset. Fortunately, the problems we identify can be …

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The $\Alpha$ And The $\Omega$ Of Congeneric Test Theory: An Extension Of Reliability And Internal Consistency To Heterogeneous Tests, Joseph F. Lucke

Joseph Lucke

Psychometric theory focuses primarily on tests that are homogeneous, that measure only one attribute of a psychosocial entity. However, the complexity of psychosocial behavior often requires tests that are heterogeneous, that measure more than one attribute. In this presentation, reliability and internal consistency are extended to heterogeneous tests under the rubric of congeneric test theory. The extensions show that reliability and internal consistency have very similar properties. Reliability and internal consistency are shown to be unique up to a linear transformation. Whereas internal consistency is a lower bound to reliability in the homogeneous case, it is a strict lower bound …