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Full-Text Articles in Medicine and Health Sciences
Effects Of Endurance Training On Skeletal Muscle Mass And Inflammation In A Rat Model Of Heart Failure, Aaron Garcia, Dillon Harris, Quinten Pigg, Daniela Sayuri Inoue, Mariana Janini Gomes
Effects Of Endurance Training On Skeletal Muscle Mass And Inflammation In A Rat Model Of Heart Failure, Aaron Garcia, Dillon Harris, Quinten Pigg, Daniela Sayuri Inoue, Mariana Janini Gomes
International Journal of Exercise Science: Conference Proceedings
Chronic disease states including heart failure (HF) often lead to reduced physical activity, resulting in disuse and low-level systemic inflammation, which contribute to the decline in muscle mass and function. An important goal of therapy in HF patients is to counteract or prevent the development of skeletal muscle alterations in order to restore a normal functional capacity. Exercise is an established means of improving exercise capacity and quality of life in patients with HF. Therefore, we aimed to evaluate the impact of an endurance program on skeletal muscle mass and inflammation in a rat model of pulmonary arterial hypertension (PAH)-induced …
Systemic Inflammation Persists In Rats With Heart Failure After A Short-Term Endurance Training Protocol, Quinten Pigg, Dillon Harris, Aaron Garcia, Daniela Sayuri Inoue, Mariana Janini Gomes
Systemic Inflammation Persists In Rats With Heart Failure After A Short-Term Endurance Training Protocol, Quinten Pigg, Dillon Harris, Aaron Garcia, Daniela Sayuri Inoue, Mariana Janini Gomes
International Journal of Exercise Science: Conference Proceedings
Exercise has been shown to produce an anti-inflammatory response and an increased exercise tolerance in heart failure (HF) patients. In rats, monocrotaline (MCT) leads to pulmonary arterial hypertension-induced HF (PAH-HF), resulting in exercise intolerance and chronic inflammation. However, little is known about the effects of endurance training in rats with PAH-HF induced by monocrotaline. PURPOSE: To investigate the effects of an endurance training protocol on systemic inflammatory markers and exercise tolerance in rats with HF. METHODS: 30 male Wistar rats (~250g) were randomly divided into 4 groups: control untrained (CU); control trained (CT), PAH-HF untrained (HFU), and PAH-HF trained (HFT). …