Medicine and Health Sciences Commons^™

Bioactive Growth Hormone In Older Men And Women: Its Relationship To Immune Markers And Healthspan, William J. Kraemer, Mary J. Kennett, Andrea M. Mastro, Roger J. Mccarter, Connie J. Rogers, William H. Dupont, Shawn D. Flanagan, William J. Turbitt, Maren S. Fragala, Emily M. Post, Wesley C. Hymer

Health and Sport Sciences Faculty Scholarship

Objective: The consequences of age-related decline in the somatotropic axis of humans are complex and remain largely unresolved. We tested the hypothesis that hGH measurements of plasma by bioassay vs immunoassay from samples obtained from free-living, elderly individuals would reveal a dichotomy in GH activities that are correlated with the functional status of the donors, i.e. their healthspan.

Design: Forty-one men and women of advanced age (men: N=16, age, 80.5±6.5years; height, 173.1±6.9cm; body mass, 81.8±13.0kg) and (women: N=25, age, 80.7±7.2years; height, 157.7±6.0cm; body mass, 68.8±17kg), were recruited for a cross-sectional study. Participants filled out PROMIS (Patient-Reported Outcomes Measurement Information System, …